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Molecules 2010, 15(8), 5445-5459; doi:10.3390/molecules15085445
Article

Antioxidant Activity of Butyl- and Phenylstannoxanes Derivedfrom 2-, 3- and 4-Pyridinecarboxylic Acids

1, 2, 3, 1, 1, 4 and 1,*
Received: 7 May 2010; in revised form: 31 May 2010 / Accepted: 15 July 2010 / Published: 9 August 2010
(This article belongs to the Special Issue Antioxidants)
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Abstract: In vitro antioxidant activity for 12 stannoxanes derived from Ph3SnCl (compounds 1-3), Ph2SnCl2 (compounds 4-6), Bu3SnCl (compounds 7-9), and Bu2SnCl2 (compounds 10-12), was assayed qualitatively by the chromatographic profile with 1,1-diphenyl-2-picrylhydrazil (DPPH) method and by two quantitative methods: the DPPH radical scavenging activity and Ferric-Reducing Antioxidant Power (FRAP) assays. The results were compared with those obtained with the starting materials 2-pyridine- carboxylic acid (I), 3-pyridinecarboxylic acid (II) and 4-pyridinecarboxylic acid (III), as well as with standard compounds, such as vitamin C and vitamin E, respectively. The in vitro antiradical activity with DPPH of diphenyltin derivative 5 showed a very similar behavior to vitamin C at a 20 µg/mL concentration, whereas according to the FRAP method, compound 8 was better. This difference is due to the mechanism of the antioxidant process. The Structure-Activity Relationships (SAR) for both methods is also reported.
Keywords: antioxidant activity; pyridinecarboxylate; organotin; DPPH; ferric-reducing antioxidant activity; pyridinecarboxylate; organotin; DPPH; ferric-reducing
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Corona-Bustamante, A.; Viveros-Paredes, J.M.; Flores-Parra, A.; Peraza-Campos, A.L.; Martínez-Martínez, F.J.; Sumaya-Martínez, M.T.; Ramos-Organillo, Á. Antioxidant Activity of Butyl- and Phenylstannoxanes Derivedfrom 2-, 3- and 4-Pyridinecarboxylic Acids. Molecules 2010, 15, 5445-5459.

AMA Style

Corona-Bustamante A, Viveros-Paredes JM, Flores-Parra A, Peraza-Campos AL, Martínez-Martínez FJ, Sumaya-Martínez MT, Ramos-Organillo Á. Antioxidant Activity of Butyl- and Phenylstannoxanes Derivedfrom 2-, 3- and 4-Pyridinecarboxylic Acids. Molecules. 2010; 15(8):5445-5459.

Chicago/Turabian Style

Corona-Bustamante, Alicia; Viveros-Paredes, Juan Manuel; Flores-Parra, Angelina; Peraza-Campos, Ana Lilia; Martínez-Martínez, Francisco J.; Sumaya-Martínez, María Teresa; Ramos-Organillo, Ángel. 2010. "Antioxidant Activity of Butyl- and Phenylstannoxanes Derivedfrom 2-, 3- and 4-Pyridinecarboxylic Acids." Molecules 15, no. 8: 5445-5459.


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