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Molecules 2011, 16(1), 762-773; doi:10.3390/molecules16010762

Schistosomicidal Activity of the Essential Oil of Ageratum conyzoides L. (Asteraceae) against Adult Schistosoma mansoni Worms

Núcleo de Pesquisas em Ciências Exatas e Tecnológicas, Universidade de Franca, CEP 14404-600, Franca, SP, Brazil
Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, CEP 14040-903 Ribeirão Preto, SP, Brazil
Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, CEP 14049-900 Ribeirão Preto, SP, Brazil
Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, CEP 14040-901 Ribeirão Preto, SP, Brazil
Author to whom correspondence should be addressed.
Received: 19 November 2010 / Revised: 11 January 2011 / Accepted: 17 January 2011 / Published: 18 January 2011
(This article belongs to the Section Natural Products)
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The in vitro schistosomicidal effects of the essential oil of Ageratum conyzoides L. (Ac-EO) against adult worms of Schistosoma mansoni is reported in this paper. Concerning this activity, Ac-EO was considered to be active, but less effective than the positive control (praziquantel, PZQ) in terms of separation of coupled pairs, mortality, decrease in motor activity, and tegumental alterations. However, Ac-EO caused an interesting dose-dependent reduction in the number of eggs of S. mansoni. Precocene I (74.30%) and (E)-caryophyllene (14.23%) were identified as the two major constituents of Ac-EO. These compounds were tested individually and were found to be much less effective than Ac-EO and PZQ. A mixture of the two major compounds in a ratio similar to that found in the Ac-EO was also less effective than Ac-EO, thus revealing that there are no synergistic effects between these components. These results suggest that the essential oil of A. conyzoides is very promising for the development of new schistosomicidal agents.
Keywords: Schistosoma; essential oil; Ageratum conyzoides Schistosoma; essential oil; Ageratum conyzoides

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

De Melo, N.I.; Magalhaes, L.G.; De Carvalho, C.E.; Wakabayashi, K.A.L.; De P. Aguiar, G.; Ramos, R.C.; Mantovani, A.L.L.; Turatti, I.C.C.; Rodrigues, V.; Groppo, M.; Cunha, W.R.; Veneziani, R.C.S.; Crotti, A.E.M. Schistosomicidal Activity of the Essential Oil of Ageratum conyzoides L. (Asteraceae) against Adult Schistosoma mansoni Worms. Molecules 2011, 16, 762-773.

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