Enantioselectivity Induced by Oxazaborolidine Supported on Mesoporous Silica or by Its Analog in Homogeneous Phase

doi:10.3390/molecules15053643

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Molecules 2010, 15(5), 3643-3660; doi:10.3390/molecules15053643

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Enantioselectivity Induced by Oxazaborolidine Supported on Mesoporous Silica or by Its Analog in Homogeneous Phase

Jeremy H. Yune, Françoise Quignard and Karine Molvinger*

Institut Charles Gerhardt Montpellier, UMR 5253 CNRS/ENSCM/UM2/UM1, Matériaux Avancés pour la Catalyse et la Santé, « MACS » - 8, rue de l’Ecole Normale, 34296 Montpellier cedex 5, France

* Author to whom correspondence should be addressed.

Received: 19 April 2010; in revised form: 6 May 2010 / Accepted: 12 May 2010 / Published: 18 May 2010

(This article belongs to the Special Issue Heterogeneous Catalysis)

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Abstract: The impact of immobilization of oxazaborolidines supported on silica via different substituents on the boron and nitrogen atoms is evaluated in the enantioselective reduction of acetophenone. The performances of the homogeneous analog oxazaborolidines and silica supported-ones are compared by varying different parameters. This article deals with the synthesis, characterization and catalytic evaluation of silica-supported oxazaborolidines, their recycling capabilities and regeneration limitations.

Keywords: oxazaborolidine; supported catalyst; mesoporous silica; asymmetric reduction of acetophenone

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MDPI and ACS Style

Yune, J.H.; Quignard, F.; Molvinger, K. Enantioselectivity Induced by Oxazaborolidine Supported on Mesoporous Silica or by Its Analog in Homogeneous Phase. Molecules 2010, 15, 3643-3660.

AMA Style

Yune JH, Quignard F, Molvinger K. Enantioselectivity Induced by Oxazaborolidine Supported on Mesoporous Silica or by Its Analog in Homogeneous Phase. Molecules. 2010; 15(5):3643-3660.

Chicago/Turabian Style

Yune, Jeremy H.; Quignard, Françoise; Molvinger, Karine. 2010. "Enantioselectivity Induced by Oxazaborolidine Supported on Mesoporous Silica or by Its Analog in Homogeneous Phase." Molecules 15, no. 5: 3643-3660.

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