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New Steroidal Glycosides Isolated as CD40L Inhibitors of Activated Platelets
Institute for Biomedical Research, Xiamen University, Xiamen 361005, China
Department of Cardiology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou 510260, China
Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, China
Clinical Medicine & Pharmacy College, China Medical University, Shenyang 110001, China
* Authors to whom correspondence should be addressed.
Received: 24 April 2010; in revised form: 25 May 2010 / Accepted: 7 June 2010 / Published: 25 June 2010
Abstract: Three new compounds were isolated from the dried bulbs of Allium macrostemon Bunge. Their structures were elucidated from their spectral data as (25R)-26-O-β-D-glucopyranosyl-5α-furostane-3β,12β,22,26-tetraol-3-O-β-D-glucopyranos-yl (1→2) [β-D-glucopyranosyl (1→3)]-β-D-glucopyranosyl (1→4)-β-D-galactopyranoside (1), (25R)-26-O-β-D-glucopyranosyl-5α-furostane-3β,12α,22,26-tetraol-3-O-β-D-glucopyranosyl (1→2) [β-D-glucopyranosyl (1→3)]-β-D-glucopyranosyl (1→4)-β-D-galacto- pyranoside (2) and (25R)-26-O-β-D-glucopyranosyl-5β-furostane-3β,12α,22,26-tetraol-3-O-β-D-glucopyranosyl (1→2)-β-D-galactopyranoside (3), respectively. The inhibition effect of all compounds on CD40 ligand (CD40L) expression on the membrane of activated platelets stimulated by ADP was tested. Compounds 1 and 2 exhibited significant inhibitory activities in a dose dependent manner (P < 0.05), suggesting their potential application as CD40L inhibitors.
Keywords: steroidal glycosides; Allium macrostemon Bunge; CD40L inhibitors
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Chen, H.; Ou, W.; Wang, G.; Wang, N.; Zhang, L.; Yao, X. New Steroidal Glycosides Isolated as CD40L Inhibitors of Activated Platelets. Molecules 2010, 15, 4589-4598.
Chen H, Ou W, Wang G, Wang N, Zhang L, Yao X. New Steroidal Glycosides Isolated as CD40L Inhibitors of Activated Platelets. Molecules. 2010; 15(7):4589-4598.
Chen, Haifeng; Ou, Wenchao; Wang, Guanghui; Wang, Naili; Zhang, Linnan; Yao, Xinsheng. 2010. "New Steroidal Glycosides Isolated as CD40L Inhibitors of Activated Platelets." Molecules 15, no. 7: 4589-4598.