Molecules 2011, 16(10), 8646-8653; doi:10.3390/molecules16108646
Article

Two New Epoxysteroids from Helianthus tuberosus

Xiao-Dong Liemail, Feng-Ping Miaoemail and Nai-Yun Ji* email
Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China
* Author to whom correspondence should be addressed.
Received: 5 September 2011; in revised form: 10 October 2011 / Accepted: 11 October 2011 / Published: 13 October 2011
(This article belongs to the Special Issue Steroids)
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Abstract: Two new epoxy steroids, 5α,8α-epidioxy-22β,23β-epoxyergosta-6-en-3β-ol (1) and 5α,8α-epidioxy-22α,23α-epoxyergosta-6-en-3β-ol (2), and ten known steroids including (24R)-5α,8α-epidioxyergosta-6-en-3β-ol (3), (22E,24R)-5α,8α-epidioxyergosta-6,22-dien-3β-ol (4), (22E,24R)-5α,8α-epidioxyergosta-6,9(11),22-trien-3β-ol (5), β-sitosterol (6), sitost-5-en-3β-ol acetate (7), 7α-hydroxysitosterol (8), schleicheol 2 (9), (24R)-24-ethyl-5α-cholestane-3β,5α,6β-triol (10), 7α-hydroxystigmasterol (11), and stigmasterol (12) were isolated from Helianthus tuberosus grown in Laizhou salinized land of coastal zone of Bohai Sea, China. The structures of these compounds were unambiguously established by 1D, 2D NMR and mass spectroscopic techniques. The new compounds 1 and 2 exhibited weak antibacterial activity and no antifungal activity.
Keywords: Helianthus tuberosus; steroid; 5α,8α-epidioxy-22β,23β-epoxyergosta-6-en-3β-ol; 5α,8α-epidioxy-22α,23α-epoxyergosta-6-en-3β-ol

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Cite This Article

MDPI and ACS Style

Li, X.-D.; Miao, F.-P.; Ji, N.-Y. Two New Epoxysteroids from Helianthus tuberosus. Molecules 2011, 16, 8646-8653.

AMA Style

Li X-D, Miao F-P, Ji N-Y. Two New Epoxysteroids from Helianthus tuberosus. Molecules. 2011; 16(10):8646-8653.

Chicago/Turabian Style

Li, Xiao-Dong; Miao, Feng-Ping; Ji, Nai-Yun. 2011. "Two New Epoxysteroids from Helianthus tuberosus." Molecules 16, no. 10: 8646-8653.

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