Molecules 2011, 16(11), 9620-9635; doi:10.3390/molecules16119620
Article

Eco-Friendly Methodology to Prepare N-Heterocycles Related to Dihydropyridines: Microwave-Assisted Synthesis of Alkyl 4-Arylsubstituted-6-chloro-5-formyl-2-methyl-1,4-dihydropyridine-3-carboxylate and 4-Arylsubstituted-4,7-dihydrofuro[3,4-b]pyridine-2,5(1H,3H)-dione

1 Laboratory of Organic Chemistry, Department of Organic Chemistry, Chemistry Faculty, University of Havana, 10400, Cuba 2 Institute for Research in Biomedicine, Barcelona Science Park, Baldiri Reixac 10, 08028 Barcelona, Spain 3 Department of Organic Chemistry, Chemistry Faculty, Universidad Complutense, 28040 Madrid, Spain 4 CIBER-BBN, Networking Centre on Bioengineering, Biomaterials and Nanomedicine, Barcelona Science Park, Baldiri Reixac 10, 08028 Barcelona, Spain 5 Department of Organic Chemistry, University of Barcelona, Martí i Franqués 1-11, 08028 Barcelona, Spain
* Authors to whom correspondence should be addressed.
Received: 10 October 2011; in revised form: 26 October 2011 / Accepted: 15 November 2011 / Published: 21 November 2011
(This article belongs to the Section Organic Synthesis)
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Abstract: Here we describe the efficient synthesis of alkyl 4-arylsubstituted-6-chloro-5-formyl-2-methyl-1,4-dihydropyridine-3-carboxylates and 4-arylsubstituted-4,7-dihydro-furo[3,4-b]pyridine-2,5(1H,3H)-diones via microwave-accelerated reaction of alkyl 4-arylsubstituted-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxylates with the appropriate reagents. This eco-friendly approach to these valuable dihydropyridine derivatives does not involve the harsh or highly contaminating conditions common in classical heating and offers a reduction or even elimination of solvent use and recovery, simplification of the work-up procedures, facility of scale up, and low energy consumption, in addition to moderate to higher yields.
Keywords: microwave; dihydropyridines; green chemistry

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MDPI and ACS Style

Rodríguez, H.; Martin, O.; Suarez, M.; Martín, N.; Albericio, F. Eco-Friendly Methodology to Prepare N-Heterocycles Related to Dihydropyridines: Microwave-Assisted Synthesis of Alkyl 4-Arylsubstituted-6-chloro-5-formyl-2-methyl-1,4-dihydropyridine-3-carboxylate and 4-Arylsubstituted-4,7-dihydrofuro[3,4-b]pyridine-2,5(1H,3H)-dione. Molecules 2011, 16, 9620-9635.

AMA Style

Rodríguez H, Martin O, Suarez M, Martín N, Albericio F. Eco-Friendly Methodology to Prepare N-Heterocycles Related to Dihydropyridines: Microwave-Assisted Synthesis of Alkyl 4-Arylsubstituted-6-chloro-5-formyl-2-methyl-1,4-dihydropyridine-3-carboxylate and 4-Arylsubstituted-4,7-dihydrofuro[3,4-b]pyridine-2,5(1H,3H)-dione. Molecules. 2011; 16(11):9620-9635.

Chicago/Turabian Style

Rodríguez, Hortensia; Martin, Osnieski; Suarez, Margarita; Martín, Nazario; Albericio, Fernando. 2011. "Eco-Friendly Methodology to Prepare N-Heterocycles Related to Dihydropyridines: Microwave-Assisted Synthesis of Alkyl 4-Arylsubstituted-6-chloro-5-formyl-2-methyl-1,4-dihydropyridine-3-carboxylate and 4-Arylsubstituted-4,7-dihydrofuro[3,4-b]pyridine-2,5(1H,3H)-dione." Molecules 16, no. 11: 9620-9635.

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