A New Eudesmane Sesquiterpene Glucoside from Liriope muscari Fibrous Roots
Abstract
:1. Introduction
2. Results and Discussion
2.1. Chemistry
2.2. Biological Activity
Treatments | Concentrations (μg/mL) | 72 h LC50 (μg/mL) | 95% Fiducial limits | Chi-Square Tests (χ2) |
---|---|---|---|---|
Ethanol extract | 50.00–800.00 | 182.56 | 19.79–24.46 | 9.45 |
1 | 50.00–800.00 | 82.84 | 76.80–93.49 | 1.95 |
2 | 50.00–800.00 | 153.39 | 140.44–169.46 | 5.83 |
3 | 50.00–800.00 | 339.76 | 302.99–366.65 | 3.97 |
4 | 50.00–800.00 | 465.68 | 435.88–508.33 | 2.28 |
Carbofuran | 1.50–50.00 | 3.76 | 2.62–4.99 | 3.78 |
3. Experimental
3.1. General
3.2. Plant Material
3.3. Extraction and Isolation of Active Ingredients
3.5. Compound Characterization
3.2. Nematocidal Assay
4. Conclusions
Supplementary Materials
Acknowledgments
References and Notes
- Flora of China; Committee of Flora of China, Science Press: Beijing, China, 1978; Volume 15, pp. 128–130, Number 2.
- Jiangsu New Medical College, Encyclopedia of Chinese Medicinal Substances; Shanghai People’s Publisher: Shanghai, China, 1986; p. 2082.
- Yu, B.Y.; Xu, G.J.; Jin, R.L.; Xu, L.S. Drug resources and identification of commercial drugs on Radix Ophiopogonis. Chung-kuo Yao ko ta Hsueh Hsueh Pao 1991, 22, 150–153, (in Chinese with English abstract). [Google Scholar]
- Tian, Y.Q.; Kou, J.P.; Li, L.Z.; Yu, B.Y. Anti-inflammatory effects of aqueous extract from Radix Liriope muscari and its major active fraction and component. Chin. J. Nat. Med. 2011, 9, 222–226. [Google Scholar]
- Yu, B.Y.; Hirai, Y.; Shoji, J.Z.; Xu, G.J. Comparative studies on the constituents of ophiopogonis tuber and its congeners. VI. Studies on the constituents of the subterranean part of Liriope spicata var. prolifera and L. muscari. Chem. Pharm. Bull. 1990, 38, 1931–1935. [Google Scholar] [CrossRef]
- Yu, B.Y.; Yin, X.; Rong, Z.Y.; Yang, T.M.; Zhang, C.H.; Xu, G.J. Biological activities of ruscogenin 1-O-[β-D-glucopyranosyl (1→2)] [β-D-xylopyranosyl (1→3)]-β-D-fucopyranoside from tuberous roots of Liriope muscari (Deene.) Bailey. Chung-kuo Yao ko ta Hsueh Hsueh Pao 1994, 25, 286–288. [Google Scholar]
- Wu, F.H.; Cao, J.S.; Jiang, J.Y.; Yu, B.Y.; Xu, Q. Ruscogenin glycoside (Lm-3) isolated from Liriope muscari improves liver injury by dysfunctioning liver-infiltrating lymphocytes. J. Pharm. Pharmacol. 2001, 53, 681–688. [Google Scholar]
- Liu, J.L.; Chen, T.; Yu, B.Y.; Xu, Q. Ruscogenin glycoside (Lm-3) isolated from Liriope muscari inhibits lymphocyte adhesion to extracellular matrix. J. Pharm. Pharmacol. 2002, 54, 959–966. [Google Scholar]
- Cheng, Z.H.; Wu, T.; Bligh, S.W.A.; Bashall, A.; Yu, B.Y. cis-Eudesmane sesquiterpene glycosides from Liriope muscari and Ophiopogon japonicus. J. Nat. Prod. 2004, 67, 1761–1763. [Google Scholar] [CrossRef]
- Cheng, Z.H.; Wu, T.; Yu, B.Y.; Xu, L.S. Studies on Chemical constituents of Liriope muscari. Zhong Cao Yao 2005, 36, 823–826, (in Chinese with English abstract). [Google Scholar]
- Cheng, Z.H.; Wu, T.; Guo, Y.L.; Yu, B.Y.; Xu, L.S. Two new steroidal glycosides from Liriope muscari. Chin. Chem. Lett. 2006, 17, 31–34. [Google Scholar]
- Lee, S.E.; Lee, B.H.; Choi, W.S.; Park, B.S.; Kim, J.G.; Campbell, B.C. Fumigant toxicity of volatile natural products from Korean spices and medicinal plants towards the rice weevil, Sitophilus oryzae (L.). Pest Manag. Sci. 2001, 57, 548–553. [Google Scholar] [CrossRef]
- Viglierchio, D.R.; Schmit, R.V. On the methodology of nematode extraction from field samples: Baermann funnel modifications. J. Nematol. 1983, 15, 438–444. [Google Scholar]
- Sakuma, M. Probit analysis of preference data. Appl. Entomol. Zool. 1998, 33, 339–347. [Google Scholar]
- Hak, C.K.; Ock, R.C.; Kang, C.L.; Kang, R.L. Cerebrosides and terpene glycosides from the root of Aster scaber. Arch. Pharm. Res. 2003, 26, 132–137. [Google Scholar] [CrossRef]
- Hua, Y.; Zhou, J.; Chen, C.X. A new eudesmane sesquiterpene glycoside from Parepigynum funingense. Chin. Chem. Lett. 2007, 18, 73–75. [Google Scholar] [CrossRef]
- Sample Availability: Samples of the crude extracts and pure compounds are available from the authors.
© 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license ( http://creativecommons.org/licenses/by/3.0/).
Share and Cite
Zhang, H.M.; Wang, G.L.; Bai, C.Q.; Liu, P.; Liu, Z.M.; Liu, Q.Z.; Wang, Y.Y.; Liu, Z.L.; Du, S.S.; Deng, Z.W. A New Eudesmane Sesquiterpene Glucoside from Liriope muscari Fibrous Roots. Molecules 2011, 16, 9017-9024. https://doi.org/10.3390/molecules16119017
Zhang HM, Wang GL, Bai CQ, Liu P, Liu ZM, Liu QZ, Wang YY, Liu ZL, Du SS, Deng ZW. A New Eudesmane Sesquiterpene Glucoside from Liriope muscari Fibrous Roots. Molecules. 2011; 16(11):9017-9024. https://doi.org/10.3390/molecules16119017
Chicago/Turabian StyleZhang, Hai Ming, Gang Li Wang, Chun Qi Bai, Peng Liu, Zi Mu Liu, Qi Zhi Liu, Yong Yan Wang, Zhi Long Liu, Shu Shan Du, and Zhi Wei Deng. 2011. "A New Eudesmane Sesquiterpene Glucoside from Liriope muscari Fibrous Roots" Molecules 16, no. 11: 9017-9024. https://doi.org/10.3390/molecules16119017