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Molecules 2011, 16(12), 10357-10369; doi:10.3390/molecules161210357

Protective Effects of Commiphora erythraea Resin Constituents Against Cellular Oxidative Damage

1
Dipartimento di Chimica e Tecnologia del Farmaco, University of Perugia, via del Liceo, 1-06123 Perugia, Italy
2
Dipartimento di Scienze della Terra, della Vita e dell’Ambiente (DiSTeVA), University of Urbino “Carlo Bo”, via Bramante, 28-061029 Urbino, Italy
3
Dipartimento di Medicina Sperimentale e Scienze Biochimiche, University of Perugia, via del Giochetto-06124 Perugia, Italy
*
Author to whom correspondence should be addressed.
Received: 10 November 2011 / Revised: 5 December 2011 / Accepted: 7 December 2011 / Published: 14 December 2011
(This article belongs to the Section Natural Products)
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Abstract

By bioguided fractionation of the hexane extract of Commiphora erythraea resin we isolated four furanosesquiterpenoids that were tested for their protective activity against oxidative stress. Furanodienone and 1,10(15)-furanogermacra-dien-6-ones showed to be potent inhibitors of lipid peroxidation (IC50 of ~0.087 μM), being more active than the methoxylated analogues. Furthermore, using BV2 microglial cells, we found that furanodienone from C. erythraea is able to counteract LPS-induced cell death and decrease LPS-induced NO generation thus protecting microglial cells from LPS-induced cytotoxicity. Finally, docking studies were undertaken to gain insight into the possible binding mode of the isolated compounds at 5-LOX binding site.
Keywords: Commiphora erythraea (Burseraceae); furanodienone; lipid peroxidation; 5-LOX; antioxidant Commiphora erythraea (Burseraceae); furanodienone; lipid peroxidation; 5-LOX; antioxidant
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Marcotullio, M.C.; Messina, F.; Curini, M.; Macchiarulo, A.; Cellanetti, M.; Ricci, D.; Giamperi, L.; Bucchini, A.; Minelli, A.; Mierla, A.L.; Bellezza, I. Protective Effects of Commiphora erythraea Resin Constituents Against Cellular Oxidative Damage. Molecules 2011, 16, 10357-10369.

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