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Molecules 2011, 16(1), 590-608; doi:10.3390/molecules16010590

Transition Metal Catalyzed Synthesis of Aryl Sulfides

Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, OH 43210, USA
Author to whom correspondence should be addressed.
Received: 17 December 2010 / Revised: 10 January 2011 / Accepted: 14 January 2011 / Published: 17 January 2011
(This article belongs to the Special Issue Homogeneous Catalysis)
Download PDF [238 KB, uploaded 18 June 2014]


The presence of aryl sulfides in biologically active compounds has resulted in the development of new methods to form carbon-sulfur bonds. The synthesis of aryl sulfides via metal catalysis has significantly increased in recent years. Historically, thiolates and sulfides have been thought to plague catalyst activity in the presence of transition metals. Indeed, strong coordination of thiolates and thioethers to transition metals can often hinder catalytic activity; however, various catalysts are able to withstand catalyst deactivation and form aryl carbon-sulfur bonds in high-yielding transformations. This review discusses the metal-catalyzed arylation of thiols and the use of disulfides as metal-thiolate precursors for the formation of C-S bonds.
Keywords: C-S bond formation; biaryl sulfides; arylation of thiols C-S bond formation; biaryl sulfides; arylation of thiols
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Eichman, C.C.; Stambuli, J.P. Transition Metal Catalyzed Synthesis of Aryl Sulfides. Molecules 2011, 16, 590-608.

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