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Molecules 2010, 15(7), 4599-4609; doi:10.3390/molecules15074599

Compounds from Viburnum sargentii Koehne and Evaluation of Their Cytotoxic Effects on Human Cancer Cell Lines

Department of Forest Products and Biotechnology, College of Forest Sciences, Kookmin University, Seoul, 136-702, Korea
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Received: 2 April 2010 / Revised: 14 May 2010 / Accepted: 9 June 2010 / Published: 25 June 2010
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Abstract

Compounds were isolated from a methanol extract of the dried stem barks of Viburnum sargentii Koehne. The structures of the compounds, namely 9'-O-methylvibsanol (3), furcatoside A (4) and lareciresinol (5) were elucidated by analysis of spectroscopic data and comparison with values for previously known analogues. In addition, (+)-catechin (1), (+)-epicatechin (2) were also isolated. This work also examined the cytotoxic effects of three compounds 3-5 (25-100 μM) in MCF-7 and A549 cells after 24, 48 and 72 h of exposure. Our results showed that 9'-O-methylvibsanol (3) exhibited strong concentration-dependent anticancer effects according to the MTT assay and produced morphological changes consistent with apoptosis, as confirmed by Ho3342 staining analysis revealed that more apoptotic cells were observed after 9'-Omethylvibsanol (3) treatment.
Keywords: Viburnum sargentii; Caprifoliaceae; furcatoside A; 9'-O-methylvibsanol; lareciresinol; Cancer cells; antitumor activity Viburnum sargentii; Caprifoliaceae; furcatoside A; 9'-O-methylvibsanol; lareciresinol; Cancer cells; antitumor activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Bae, K.-E.; Chong, H.-S.; Kim, D.-S.; Choi, Y.-W.; Kim, Y.-S.; Kim, Y.-K. Compounds from Viburnum sargentii Koehne and Evaluation of Their Cytotoxic Effects on Human Cancer Cell Lines. Molecules 2010, 15, 4599-4609.

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