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Molecules 2010, 15(7), 4589-4598; doi:10.3390/molecules15074589
Article

New Steroidal Glycosides Isolated as CD40L Inhibitors of Activated Platelets

1
, 2,* , 1
, 3
, 4
 and 1,3,*
Received: 24 April 2010; in revised form: 25 May 2010 / Accepted: 7 June 2010 / Published: 25 June 2010
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Abstract: Three new compounds were isolated from the dried bulbs of Allium macrostemon Bunge. Their structures were elucidated from their spectral data as (25R)-26-O-β-D-glucopyranosyl-5α-furostane-3β,12β,22,26-tetraol-3-O-β-D-glucopyranos-yl (1→2) [β-D-glucopyranosyl (1→3)]-β-D-glucopyranosyl (1→4)-β-D-galactopyranoside (1), (25R)-26-O-β-D-glucopyranosyl-5α-furostane-3β,12α,22,26-tetraol-3-O-β-D-glucopyranosyl (1→2) [β-D-glucopyranosyl (1→3)]-β-D-glucopyranosyl (1→4)-β-D-galacto- pyranoside (2) and (25R)-26-O-β-D-glucopyranosyl-5β-furostane-3β,12α,22,26-tetraol-3-O-β-D-glucopyranosyl (1→2)-β-D-galactopyranoside (3), respectively. The inhibition effect of all compounds on CD40 ligand (CD40L) expression on the membrane of activated platelets stimulated by ADP was tested. Compounds 1 and 2 exhibited significant inhibitory activities in a dose dependent manner (P < 0.05), suggesting their potential application as CD40L inhibitors.
Keywords: steroidal glycosides; Allium macrostemon Bunge; CD40L inhibitors steroidal glycosides; Allium macrostemon Bunge; CD40L inhibitors
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Chen, H.; Ou, W.; Wang, G.; Wang, N.; Zhang, L.; Yao, X. New Steroidal Glycosides Isolated as CD40L Inhibitors of Activated Platelets. Molecules 2010, 15, 4589-4598.

AMA Style

Chen H, Ou W, Wang G, Wang N, Zhang L, Yao X. New Steroidal Glycosides Isolated as CD40L Inhibitors of Activated Platelets. Molecules. 2010; 15(7):4589-4598.

Chicago/Turabian Style

Chen, Haifeng; Ou, Wenchao; Wang, Guanghui; Wang, Naili; Zhang, Linnan; Yao, Xinsheng. 2010. "New Steroidal Glycosides Isolated as CD40L Inhibitors of Activated Platelets." Molecules 15, no. 7: 4589-4598.



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