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Molecules 2011, 16(1), 583-589; doi:10.3390/molecules16010583
Article

Phytochemical and Cytotoxic Investigations of Alpinia mutica Rhizomes

1,* , 1, 1, 2 and 1
1 Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia 2 Centre for Foundation Studies in Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
* Author to whom correspondence should be addressed.
Received: 2 December 2010 / Revised: 31 December 2010 / Accepted: 7 January 2011 / Published: 14 January 2011
(This article belongs to the Section Metabolites)
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Abstract

The methanol and fractionated extracts (hexane, ethyl acetate and water) of Alpinia mutica (Zingiberaceae) rhizomes were investigated for their cytotoxic effect against six human carcinoma cell lines, namely KB, MCF7, A549, Caski, HCT116, HT29 and non-human fibroblast cell line (MRC 5) using an in vitro cytotoxicity assay. The ethyl acetate extract possessed high inhibitory effect against KB, MCF7 and Caski cells (IC50 values of 9.4, 19.7 and 19.8 µg/mL, respectively). Flavokawin B (1), 5,6-dehydrokawain (2), pinostrobin chalcone (3) and alpinetin (4), isolated from the active ethyl acetate extract were also evaluated for their cytotoxic activity. Of these, pinostrobin chalcone (3) and alpinetin (4) were isolated from this plant for the first time. Pinostrobin chalcone (3) displayed very remarkable cytotoxic activity against the tested human cancer cells, such as KB, MCF7 and Caski cells (IC50 values of 6.2, 7.3 and 7.7 µg/mL, respectively). This is the first report of the cytotoxic activity of Alpinia mutica.
Keywords: Alpinia mutica; cytotoxic activity; cancer cell line Alpinia mutica; cytotoxic activity; cancer cell line
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Malek, S.N.A.; Phang, C.W.; Ibrahim, H.; Abdul Wahab, N.; Sim, K.S. Phytochemical and Cytotoxic Investigations of Alpinia mutica Rhizomes. Molecules 2011, 16, 583-589.

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