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Molecules 2010, 15(9), 6193-6204; doi:10.3390/molecules15096193
Article

Antioxidant Activities of Celery and Parsley Juices in Rats Treated with Doxorubicin

1
, 2,* , 3, 2 and 4
1 Institute for Child and Youth Health Care of Vojvodina, Department of Hematology/Oncology, Novi Sad, Serbia 2 Department of Chemistry, Faculty of Science, University of Novi Sad, Serbia 3 University of Central Europe in Skalica, Slovakia 4 The Health Center, 21000 Novi Sad, Serbia
* Author to whom correspondence should be addressed.
Received: 23 July 2010 / Revised: 27 August 2010 / Accepted: 2 September 2010 / Published: 3 September 2010
(This article belongs to the Section Medicinal Chemistry)
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Abstract

We have examined the influence of diluted pure celery and parsley leaf and root juices and their combinations with doxorubicin on the antioxidant status [as measured by the content of reduced glutathione (GSH) and ferric reducing antioxidant power (FRAP)] in liver homogenate and hemolysate and on the contents of cytochrome P450 in liver homogenate. It was found that doxorubicin significantly decreased the content of reduced glutathione and the total antioxidative status (FRAP) in liver homogenate and hemolysate, while celery and parsley juices alone and in combination with doxorubicin had different actions. Doxorubicin and celery juice had no effect on content of cytochrome P450. However, in combination with doxorubicin, parsley root juice significant increased, and parsley leaves juice decreased the cytochrome P450 content (compared to doxorubicin treated animals). Only parsley root juice significantly increased the content of cytochrome P450.
Keywords: celery and parsley juices; doxorubicin; reduced glutathione; FRAP; Cyt P450 celery and parsley juices; doxorubicin; reduced glutathione; FRAP; Cyt P450
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Kolarovic, J.; Popovic, M.; Zlinská, J.; Trivic, S.; Vojnovic, M. Antioxidant Activities of Celery and Parsley Juices in Rats Treated with Doxorubicin. Molecules 2010, 15, 6193-6204.

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