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Molecules 2010, 15(5), 3731-3743; doi:10.3390/molecules15053731
Article

Microwave Synthesis, Basic Spectral and Biological Evaluation of Some Copper (II) Mesoporphyrinic Complexes

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Received: 27 April 2010 / Revised: 19 May 2010 / Accepted: 24 May 2010 / Published: 25 May 2010
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Abstract

Cu(II) complexes with asymmetrical and symmetrical porphyrinic ligands were synthesized with superior yields using microwave irradiation. The paper presents the synthesis of 5-(3-hydroxyphenyl)-10,15,20-tris-(4-carboxymethylphenyl)-21,23-Cu(II)-porphine in comparison to its symmetrical complex 5,10,15,20-meso-tetrakis-(4-carboxy-methylphenyl)-21,23-Cu(II) porphine. The two compounds were characterized by FT-IR, UV–Vis and EPR spectroscopy, which fully confirmed the structures. The spectral molecular absorption properties of the porphyrinic complexes were studied in organic solvents (methanol, ethanol, iso-propanol, dimethyl sulfoxide, dimethylformamide and methylene chloride), and the influence of the solvent polarity on the absorbance maxima is described. In order to establish their future potential in biomedical applications preliminary toxicological studies consisting of viability and proliferation of standard tumor cell lines (MCF7 and B16) testing was performed. The obtained results indicate a low toxicity for both compounds and further recommends them for testing in light activation protocols.
Keywords: copper (II) mesoporphyrinic complexes; FT-IR spectroscopy; solvatochromy; cytotoxicity copper (II) mesoporphyrinic complexes; FT-IR spectroscopy; solvatochromy; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Boscencu, R.; Ilie, M.; Socoteanu, R.; Oliveira, A.S.; Constantin, C.; Neagu, M.; Manda, G.; Ferreira, L.F.V. Microwave Synthesis, Basic Spectral and Biological Evaluation of Some Copper (II) Mesoporphyrinic Complexes. Molecules 2010, 15, 3731-3743.

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