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Molecules 2011, 16(12), 10324-10336; doi:10.3390/molecules161210324
Article

Immunomodulatory Activity of Polysaccharide-Protein Complex of Longan (Dimocarpus longan Lour.) Pulp

1,2, 1, 1,* , 1, 1, 3 and 1
Received: 7 November 2011; in revised form: 4 December 2011 / Accepted: 6 December 2011 / Published: 13 December 2011
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Abstract: The immunomodulatory function of longan pulp polysaccharide-protein complex (LP3) was investigated in immunosuppressed mice models. Compared with the model control, peroral administration of 100 mgkg−1d−1 LP3 could significantly increase/enhance antibody production against chicken red blood cell (CRBC), concanavalin A (ConA)-induced splenocyte proliferation, macrophage phagocytosis, NK cell cytotoxicity against YAC-1 lymphoma cell, and interferon-gamma (INF-γ) and interleukin-2 (IL-2) secretion in serum (P < 0.05). The immunomodulatory effects, except for those on splenocytes and macrophages (P > 0.05), were also observed in mice administered with 50 or 200 mgkg−1d−1 LP3 (P < 0.05). The beneficial effects of 50–200 mgkg−1d−1 LP3 were comparable to those of 50 mgkg−1d−1 ganoderan. The strong immunomodulatory activity of LP3 confirmed its good potential as an immunotherapeutic adjuvant.
Keywords: longan pulp; polysaccharide-protein complex; immunomodulatory activity; immunosuppressed mice; cyclophosphamide longan pulp; polysaccharide-protein complex; immunomodulatory activity; immunosuppressed mice; cyclophosphamide
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Yi, Y.; Liao, S.-T.; Zhang, M.-W.; Zhang, R.-F.; Deng, Y.-Y.; Yang, B.; Wei, Z.-C. Immunomodulatory Activity of Polysaccharide-Protein Complex of Longan (Dimocarpus longan Lour.) Pulp. Molecules 2011, 16, 10324-10336.

AMA Style

Yi Y, Liao S-T, Zhang M-W, Zhang R-F, Deng Y-Y, Yang B, Wei Z-C. Immunomodulatory Activity of Polysaccharide-Protein Complex of Longan (Dimocarpus longan Lour.) Pulp. Molecules. 2011; 16(12):10324-10336.

Chicago/Turabian Style

Yi, Yang; Liao, Sen-Tai; Zhang, Ming-Wei; Zhang, Rui-Fen; Deng, Yuan-Yuan; Yang, Bao; Wei, Zhen-Cheng. 2011. "Immunomodulatory Activity of Polysaccharide-Protein Complex of Longan (Dimocarpus longan Lour.) Pulp." Molecules 16, no. 12: 10324-10336.



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