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Molecules 2011, 16(12), 10324-10336; doi:10.3390/molecules161210324
Article

Immunomodulatory Activity of Polysaccharide-Protein Complex of Longan (Dimocarpus longan Lour.) Pulp

1,2, 1, 1,* , 1, 1, 3 and 1
1 Key Laboratory of Functional Food, Ministry of Agriculture, Bio-Tech Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510610, China 2 College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China 3 South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China
* Author to whom correspondence should be addressed.
Received: 7 November 2011 / Revised: 4 December 2011 / Accepted: 6 December 2011 / Published: 13 December 2011
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Abstract

The immunomodulatory function of longan pulp polysaccharide-protein complex (LP3) was investigated in immunosuppressed mice models. Compared with the model control, peroral administration of 100 mgkg−1d−1 LP3 could significantly increase/enhance antibody production against chicken red blood cell (CRBC), concanavalin A (ConA)-induced splenocyte proliferation, macrophage phagocytosis, NK cell cytotoxicity against YAC-1 lymphoma cell, and interferon-gamma (INF-γ) and interleukin-2 (IL-2) secretion in serum (P < 0.05). The immunomodulatory effects, except for those on splenocytes and macrophages (P > 0.05), were also observed in mice administered with 50 or 200 mgkg−1d−1 LP3 (P < 0.05). The beneficial effects of 50–200 mgkg−1d−1 LP3 were comparable to those of 50 mgkg−1d−1 ganoderan. The strong immunomodulatory activity of LP3 confirmed its good potential as an immunotherapeutic adjuvant.
Keywords: longan pulp; polysaccharide-protein complex; immunomodulatory activity; immunosuppressed mice; cyclophosphamide longan pulp; polysaccharide-protein complex; immunomodulatory activity; immunosuppressed mice; cyclophosphamide
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Yi, Y.; Liao, S.-T.; Zhang, M.-W.; Zhang, R.-F.; Deng, Y.-Y.; Yang, B.; Wei, Z.-C. Immunomodulatory Activity of Polysaccharide-Protein Complex of Longan (Dimocarpus longan Lour.) Pulp. Molecules 2011, 16, 10324-10336.

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