Abstract: The immunomodulatory function of longan pulp polysaccharide-protein complex (LP3) was investigated in immunosuppressed mice models. Compared with the model control, peroral administration of 100 mgkg−1d−1 LP3 could significantly increase/enhance antibody production against chicken red blood cell (CRBC), concanavalin A (ConA)-induced splenocyte proliferation, macrophage phagocytosis, NK cell cytotoxicity against YAC-1 lymphoma cell, and interferon-gamma (INF-γ) and interleukin-2 (IL-2) secretion in serum (P < 0.05). The immunomodulatory effects, except for those on splenocytes and macrophages (P > 0.05), were also observed in mice administered with 50 or 200 mgkg−1d−1 LP3 (P < 0.05). The beneficial effects of 50–200 mgkg−1d−1 LP3 were comparable to those of 50 mgkg−1d−1 ganoderan. The strong immunomodulatory activity of LP3 confirmed its good potential as an immunotherapeutic adjuvant.
Keywords: longan pulp; polysaccharide-protein complex; immunomodulatory activity; immunosuppressed mice; cyclophosphamide
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Yi, Y.; Liao, S.-T.; Zhang, M.-W.; Zhang, R.-F.; Deng, Y.-Y.; Yang, B.; Wei, Z.-C. Immunomodulatory Activity of Polysaccharide-Protein Complex of Longan (Dimocarpus longan Lour.) Pulp. Molecules 2011, 16, 10324-10336.
Yi Y, Liao S-T, Zhang M-W, Zhang R-F, Deng Y-Y, Yang B, Wei Z-C. Immunomodulatory Activity of Polysaccharide-Protein Complex of Longan (Dimocarpus longan Lour.) Pulp. Molecules. 2011; 16(12):10324-10336.
Yi, Yang; Liao, Sen-Tai; Zhang, Ming-Wei; Zhang, Rui-Fen; Deng, Yuan-Yuan; Yang, Bao; Wei, Zhen-Cheng. 2011. "Immunomodulatory Activity of Polysaccharide-Protein Complex of Longan (Dimocarpus longan Lour.) Pulp." Molecules 16, no. 12: 10324-10336.