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Protective Effects of Commiphora erythraea Resin Constituents Against Cellular Oxidative Damage
Dipartimento di Chimica e Tecnologia del Farmaco, University of Perugia, via del Liceo, 1-06123 Perugia, Italy
Dipartimento di Scienze della Terra, della Vita e dell’Ambiente (DiSTeVA), University of Urbino “Carlo Bo”, via Bramante, 28-061029 Urbino, Italy
Dipartimento di Medicina Sperimentale e Scienze Biochimiche, University of Perugia, via del Giochetto-06124 Perugia, Italy
* Author to whom correspondence should be addressed.
Received: 10 November 2011; in revised form: 5 December 2011 / Accepted: 7 December 2011 / Published: 14 December 2011
Abstract: By bioguided fractionation of the hexane extract of Commiphora erythraea resin we isolated four furanosesquiterpenoids that were tested for their protective activity against oxidative stress. Furanodienone and 1,10(15)-furanogermacra-dien-6-ones showed to be potent inhibitors of lipid peroxidation (IC50 of ~0.087 μM), being more active than the methoxylated analogues. Furthermore, using BV2 microglial cells, we found that furanodienone from C. erythraea is able to counteract LPS-induced cell death and decrease LPS-induced NO generation thus protecting microglial cells from LPS-induced cytotoxicity. Finally, docking studies were undertaken to gain insight into the possible binding mode of the isolated compounds at 5-LOX binding site.
Keywords: Commiphora erythraea (Burseraceae); furanodienone; lipid peroxidation; 5-LOX; antioxidant
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Marcotullio, M.C.; Messina, F.; Curini, M.; Macchiarulo, A.; Cellanetti, M.; Ricci, D.; Giamperi, L.; Bucchini, A.; Minelli, A.; Mierla, A.L.; Bellezza, I. Protective Effects of Commiphora erythraea Resin Constituents Against Cellular Oxidative Damage. Molecules 2011, 16, 10357-10369.
Marcotullio MC, Messina F, Curini M, Macchiarulo A, Cellanetti M, Ricci D, Giamperi L, Bucchini A, Minelli A, Mierla AL, Bellezza I. Protective Effects of Commiphora erythraea Resin Constituents Against Cellular Oxidative Damage. Molecules. 2011; 16(12):10357-10369.
Marcotullio, Maria Carla; Messina, Federica; Curini, Massimo; Macchiarulo, Antonio; Cellanetti, Marco; Ricci, Donata; Giamperi, Laura; Bucchini, Anahi; Minelli, Alba; Mierla, Anna Lisa; Bellezza, Ilaria. 2011. "Protective Effects of Commiphora erythraea Resin Constituents Against Cellular Oxidative Damage." Molecules 16, no. 12: 10357-10369.