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Molecules 2010, 15(8), 5807-5817; doi:10.3390/molecules15085807
Article

Antimicrobial and Antioxidant Activities of the Root Bark Essential Oil of Periploca sepium and Its Main Component 2-Hydroxy-4-methoxybenzaldehyde

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Received: 5 August 2010; in revised form: 16 August 2010 / Accepted: 23 August 2010 / Published: 24 August 2010
(This article belongs to the Special Issue Phenolics and Polyphenolics)
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Abstract: The root bark essential oil of Periploca sepium Bunge (Asclepiadaceae/ Apocynaceae) obtained by hydrodistillation was investigated by GC and GC-MS. 2-Hydroxy-4-methoxybenzaldehyde was found to be the main component (78.8% of the total) among 17 identified compounds. 2-Hydroxy-4-methoxybenzaldehyde was separated and purified by preparative thin layer chromatography, and was further identified by means of physicochemical and spectrometric analysis. Both the essential oil and 2-hydroxy-4-methoxybenzaldehyde exhibited antimicrobial activities on all test bacteria and fungi, with MBC/MFC values ranging from 125 μg/mL to 300 μg/mL, MIC values from 80 μg/mL to 300 μg/mL, and IC50 values from 63.29 μg/mL to 167.30 μg/mL. They also showed moderate antioxidant activity in the DPPH free radical scavenging, β-carotene bleaching and ferrozine-ferrous ions assays. The results indicated that the major portion of these antimicrobial and antioxidant activities was due to the presence of 2-hydroxy-4-methoxy-benzaldehyde in the oil, which could potentially be developed as an antimicrobial and antioxidant agent in the future.
Keywords: Asclepiadaceae; Apocynaceae; Periploca sepium; essential oil; 2-hydroxy-4-methoxybenzaldehyde; antimicrobial activity; antioxidant activity Asclepiadaceae; Apocynaceae; Periploca sepium; essential oil; 2-hydroxy-4-methoxybenzaldehyde; antimicrobial activity; antioxidant activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Wang, J.; Liu, H.; Zhao, J.; Gao, H.; Zhou, L.; Liu, Z.; Chen, Y.; Sui, P. Antimicrobial and Antioxidant Activities of the Root Bark Essential Oil of Periploca sepium and Its Main Component 2-Hydroxy-4-methoxybenzaldehyde. Molecules 2010, 15, 5807-5817.

AMA Style

Wang J, Liu H, Zhao J, Gao H, Zhou L, Liu Z, Chen Y, Sui P. Antimicrobial and Antioxidant Activities of the Root Bark Essential Oil of Periploca sepium and Its Main Component 2-Hydroxy-4-methoxybenzaldehyde. Molecules. 2010; 15(8):5807-5817.

Chicago/Turabian Style

Wang, Jihua; Liu, Hao; Zhao, Jianglin; Gao, Haifeng; Zhou, Ligang; Liu, Zhilong; Chen, Yuanquan; Sui, Peng. 2010. "Antimicrobial and Antioxidant Activities of the Root Bark Essential Oil of Periploca sepium and Its Main Component 2-Hydroxy-4-methoxybenzaldehyde." Molecules 15, no. 8: 5807-5817.


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