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Molecules 2011, 16(12), 10357-10369; doi:10.3390/molecules161210357
Article

Protective Effects of Commiphora erythraea Resin Constituents Against Cellular Oxidative Damage

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1 Dipartimento di Chimica e Tecnologia del Farmaco, University of Perugia, via del Liceo, 1-06123 Perugia, Italy 2 Dipartimento di Scienze della Terra, della Vita e dell’Ambiente (DiSTeVA), University of Urbino “Carlo Bo”, via Bramante, 28-061029 Urbino, Italy 3 Dipartimento di Medicina Sperimentale e Scienze Biochimiche, University of Perugia, via del Giochetto-06124 Perugia, Italy
* Author to whom correspondence should be addressed.
Received: 10 November 2011 / Revised: 5 December 2011 / Accepted: 7 December 2011 / Published: 14 December 2011
(This article belongs to the Section Metabolites)
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Abstract

By bioguided fractionation of the hexane extract of Commiphora erythraea resin we isolated four furanosesquiterpenoids that were tested for their protective activity against oxidative stress. Furanodienone and 1,10(15)-furanogermacra-dien-6-ones showed to be potent inhibitors of lipid peroxidation (IC50 of ~0.087 μM), being more active than the methoxylated analogues. Furthermore, using BV2 microglial cells, we found that furanodienone from C. erythraea is able to counteract LPS-induced cell death and decrease LPS-induced NO generation thus protecting microglial cells from LPS-induced cytotoxicity. Finally, docking studies were undertaken to gain insight into the possible binding mode of the isolated compounds at 5-LOX binding site.
Keywords: Commiphora erythraea (Burseraceae); furanodienone; lipid peroxidation; 5-LOX; antioxidant Commiphora erythraea (Burseraceae); furanodienone; lipid peroxidation; 5-LOX; antioxidant
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Marcotullio, M.C.; Messina, F.; Curini, M.; Macchiarulo, A.; Cellanetti, M.; Ricci, D.; Giamperi, L.; Bucchini, A.; Minelli, A.; Mierla, A.L.; Bellezza, I. Protective Effects of Commiphora erythraea Resin Constituents Against Cellular Oxidative Damage. Molecules 2011, 16, 10357-10369.

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