Next Article in Journal
Previous Article in Journal
Molecules 2011, 16(11), 9421-9438; doi:10.3390/molecules16119421
Article

Indatraline: Synthesis and Effect on the Motor Activity of Wistar Rats

1
, 2
, 1
, 2,*  and 1,*
Received: 17 October 2011; in revised form: 3 November 2011 / Accepted: 7 November 2011 / Published: 10 November 2011
Download PDF [599 KB, uploaded 18 June 2014]
Abstract: A new approach for the synthesis of indatraline was developed using as the key step an iodine(III)-mediated ring contraction of a 1,2-dihydronaphthalene derivative. Behavioral tests were conducted to evaluate the effect of indatraline and of its precursor indanamide on the motor activity of Wistar rats. Specific indexes for ambulation, raising and stereotypy were computed one, two and three hours after i.p. drug administration. Indatraline effects on motor activity lasted for at least three hours. On the other hand, no significant differences in motor activity were observed using indanamide. The results suggest that indatraline has a long lasting effect on motor activity and add evidence in favor of the potential use of that compound as a substitute in cocaine addiction.
Keywords: indatraline; cocaine abuse; ring contraction; motor activity; Wistar rats indatraline; cocaine abuse; ring contraction; motor activity; Wistar rats
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Kameyama, M.; Siqueira, F.A.; Garcia-Mijares, M.; F. Silva, Jr., L.; Silva, M.T.A. Indatraline: Synthesis and Effect on the Motor Activity of Wistar Rats. Molecules 2011, 16, 9421-9438.

AMA Style

Kameyama M, Siqueira FA, Garcia-Mijares M, F. Silva, Jr. L, Silva MTA. Indatraline: Synthesis and Effect on the Motor Activity of Wistar Rats. Molecules. 2011; 16(11):9421-9438.

Chicago/Turabian Style

Kameyama, Márcia; Siqueira, Fernanda A.; Garcia-Mijares, Miriam; F. Silva, Jr., Luiz; Silva, Maria T. A. 2011. "Indatraline: Synthesis and Effect on the Motor Activity of Wistar Rats." Molecules 16, no. 11: 9421-9438.



Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert