Molecules 2011, 16(10), 8745-8757; doi:10.3390/molecules16108745
Article

Facile Synthesis of Functionalized Spiropyrrolizidine Oxindoles via a Three-Component Tandem Cycloaddition Reaction

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Received: 26 August 2011; in revised form: 30 September 2011 / Accepted: 3 October 2011 / Published: 19 October 2011
(This article belongs to the Special Issue Heterocycles)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: An efficient synthesis of functionalized spiropyrrolizidine oxindoles via a three-component tandem cycloaddition has been achieved. This strategy can provide direct and rapid access to spiropyrrolizidine oxindoles in high yields (up to 99%) with excellent diastereoselectivities (up to 99:1 dr). The features of this procedure are the following: mild reaction conditions, high yields, high diastereoselectivities, one-pot procedure and operational simplicity.
Keywords: spiropyrrolizidine oxindoles; cycloaddition; isatin
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MDPI and ACS Style

Xie, Y.-M.; Yao, Y.-Q.; Sun, H.-B.; Yan, T.-T.; Liu, J.; Kang, T.-R. Facile Synthesis of Functionalized Spiropyrrolizidine Oxindoles via a Three-Component Tandem Cycloaddition Reaction. Molecules 2011, 16, 8745-8757.

AMA Style

Xie Y-M, Yao Y-Q, Sun H-B, Yan T-T, Liu J, Kang T-R. Facile Synthesis of Functionalized Spiropyrrolizidine Oxindoles via a Three-Component Tandem Cycloaddition Reaction. Molecules. 2011; 16(10):8745-8757.

Chicago/Turabian Style

Xie, Yong-Mei; Yao, Yu-Qin; Sun, Hong-Bao; Yan, Ting-Ting; Liu, Jie; Kang, Tai-Ran. 2011. "Facile Synthesis of Functionalized Spiropyrrolizidine Oxindoles via a Three-Component Tandem Cycloaddition Reaction." Molecules 16, no. 10: 8745-8757.

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