Next Article in Journal
Triazolobithiophene Light Absorbing Self-Assembled Monolayers: Synthesis and Mass Spectrometry Applications
Next Article in Special Issue
Synthesis, Acidity Constants and Tautomeric Structure of the Diazonium Coupling Products of 2-(Benzylsulfanyl)-7H-purin-6-one in Its Ground and Excited States
Previous Article in Journal
Efficient Microwave-Assisted Synthesis of Ionic Esterified Amino Acids
Previous Article in Special Issue
Synthesis and in Vitro Antimicrobial Activity of Some Pyrazolyl-1-carboxamide Derivatives
Molecules 2011, 16(10), 8745-8757; doi:10.3390/molecules16108745
Article

Facile Synthesis of Functionalized Spiropyrrolizidine Oxindoles via a Three-Component Tandem Cycloaddition Reaction

1
, 1
, 1
, 1
, 1,*  and 2,*
Received: 26 August 2011; in revised form: 30 September 2011 / Accepted: 3 October 2011 / Published: 19 October 2011
(This article belongs to the Special Issue Heterocycles)
Download PDF [323 KB, uploaded 18 June 2014]
Abstract: An efficient synthesis of functionalized spiropyrrolizidine oxindoles via a three-component tandem cycloaddition has been achieved. This strategy can provide direct and rapid access to spiropyrrolizidine oxindoles in high yields (up to 99%) with excellent diastereoselectivities (up to 99:1 dr). The features of this procedure are the following: mild reaction conditions, high yields, high diastereoselectivities, one-pot procedure and operational simplicity.
Keywords: spiropyrrolizidine oxindoles; cycloaddition; isatin spiropyrrolizidine oxindoles; cycloaddition; isatin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Xie, Y.-M.; Yao, Y.-Q.; Sun, H.-B.; Yan, T.-T.; Liu, J.; Kang, T.-R. Facile Synthesis of Functionalized Spiropyrrolizidine Oxindoles via a Three-Component Tandem Cycloaddition Reaction. Molecules 2011, 16, 8745-8757.

AMA Style

Xie Y-M, Yao Y-Q, Sun H-B, Yan T-T, Liu J, Kang T-R. Facile Synthesis of Functionalized Spiropyrrolizidine Oxindoles via a Three-Component Tandem Cycloaddition Reaction. Molecules. 2011; 16(10):8745-8757.

Chicago/Turabian Style

Xie, Yong-Mei; Yao, Yu-Qin; Sun, Hong-Bao; Yan, Ting-Ting; Liu, Jie; Kang, Tai-Ran. 2011. "Facile Synthesis of Functionalized Spiropyrrolizidine Oxindoles via a Three-Component Tandem Cycloaddition Reaction." Molecules 16, no. 10: 8745-8757.


Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert