Design, Synthesis and Antifungal/Insecticidal Evaluation of Novel Cinnamide Derivatives

doi:10.3390/molecules16118945

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Molecules 2011, 16(11), 8945-8957; doi:10.3390/molecules16118945

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Design, Synthesis and Antifungal/Insecticidal Evaluation of Novel Cinnamide Derivatives

Yumei Xiao¹, Xiaoli Yang¹, Bo Li², Huizhu Yuan³, Shuqing Wan², Yanjun Xu^1,* and Zhaohai Qin^1,*

¹ College of Science, China Agricultural University, Beijing 100193, China ² Lab of Insect Toxicology, South China Agricultural University, Guangzhou 510642, China ³ Institute of Plant Protection, Chinese Academ y of Agriculture Science, Beijing 10193, China

* Authors to whom correspondence should be addressed.

Received: 12 August 2011; in revised form: 2 October 2011 / Accepted: 11 October 2011 / Published: 25 October 2011

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Abstract: Twenty novel cinnamamide derivatives were designed and synthesized using as lead compound pyrimorph, whose morpholine moiety was replaced by β-phenylethylamine. All the compounds were characterized by their spectroscopic data. The fungicidal and insecticidal activities were also evaluated. The preliminary results showed that all the title compounds had certain fungicidal activities against seven plant pathogens at a concentration of 50 μg/mL, and compounds 11a and 11l showed inhibition ratios of up to 90% against R. solani. Most of the title compounds exhibited moderate nematicidal activities. In general, the morpholine ring may be replaced by other amines and a chlorine atom in the pyridine ring is helpful to fungicidal activity.

Keywords: cinnamide; β-phenyl ethylamine; fungicidal activity; insecticidal activity

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Cite This Article

MDPI and ACS Style

Xiao, Y.; Yang, X.; Li, B.; Yuan, H.; Wan, S.; Xu, Y.; Qin, Z. Design, Synthesis and Antifungal/Insecticidal Evaluation of Novel Cinnamide Derivatives. Molecules 2011, 16, 8945-8957.

AMA Style

Xiao Y, Yang X, Li B, Yuan H, Wan S, Xu Y, Qin Z. Design, Synthesis and Antifungal/Insecticidal Evaluation of Novel Cinnamide Derivatives. Molecules. 2011; 16(11):8945-8957.

Chicago/Turabian Style

Xiao, Yumei; Yang, Xiaoli; Li, Bo; Yuan, Huizhu; Wan, Shuqing; Xu, Yanjun; Qin, Zhaohai. 2011. "Design, Synthesis and Antifungal/Insecticidal Evaluation of Novel Cinnamide Derivatives." Molecules 16, no. 11: 8945-8957.

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