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Phytochemical and Cytotoxic Investigations of Alpinia mutica Rhizomes
Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
Centre for Foundation Studies in Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
* Author to whom correspondence should be addressed.
Received: 2 December 2010; in revised form: 31 December 2010 / Accepted: 7 January 2011 / Published: 14 January 2011
Abstract: The methanol and fractionated extracts (hexane, ethyl acetate and water) of Alpinia mutica (Zingiberaceae) rhizomes were investigated for their cytotoxic effect against six human carcinoma cell lines, namely KB, MCF7, A549, Caski, HCT116, HT29 and non-human fibroblast cell line (MRC 5) using an in vitro cytotoxicity assay. The ethyl acetate extract possessed high inhibitory effect against KB, MCF7 and Caski cells (IC50 values of 9.4, 19.7 and 19.8 µg/mL, respectively). Flavokawin B (1), 5,6-dehydrokawain (2), pinostrobin chalcone (3) and alpinetin (4), isolated from the active ethyl acetate extract were also evaluated for their cytotoxic activity. Of these, pinostrobin chalcone (3) and alpinetin (4) were isolated from this plant for the first time. Pinostrobin chalcone (3) displayed very remarkable cytotoxic activity against the tested human cancer cells, such as KB, MCF7 and Caski cells (IC50 values of 6.2, 7.3 and 7.7 µg/mL, respectively). This is the first report of the cytotoxic activity of Alpinia mutica.
Keywords: Alpinia mutica; cytotoxic activity; cancer cell line
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MDPI and ACS Style
Malek, S.N.A.; Phang, C.W.; Ibrahim, H.; Abdul Wahab, N.; Sim, K.S. Phytochemical and Cytotoxic Investigations of Alpinia mutica Rhizomes. Molecules 2011, 16, 583-589.
Malek SNA, Phang CW, Ibrahim H, Abdul Wahab N, Sim KS. Phytochemical and Cytotoxic Investigations of Alpinia mutica Rhizomes. Molecules. 2011; 16(1):583-589.
Malek, Sri Nurestri Abdul; Phang, Chung Weng; Ibrahim, Halijah; Abdul Wahab, Norhanom; Sim, Kae Shin. 2011. "Phytochemical and Cytotoxic Investigations of Alpinia mutica Rhizomes." Molecules 16, no. 1: 583-589.