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Transition Metal Catalyzed Synthesis of Aryl Sulfides
Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, OH 43210, USA
* Author to whom correspondence should be addressed.
Received: 17 December 2010; in revised form: 10 January 2011 / Accepted: 14 January 2011 / Published: 17 January 2011
Abstract: The presence of aryl sulfides in biologically active compounds has resulted in the development of new methods to form carbon-sulfur bonds. The synthesis of aryl sulfides via metal catalysis has significantly increased in recent years. Historically, thiolates and sulfides have been thought to plague catalyst activity in the presence of transition metals. Indeed, strong coordination of thiolates and thioethers to transition metals can often hinder catalytic activity; however, various catalysts are able to withstand catalyst deactivation and form aryl carbon-sulfur bonds in high-yielding transformations. This review discusses the metal-catalyzed arylation of thiols and the use of disulfides as metal-thiolate precursors for the formation of C-S bonds.
Keywords: C-S bond formation; biaryl sulfides; arylation of thiols
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Eichman, C.C.; Stambuli, J.P. Transition Metal Catalyzed Synthesis of Aryl Sulfides. Molecules 2011, 16, 590-608.
Eichman CC, Stambuli JP. Transition Metal Catalyzed Synthesis of Aryl Sulfides. Molecules. 2011; 16(1):590-608.
Eichman, Chad C.; Stambuli, James P. 2011. "Transition Metal Catalyzed Synthesis of Aryl Sulfides." Molecules 16, no. 1: 590-608.