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• Marcotullio, M
• Messina, F
• Curini, M
• Macchiarulo, A
• Cellanetti, M
• Ricci, D
• Giamperi, L
• Bucchini, A
• Minelli, A
• Mierla, A
• Bellezza, I
• [+] on Google Scholar
• Marcotullio, M
• Messina, F
• Curini, M
• Macchiarulo, A
• Cellanetti, M
• Ricci, D
• Giamperi, L
• Bucchini, A
• Minelli, A
• Mierla, A
• Bellezza, I
• [+] on PubMed
• Marcotullio, M
• Messina, F
• Curini, M
• Macchiarulo, A
• Cellanetti, M
• Ricci, D
• Giamperi, L
• Bucchini, A
• Minelli, A
• Mierla, A
• Bellezza, I

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Molecules 2011, 16(12), 10357-10369; doi:10.3390/molecules161210357

Article

Protective Effects of Commiphora erythraea Resin Constituents Against Cellular Oxidative Damage

Maria Carla Marcotullio ^1,* , Federica Messina ¹ , Massimo Curini ¹ , Antonio Macchiarulo ¹ , Marco Cellanetti ¹ , Donata Ricci ² , Laura Giamperi ² , Anahi Bucchini ² , Alba Minelli ³ , Anna Lisa Mierla ³  and Ilaria Bellezza ³

¹ Dipartimento di Chimica e Tecnologia del Farmaco, University of Perugia, via del Liceo, 1-06123 Perugia, Italy ² Dipartimento di Scienze della Terra, della Vita e dell’Ambiente (DiSTeVA), University of Urbino “Carlo Bo”, via Bramante, 28-061029 Urbino, Italy ³ Dipartimento di Medicina Sperimentale e Scienze Biochimiche, University of Perugia, via del Giochetto-06124 Perugia, Italy

* Author to whom correspondence should be addressed.

Received: 10 November 2011; in revised form: 5 December 2011 / Accepted: 7 December 2011 / Published: 14 December 2011

(This article belongs to the Section Natural Products)

Download PDF Full-Text [293 KB, uploaded 14 December 2011 09:24 CET]

Abstract: By bioguided fractionation of the hexane extract of Commiphora erythraea resin we isolated four furanosesquiterpenoids that were tested for their protective activity against oxidative stress. Furanodienone and 1,10(15)-furanogermacra-dien-6-ones showed to be potent inhibitors of lipid peroxidation (IC₅₀ of ~0.087 μM), being more active than the methoxylated analogues. Furthermore, using BV2 microglial cells, we found that furanodienone from C. erythraea is able to counteract LPS-induced cell death and decrease LPS-induced NO generation thus protecting microglial cells from LPS-induced cytotoxicity. Finally, docking studies were undertaken to gain insight into the possible binding mode of the isolated compounds at 5-LOX binding site.

Keywords: Commiphora erythraea (Burseraceae); furanodienone; lipid peroxidation; 5-LOX; antioxidant

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