Next Article in Journal
The Application of Ribozymes and DNAzymes in Muscle and Brain
Next Article in Special Issue
Evaluation of Antioxidant Potential of Lavandula x intermedia Emeric ex Loisel. 'Budrovka': A Comparative Study with L. angustifolia Mill.
Previous Article in Journal
Molecular Evolution of Functional Nucleic Acids with Chemical Modifications
Previous Article in Special Issue
Synthesis of β-Maltooligosaccharides of Glycitein and Daidzein and their Anti-Oxidant and Anti-Allergic Activities
Molecules 2010, 15(8), 5445-5459; doi:10.3390/molecules15085445

Antioxidant Activity of Butyl- and Phenylstannoxanes Derivedfrom 2-, 3- and 4-Pyridinecarboxylic Acids

1, 2, 3, 1, 1, 4 and 1,*
1 Facultad de Ciencias Químicas, Universidad de Colima, kilómetro 9 carretera Colima, Coquimatlán, Col. Mexico. C.P. 28400, Mexico 2 Centro Universitario de Ciencias Exactas e Ingenierías, Universidad de Guadalajara, Laboratorio de Inmunofarmacología, Blvd. Marcelino García Barragán No. 1421, esq. Calzada Olímpica, C.P. 4430, Guadalajara, Jal., Mexico 3 Departamento de Química, Centro de Investigación y de Estudios Avanzados-IPN. Apartado, Postal 14-740. Mexico 07000, D. F., Mexico 4 Unidad Académica de Agricultura, Universidad Autónoma de Nayarit, Cd. de la Cultura "Amado Nervo", Boulevard Tepic-Xalisco s/n. C.P. 63190. Tepic, Nayarit, Mexico
* Author to whom correspondence should be addressed.
Received: 7 May 2010 / Revised: 31 May 2010 / Accepted: 15 July 2010 / Published: 9 August 2010
(This article belongs to the Special Issue Antioxidants)
Download PDF [220 KB, uploaded 18 June 2014]


In vitro antioxidant activity for 12 stannoxanes derived from Ph3SnCl (compounds 1-3), Ph2SnCl2 (compounds 4-6), Bu3SnCl (compounds 7-9), and Bu2SnCl2 (compounds 10-12), was assayed qualitatively by the chromatographic profile with 1,1-diphenyl-2-picrylhydrazil (DPPH) method and by two quantitative methods: the DPPH radical scavenging activity and Ferric-Reducing Antioxidant Power (FRAP) assays. The results were compared with those obtained with the starting materials 2-pyridine- carboxylic acid (I), 3-pyridinecarboxylic acid (II) and 4-pyridinecarboxylic acid (III), as well as with standard compounds, such as vitamin C and vitamin E, respectively. The in vitro antiradical activity with DPPH of diphenyltin derivative 5 showed a very similar behavior to vitamin C at a 20 µg/mL concentration, whereas according to the FRAP method, compound 8 was better. This difference is due to the mechanism of the antioxidant process. The Structure-Activity Relationships (SAR) for both methods is also reported.
Keywords: antioxidant activity; pyridinecarboxylate; organotin; DPPH; ferric-reducing antioxidant activity; pyridinecarboxylate; organotin; DPPH; ferric-reducing
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Corona-Bustamante, A.; Viveros-Paredes, J.M.; Flores-Parra, A.; Peraza-Campos, A.L.; Martínez-Martínez, F.J.; Sumaya-Martínez, M.T.; Ramos-Organillo, Á. Antioxidant Activity of Butyl- and Phenylstannoxanes Derivedfrom 2-, 3- and 4-Pyridinecarboxylic Acids. Molecules 2010, 15, 5445-5459.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert