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Molecules 2011, 16(11), 9421-9438; doi:10.3390/molecules16119421

Indatraline: Synthesis and Effect on the Motor Activity of Wistar Rats

Department of Experimental Psychology, Institute of Psychology, University of São Paulo, USP, Av. Prof. Mello de Moraes, 1721, Cidade Universitária, São Paulo SP CEP 05508-030, Brazil
Departamento de Química Fundamental, Instituto de Química, Universidade de São Paulo, CP 26077, São Paulo-SP, 05513-970, Brazil
Authors to whom correspondence should be addressed.
Received: 17 October 2011 / Revised: 3 November 2011 / Accepted: 7 November 2011 / Published: 10 November 2011
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A new approach for the synthesis of indatraline was developed using as the key step an iodine(III)-mediated ring contraction of a 1,2-dihydronaphthalene derivative. Behavioral tests were conducted to evaluate the effect of indatraline and of its precursor indanamide on the motor activity of Wistar rats. Specific indexes for ambulation, raising and stereotypy were computed one, two and three hours after i.p. drug administration. Indatraline effects on motor activity lasted for at least three hours. On the other hand, no significant differences in motor activity were observed using indanamide. The results suggest that indatraline has a long lasting effect on motor activity and add evidence in favor of the potential use of that compound as a substitute in cocaine addiction.
Keywords: indatraline; cocaine abuse; ring contraction; motor activity; Wistar rats indatraline; cocaine abuse; ring contraction; motor activity; Wistar rats

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Kameyama, M.; Siqueira, F.A.; Garcia-Mijares, M.; F. Silva, Jr., L.; Silva, M.T.A. Indatraline: Synthesis and Effect on the Motor Activity of Wistar Rats. Molecules 2011, 16, 9421-9438.

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