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Molecules 2011, 16(1), 762-773; doi:10.3390/molecules16010762
Communication

Schistosomicidal Activity of the Essential Oil of Ageratum conyzoides L. (Asteraceae) against Adult Schistosoma mansoni Worms

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Received: 19 November 2010; in revised form: 11 January 2011 / Accepted: 17 January 2011 / Published: 18 January 2011
(This article belongs to the Section Metabolites)
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Abstract: The in vitro schistosomicidal effects of the essential oil of Ageratum conyzoides L. (Ac-EO) against adult worms of Schistosoma mansoni is reported in this paper. Concerning this activity, Ac-EO was considered to be active, but less effective than the positive control (praziquantel, PZQ) in terms of separation of coupled pairs, mortality, decrease in motor activity, and tegumental alterations. However, Ac-EO caused an interesting dose-dependent reduction in the number of eggs of S. mansoni. Precocene I (74.30%) and (E)-caryophyllene (14.23%) were identified as the two major constituents of Ac-EO. These compounds were tested individually and were found to be much less effective than Ac-EO and PZQ. A mixture of the two major compounds in a ratio similar to that found in the Ac-EO was also less effective than Ac-EO, thus revealing that there are no synergistic effects between these components. These results suggest that the essential oil of A. conyzoides is very promising for the development of new schistosomicidal agents.
Keywords: Schistosoma; essential oil; Ageratum conyzoides Schistosoma; essential oil; Ageratum conyzoides
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

De Melo, N.I.; Magalhaes, L.G.; De Carvalho, C.E.; Wakabayashi, K.A.L.; De P. Aguiar, G.; Ramos, R.C.; Mantovani, A.L.L.; Turatti, I.C.C.; Rodrigues, V.; Groppo, M.; Cunha, W.R.; Veneziani, R.C.S.; Crotti, A.E.M. Schistosomicidal Activity of the Essential Oil of Ageratum conyzoides L. (Asteraceae) against Adult Schistosoma mansoni Worms. Molecules 2011, 16, 762-773.

AMA Style

De Melo NI, Magalhaes LG, De Carvalho CE, Wakabayashi KAL, De P. Aguiar G, Ramos RC, Mantovani ALL, Turatti ICC, Rodrigues V, Groppo M, Cunha WR, Veneziani RCS, Crotti AEM. Schistosomicidal Activity of the Essential Oil of Ageratum conyzoides L. (Asteraceae) against Adult Schistosoma mansoni Worms. Molecules. 2011; 16(1):762-773.

Chicago/Turabian Style

De Melo, Nathalya I.; Magalhaes, Lizandra G.; De Carvalho, Carlos E.; Wakabayashi, Kamila A. L.; De P. Aguiar, Gabriela; Ramos, Rafael C.; Mantovani, Andre L. L.; Turatti, Izabel C. C.; Rodrigues, Vanderlei; Groppo, Milton; Cunha, Wilson R.; Veneziani, Rodrigo C. S.; Crotti, Antônio E. M. 2011. "Schistosomicidal Activity of the Essential Oil of Ageratum conyzoides L. (Asteraceae) against Adult Schistosoma mansoni Worms." Molecules 16, no. 1: 762-773.


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