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Molecules 2011, 16(12), 10337-10346; doi:10.3390/molecules161210337
Article

Synthesis, Characterization, Anti-Inflammatory and in Vitro Antimicrobial Activity of Some Novel Alkyl/Aryl Substituted Tertiary Alcohols

1, 1, 2,*  and 3
1 Department of Chemistry, Quaid-i-azam University, Islamabad 45320, Pakistan 2 Department of Chemistry, Allam Iqbal Open University, Islamabad 44000, Pakistan 3 Riphah Institute of Pharmaceutical Sciences, Islamabad 44000, Pakistan
* Author to whom correspondence should be addressed.
Received: 20 November 2011 / Revised: 5 December 2011 / Accepted: 6 December 2011 / Published: 14 December 2011
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Abstract

The synthesis of some novel alkyl/aryl substituted tertiary alcohols was accomplished in two steps. The synthetic route involves preparation of Grignard reagents by treating alkyl/aryl bromides with magnesium turnings in dry ether. Then substituted chalcones were reacted with the Grignard reagents to afford alkyl/aryl substituted tertiary alcohols 1-10. The structures of the synthesized compounds were assigned on the basis of FT-IR, 1H-NMR, 13C-NMR and mass spectroscopic data. The in vivo anti-inflammatory activity of the synthesized compounds was evaluated using the carrageenan-induced hind paw edema method and was compared with that of ibuprofen. Some of the newly synthesized compounds showed promising anti-inflammatory activity. The tertiary alcohols 1-10 were also screened for antibacterial activity against ten bacterial strains using seven Gram-positive and three Gram-negative bacteria and for antifungal activity against Aspergillus Flavus, Aspergillus Niger and Aspergillus pterus. Tertiary alcohols 1-10 were found to exhibit good to excellent antimicrobial activities compared to levofloxacin and fluconazole used as standard drugs.
Keywords: tertiary alcohols; anti-inflammatory activity; antibacterial activity; antifungal activity tertiary alcohols; anti-inflammatory activity; antibacterial activity; antifungal activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Baseer, M.; Ansari, F.L.; Ashraf, Z.; SaeedulHaq, R. Synthesis, Characterization, Anti-Inflammatory and in Vitro Antimicrobial Activity of Some Novel Alkyl/Aryl Substituted Tertiary Alcohols. Molecules 2011, 16, 10337-10346.

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