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Efficient Microwave-Assisted Synthesis of Ionic Esterified Amino Acids
Dirección de Investigación y Posgrado, Instituto Mexicano del Petróleo, Eje Central Lázaro Cárdenas 152, 07730 Mexico City, Mexico
* Author to whom correspondence should be addressed.
Received: 16 September 2011; in revised form: 11 October 2011 / Accepted: 14 October 2011 / Published: 19 October 2011
Abstract: In this work, an efficient microwave-assisted methodology for the esterification of unprotected α-amino acids is described. Ionic esterified amino acids were synthesized in satisfactory yields in a facile one-pot solventless protocol from unprotected amino acids and alcohols under acid catalysis (MsOH or p-TsOH) to afford the pure products after a simple work-up procedure. This procedure can also be extended to the preparation of long and short chain alkyl and benzyl esters.
Keywords: amino acids; esterification; microwave; parallel synthesis
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MDPI and ACS Style
Cerón-Camacho, R.; Aburto, J.; Montiel, L.E.; Flores, E.A.; Cuellar, F.; Martínez-Palou, R. Efficient Microwave-Assisted Synthesis of Ionic Esterified Amino Acids. Molecules 2011, 16, 8733-8744.
Cerón-Camacho R, Aburto J, Montiel LE, Flores EA, Cuellar F, Martínez-Palou R. Efficient Microwave-Assisted Synthesis of Ionic Esterified Amino Acids. Molecules. 2011; 16(10):8733-8744.
Cerón-Camacho, Ricardo; Aburto, Jorge; Montiel, Luisa E.; Flores, Eugenio A.; Cuellar, Frisia; Martínez-Palou, Rafael. 2011. "Efficient Microwave-Assisted Synthesis of Ionic Esterified Amino Acids." Molecules 16, no. 10: 8733-8744.