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Immunomodulatory Activity of Polysaccharide-Protein Complex of Longan (Dimocarpus longan Lour.) Pulp
Key Laboratory of Functional Food, Ministry of Agriculture, Bio-Tech Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510610, China
College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China
South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China
* Author to whom correspondence should be addressed.
Received: 7 November 2011; in revised form: 4 December 2011 / Accepted: 6 December 2011 / Published: 13 December 2011
Abstract: The immunomodulatory function of longan pulp polysaccharide-protein complex (LP3) was investigated in immunosuppressed mice models. Compared with the model control, peroral administration of 100 mgkg−1d−1 LP3 could significantly increase/enhance antibody production against chicken red blood cell (CRBC), concanavalin A (ConA)-induced splenocyte proliferation, macrophage phagocytosis, NK cell cytotoxicity against YAC-1 lymphoma cell, and interferon-gamma (INF-γ) and interleukin-2 (IL-2) secretion in serum (P < 0.05). The immunomodulatory effects, except for those on splenocytes and macrophages (P > 0.05), were also observed in mice administered with 50 or 200 mgkg−1d−1 LP3 (P < 0.05). The beneficial effects of 50–200 mgkg−1d−1 LP3 were comparable to those of 50 mgkg−1d−1 ganoderan. The strong immunomodulatory activity of LP3 confirmed its good potential as an immunotherapeutic adjuvant.
Keywords: longan pulp; polysaccharide-protein complex; immunomodulatory activity; immunosuppressed mice; cyclophosphamide
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MDPI and ACS Style
Yi, Y.; Liao, S.-T.; Zhang, M.-W.; Zhang, R.-F.; Deng, Y.-Y.; Yang, B.; Wei, Z.-C. Immunomodulatory Activity of Polysaccharide-Protein Complex of Longan (Dimocarpus longan Lour.) Pulp. Molecules 2011, 16, 10324-10336.
Yi Y, Liao S-T, Zhang M-W, Zhang R-F, Deng Y-Y, Yang B, Wei Z-C. Immunomodulatory Activity of Polysaccharide-Protein Complex of Longan (Dimocarpus longan Lour.) Pulp. Molecules. 2011; 16(12):10324-10336.
Yi, Yang; Liao, Sen-Tai; Zhang, Ming-Wei; Zhang, Rui-Fen; Deng, Yuan-Yuan; Yang, Bao; Wei, Zhen-Cheng. 2011. "Immunomodulatory Activity of Polysaccharide-Protein Complex of Longan (Dimocarpus longan Lour.) Pulp." Molecules 16, no. 12: 10324-10336.