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Antioxidant Activities of Celery and Parsley Juices in Rats Treated with Doxorubicin
Institute for Child and Youth Health Care of Vojvodina, Department of Hematology/Oncology, Novi Sad, Serbia
Department of Chemistry, Faculty of Science, University of Novi Sad, Serbia
University of Central Europe in Skalica, Slovakia
The Health Center, 21000 Novi Sad, Serbia
* Author to whom correspondence should be addressed.
Received: 23 July 2010; in revised form: 27 August 2010 / Accepted: 2 September 2010 / Published: 3 September 2010
Abstract: We have examined the influence of diluted pure celery and parsley leaf and root juices and their combinations with doxorubicin on the antioxidant status [as measured by the content of reduced glutathione (GSH) and ferric reducing antioxidant power (FRAP)] in liver homogenate and hemolysate and on the contents of cytochrome P450 in liver homogenate. It was found that doxorubicin significantly decreased the content of reduced glutathione and the total antioxidative status (FRAP) in liver homogenate and hemolysate, while celery and parsley juices alone and in combination with doxorubicin had different actions. Doxorubicin and celery juice had no effect on content of cytochrome P450. However, in combination with doxorubicin, parsley root juice significant increased, and parsley leaves juice decreased the cytochrome P450 content (compared to doxorubicin treated animals). Only parsley root juice significantly increased the content of cytochrome P450.
Keywords: celery and parsley juices; doxorubicin; reduced glutathione; FRAP; Cyt P450
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Kolarovic, J.; Popovic, M.; Zlinská, J.; Trivic, S.; Vojnovic, M. Antioxidant Activities of Celery and Parsley Juices in Rats Treated with Doxorubicin. Molecules 2010, 15, 6193-6204.
Kolarovic J, Popovic M, Zlinská J, Trivic S, Vojnovic M. Antioxidant Activities of Celery and Parsley Juices in Rats Treated with Doxorubicin. Molecules. 2010; 15(9):6193-6204.
Kolarovic, Jovanka; Popovic, Mira; Zlinská, Janka; Trivic, Svetlana; Vojnovic, Matilda. 2010. "Antioxidant Activities of Celery and Parsley Juices in Rats Treated with Doxorubicin." Molecules 15, no. 9: 6193-6204.