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Compounds from Viburnum sargentii Koehne and Evaluation of Their Cytotoxic Effects on Human Cancer Cell Lines
Department of Forest Products and Biotechnology, College of Forest Sciences, Kookmin University, Seoul, 136-702, Korea
* Author to whom correspondence should be addressed.
Received: 2 April 2010; in revised form: 14 May 2010 / Accepted: 9 June 2010 / Published: 25 June 2010
Abstract: Compounds were isolated from a methanol extract of the dried stem barks of Viburnum sargentii Koehne. The structures of the compounds, namely 9'-O-methylvibsanol (3), furcatoside A (4) and lareciresinol (5) were elucidated by analysis of spectroscopic data and comparison with values for previously known analogues. In addition, (+)-catechin (1), (+)-epicatechin (2) were also isolated. This work also examined the cytotoxic effects of three compounds 3-5 (25-100 μM) in MCF-7 and A549 cells after 24, 48 and 72 h of exposure. Our results showed that 9'-O-methylvibsanol (3) exhibited strong concentration-dependent anticancer effects according to the MTT assay and produced morphological changes consistent with apoptosis, as confirmed by Ho3342 staining analysis revealed that more apoptotic cells were observed after 9'-Omethylvibsanol (3) treatment.
Keywords: Viburnum sargentii; Caprifoliaceae; furcatoside A; 9'-O-methylvibsanol; lareciresinol; Cancer cells; antitumor activity
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Bae, K.-E.; Chong, H.-S.; Kim, D.-S.; Choi, Y.-W.; Kim, Y.-S.; Kim, Y.-K. Compounds from Viburnum sargentii Koehne and Evaluation of Their Cytotoxic Effects on Human Cancer Cell Lines. Molecules 2010, 15, 4599-4609.
Bae K-E, Chong H-S, Kim D-S, Choi Y-W, Kim Y-S, Kim Y-K. Compounds from Viburnum sargentii Koehne and Evaluation of Their Cytotoxic Effects on Human Cancer Cell Lines. Molecules. 2010; 15(7):4599-4609.
Bae, Ki-Eun; Chong, Han-Soo; Kim, Dong-Sup; Choi, Young-Woong; Kim, Young-Sook; Kim, Young-Kyoon. 2010. "Compounds from Viburnum sargentii Koehne and Evaluation of Their Cytotoxic Effects on Human Cancer Cell Lines." Molecules 15, no. 7: 4599-4609.