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Molecules 2011, 16(10), 8745-8757; doi:10.3390/molecules16108745

Facile Synthesis of Functionalized Spiropyrrolizidine Oxindoles via a Three-Component Tandem Cycloaddition Reaction

State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, China
Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, College of Chemistry and Chemical Engineering, China West Normal University, Nanchong, 637002, China
Authors to whom correspondence should be addressed.
Received: 26 August 2011 / Revised: 30 September 2011 / Accepted: 3 October 2011 / Published: 19 October 2011
(This article belongs to the Special Issue Heterocycles)
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An efficient synthesis of functionalized spiropyrrolizidine oxindoles via a three-component tandem cycloaddition has been achieved. This strategy can provide direct and rapid access to spiropyrrolizidine oxindoles in high yields (up to 99%) with excellent diastereoselectivities (up to 99:1 dr). The features of this procedure are the following: mild reaction conditions, high yields, high diastereoselectivities, one-pot procedure and operational simplicity.
Keywords: spiropyrrolizidine oxindoles; cycloaddition; isatin spiropyrrolizidine oxindoles; cycloaddition; isatin
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Xie, Y.-M.; Yao, Y.-Q.; Sun, H.-B.; Yan, T.-T.; Liu, J.; Kang, T.-R. Facile Synthesis of Functionalized Spiropyrrolizidine Oxindoles via a Three-Component Tandem Cycloaddition Reaction. Molecules 2011, 16, 8745-8757.

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