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Molecules 2010, 15(7), 4589-4598; doi:10.3390/molecules15074589

New Steroidal Glycosides Isolated as CD40L Inhibitors of Activated Platelets

2,* , 1
1 Institute for Biomedical Research, Xiamen University, Xiamen 361005, China 2 Department of Cardiology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, China 3 Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, China 4 Clinical Medicine & Pharmacy College, China Medical University, Shenyang 110001, China
* Authors to whom correspondence should be addressed.
Received: 24 April 2010 / Revised: 25 May 2010 / Accepted: 7 June 2010 / Published: 25 June 2010
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Three new compounds were isolated from the dried bulbs of Allium macrostemon Bunge. Their structures were elucidated from their spectral data as (25R)-26-O-β-D-glucopyranosyl-5α-furostane-3β,12β,22,26-tetraol-3-O-β-D-glucopyranos-yl (1→2) [β-D-glucopyranosyl (1→3)]-β-D-glucopyranosyl (1→4)-β-D-galactopyranoside (1), (25R)-26-O-β-D-glucopyranosyl-5α-furostane-3β,12α,22,26-tetraol-3-O-β-D-glucopyranosyl (1→2) [β-D-glucopyranosyl (1→3)]-β-D-glucopyranosyl (1→4)-β-D-galacto- pyranoside (2) and (25R)-26-O-β-D-glucopyranosyl-5β-furostane-3β,12α,22,26-tetraol-3-O-β-D-glucopyranosyl (1→2)-β-D-galactopyranoside (3), respectively. The inhibition effect of all compounds on CD40 ligand (CD40L) expression on the membrane of activated platelets stimulated by ADP was tested. Compounds 1 and 2 exhibited significant inhibitory activities in a dose dependent manner (P < 0.05), suggesting their potential application as CD40L inhibitors.
Keywords: steroidal glycosides; Allium macrostemon Bunge; CD40L inhibitors steroidal glycosides; Allium macrostemon Bunge; CD40L inhibitors
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Chen, H.; Ou, W.; Wang, G.; Wang, N.; Zhang, L.; Yao, X. New Steroidal Glycosides Isolated as CD40L Inhibitors of Activated Platelets. Molecules 2010, 15, 4589-4598.

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