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Molecules 2011, 16(10), 8745-8757; doi:10.3390/molecules16108745
Article

Facile Synthesis of Functionalized Spiropyrrolizidine Oxindoles via a Three-Component Tandem Cycloaddition Reaction

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1,*  and 2,*
1 State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, China 2 Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, College of Chemistry and Chemical Engineering, China West Normal University, Nanchong, 637002, China
* Authors to whom correspondence should be addressed.
Received: 26 August 2011 / Revised: 30 September 2011 / Accepted: 3 October 2011 / Published: 19 October 2011
(This article belongs to the Special Issue Heterocycles)
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Abstract

An efficient synthesis of functionalized spiropyrrolizidine oxindoles via a three-component tandem cycloaddition has been achieved. This strategy can provide direct and rapid access to spiropyrrolizidine oxindoles in high yields (up to 99%) with excellent diastereoselectivities (up to 99:1 dr). The features of this procedure are the following: mild reaction conditions, high yields, high diastereoselectivities, one-pot procedure and operational simplicity.
Keywords: spiropyrrolizidine oxindoles; cycloaddition; isatin spiropyrrolizidine oxindoles; cycloaddition; isatin
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Xie, Y.-M.; Yao, Y.-Q.; Sun, H.-B.; Yan, T.-T.; Liu, J.; Kang, T.-R. Facile Synthesis of Functionalized Spiropyrrolizidine Oxindoles via a Three-Component Tandem Cycloaddition Reaction. Molecules 2011, 16, 8745-8757.

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