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Molecules 2011, 16(1), 774-789; doi:10.3390/molecules16010774
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The Discovery of Small-Molecule Mimicking Peptides through Phage Display

1
, 1
 and 2,*
1 Department of Food Engineering, Hacettepe University, Beytepe 06800, Ankara, Turkey 2 Division of Chemistry and Biological Chemistry, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore
* Author to whom correspondence should be addressed.
Received: 16 December 2010 / Revised: 12 January 2011 / Accepted: 18 January 2011 / Published: 19 January 2011
(This article belongs to the Special Issue Phage Display of Combinatorial Libraries)
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Abstract

Using peptides to achieve the functional and structural mimicry of small-molecules, especially those with biological activity or clear biotechnological applications, has great potential in overcoming difficulties associated with synthesis, or unfavorable physical properties. Combinatorial techniques like phage display can aid in the discovery of these peptides even if their mechanism of mimicry is not rationally obvious.The major focus of this field has been limited to developing biotin and sugar mimetics. However, the full “mimicry” of these peptides has not yet been fully established as some bind to the target with a different mechanism than that of the natural ligand and some do not share all of the natural ligand’s binding partners. In this article, mimicry of small-molecules by phage display-discovered peptides is reviewed and their potential in biochemical and medical applications is analyzed.
Keywords: phage display peptides;biotin mimics; sugar mimics phage display peptides; biotin mimics; sugar mimics
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Dudak, F.C.; Boyaci, I.H.; Orner, B.P. The Discovery of Small-Molecule Mimicking Peptides through Phage Display. Molecules 2011, 16, 774-789.

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