Molecules 2011, 16(11), 8945-8957; doi:10.3390/molecules16118945
Article

Design, Synthesis and Antifungal/Insecticidal Evaluation of Novel Cinnamide Derivatives

1, 1, 2, 3, 2, 1,* email and 1,* email
Received: 12 August 2011; in revised form: 2 October 2011 / Accepted: 11 October 2011 / Published: 25 October 2011
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Twenty novel cinnamamide derivatives were designed and synthesized using as lead compound pyrimorph, whose morpholine moiety was replaced by β-phenylethylamine. All the compounds were characterized by their spectroscopic data. The fungicidal and insecticidal activities were also evaluated. The preliminary results showed that all the title compounds had certain fungicidal activities against seven plant pathogens at a concentration of 50 μg/mL, and compounds 11a and 11l showed inhibition ratios of up to 90% against R. solani. Most of the title compounds exhibited moderate nematicidal activities. In general, the morpholine ring may be replaced by other amines and a chlorine atom in the pyridine ring is helpful to fungicidal activity.
Keywords: cinnamide; β-phenyl ethylamine; fungicidal activity; insecticidal activity
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MDPI and ACS Style

Xiao, Y.; Yang, X.; Li, B.; Yuan, H.; Wan, S.; Xu, Y.; Qin, Z. Design, Synthesis and Antifungal/Insecticidal Evaluation of Novel Cinnamide Derivatives. Molecules 2011, 16, 8945-8957.

AMA Style

Xiao Y, Yang X, Li B, Yuan H, Wan S, Xu Y, Qin Z. Design, Synthesis and Antifungal/Insecticidal Evaluation of Novel Cinnamide Derivatives. Molecules. 2011; 16(11):8945-8957.

Chicago/Turabian Style

Xiao, Yumei; Yang, Xiaoli; Li, Bo; Yuan, Huizhu; Wan, Shuqing; Xu, Yanjun; Qin, Zhaohai. 2011. "Design, Synthesis and Antifungal/Insecticidal Evaluation of Novel Cinnamide Derivatives." Molecules 16, no. 11: 8945-8957.


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