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Molecules 2010, 15(5), 3634-3642; doi:10.3390/molecules15053634

Synthesis and Effect on Human HepG2 Cells of 1,2-bis- (2-Methylallyl)disulfane

1,* , 1
1 and 2
1 College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, China 2 Research Institute for Molecular Pharmacology and Therapeutics, Central South University, Changsha, Hunan 410083, China
* Author to whom correspondence should be addressed.
Received: 16 April 2010 / Revised: 11 May 2010 / Accepted: 12 May 2010 / Published: 18 May 2010
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1,2-bis(2-methylallyl)disulfane was synthesized from sodium sulfide and 3-chloro-2-methylpropylene. The structure of the target product was confirmed by GC-MS, 1H-NMR and elemental analysis. Cell viability assay, flow-cytometric analysis and protein expression results showed that 1,2-bis(2-methylallyl)disulfane could significantly inhibit the proliferation, and induce the apoptosis of human HepG2 cells.
Keywords: 1,2-bis(2-methylallyl)disulfane; identification; apoptosis 1,2-bis(2-methylallyl)disulfane; identification; apoptosis
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Ji, C.; Ren, F.; Dai, J.; Xu, M. Synthesis and Effect on Human HepG2 Cells of 1,2-bis- (2-Methylallyl)disulfane. Molecules 2010, 15, 3634-3642.

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