Abstract: Three new compounds were isolated from the dried bulbs of Allium macrostemon Bunge. Their structures were elucidated from their spectral data as (25R)-26-O-β-D-glucopyranosyl-5α-furostane-3β,12β,22,26-tetraol-3-O-β-D-glucopyranos-yl (1→2) [β-D-glucopyranosyl (1→3)]-β-D-glucopyranosyl (1→4)-β-D-galactopyranoside (1), (25R)-26-O-β-D-glucopyranosyl-5α-furostane-3β,12α,22,26-tetraol-3-O-β-D-glucopyranosyl (1→2) [β-D-glucopyranosyl (1→3)]-β-D-glucopyranosyl (1→4)-β-D-galacto- pyranoside (2) and (25R)-26-O-β-D-glucopyranosyl-5β-furostane-3β,12α,22,26-tetraol-3-O-β-D-glucopyranosyl (1→2)-β-D-galactopyranoside (3), respectively. The inhibition effect of all compounds on CD40 ligand (CD40L) expression on the membrane of activated platelets stimulated by ADP was tested. Compounds 1 and 2 exhibited significant inhibitory activities in a dose dependent manner (P < 0.05), suggesting their potential application as CD40L inhibitors.
Keywords: steroidal glycosides; Allium macrostemon Bunge; CD40L inhibitors
This is an open access article distributed under the
Creative Commons Attribution License which permits unrestricted use, distribution,
and reproduction in any medium, provided the original work is properly cited.
Export to BibTeX
MDPI and ACS Style
Chen, H.; Ou, W.; Wang, G.; Wang, N.; Zhang, L.; Yao, X. New Steroidal Glycosides Isolated as CD40L Inhibitors of Activated Platelets. Molecules 2010, 15, 4589-4598.
Chen H, Ou W, Wang G, Wang N, Zhang L, Yao X. New Steroidal Glycosides Isolated as CD40L Inhibitors of Activated Platelets. Molecules. 2010; 15(7):4589-4598.
Chen, Haifeng; Ou, Wenchao; Wang, Guanghui; Wang, Naili; Zhang, Linnan; Yao, Xinsheng. 2010. "New Steroidal Glycosides Isolated as CD40L Inhibitors of Activated Platelets." Molecules 15, no. 7: 4589-4598.