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Molecules 2011, 16(10), 8733-8744; https://doi.org/10.3390/molecules16108733

Efficient Microwave-Assisted Synthesis of Ionic Esterified Amino Acids

Dirección de Investigación y Posgrado, Instituto Mexicano del Petróleo, Eje Central Lázaro Cárdenas 152, 07730 Mexico City, Mexico
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Received: 16 September 2011 / Revised: 11 October 2011 / Accepted: 14 October 2011 / Published: 19 October 2011
(This article belongs to the Special Issue Microwave Assisted Synthesis)
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Abstract

In this work, an efficient microwave-assisted methodology for the esterification of unprotected α-amino acids is described. Ionic esterified amino acids were synthesized in satisfactory yields in a facile one-pot solventless protocol from unprotected amino acids and alcohols under acid catalysis (MsOH or p-TsOH) to afford the pure products after a simple work-up procedure. This procedure can also be extended to the preparation of long and short chain alkyl and benzyl esters.
Keywords: amino acids; esterification; microwave; parallel synthesis amino acids; esterification; microwave; parallel synthesis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Cerón-Camacho, R.; Aburto, J.; Montiel, L.E.; Flores, E.A.; Cuellar, F.; Martínez-Palou, R. Efficient Microwave-Assisted Synthesis of Ionic Esterified Amino Acids. Molecules 2011, 16, 8733-8744.

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