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Molecules 2011, 16(12), 10337-10346; doi:10.3390/molecules161210337
Article

Synthesis, Characterization, Anti-Inflammatory and in Vitro Antimicrobial Activity of Some Novel Alkyl/Aryl Substituted Tertiary Alcohols

1, 1, 2,*  and 3
Received: 20 November 2011; in revised form: 5 December 2011 / Accepted: 6 December 2011 / Published: 14 December 2011
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Abstract: The synthesis of some novel alkyl/aryl substituted tertiary alcohols was accomplished in two steps. The synthetic route involves preparation of Grignard reagents by treating alkyl/aryl bromides with magnesium turnings in dry ether. Then substituted chalcones were reacted with the Grignard reagents to afford alkyl/aryl substituted tertiary alcohols 1-10. The structures of the synthesized compounds were assigned on the basis of FT-IR, 1H-NMR, 13C-NMR and mass spectroscopic data. The in vivo anti-inflammatory activity of the synthesized compounds was evaluated using the carrageenan-induced hind paw edema method and was compared with that of ibuprofen. Some of the newly synthesized compounds showed promising anti-inflammatory activity. The tertiary alcohols 1-10 were also screened for antibacterial activity against ten bacterial strains using seven Gram-positive and three Gram-negative bacteria and for antifungal activity against Aspergillus Flavus, Aspergillus Niger and Aspergillus pterus. Tertiary alcohols 1-10 were found to exhibit good to excellent antimicrobial activities compared to levofloxacin and fluconazole used as standard drugs.
Keywords: tertiary alcohols; anti-inflammatory activity; antibacterial activity; antifungal activity tertiary alcohols; anti-inflammatory activity; antibacterial activity; antifungal activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Baseer, M.; Ansari, F.L.; Ashraf, Z.; SaeedulHaq, R. Synthesis, Characterization, Anti-Inflammatory and in Vitro Antimicrobial Activity of Some Novel Alkyl/Aryl Substituted Tertiary Alcohols. Molecules 2011, 16, 10337-10346.

AMA Style

Baseer M, Ansari FL, Ashraf Z, SaeedulHaq R. Synthesis, Characterization, Anti-Inflammatory and in Vitro Antimicrobial Activity of Some Novel Alkyl/Aryl Substituted Tertiary Alcohols. Molecules. 2011; 16(12):10337-10346.

Chicago/Turabian Style

Baseer, Muhammad; Ansari, Farzana Latif; Ashraf, Zaman; SaeedulHaq, Rafiuzzaman. 2011. "Synthesis, Characterization, Anti-Inflammatory and in Vitro Antimicrobial Activity of Some Novel Alkyl/Aryl Substituted Tertiary Alcohols." Molecules 16, no. 12: 10337-10346.


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