Synthesis and Effect on Human HepG2 Cells of 1,2-bis- (2-Methylallyl)disulfane

doi:10.3390/molecules15053634

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Molecules 2010, 15(5), 3634-3642; doi:10.3390/molecules15053634

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Synthesis and Effect on Human HepG2 Cells of 1,2-bis- (2-Methylallyl)disulfane

Chunxiao Ji^1,* , Fenglian Ren¹, Jun Dai¹ and Ming Xu²

¹ College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, China ² Research Institute for Molecular Pharmacology and Therapeutics, Central South University, Changsha, Hunan 410083, China

* Author to whom correspondence should be addressed.

Received: 16 April 2010; in revised form: 11 May 2010 / Accepted: 12 May 2010 / Published: 18 May 2010

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Abstract: 1,2-bis(2-methylallyl)disulfane was synthesized from sodium sulfide and 3-chloro-2-methylpropylene. The structure of the target product was confirmed by GC-MS, 1H-NMR and elemental analysis. Cell viability assay, flow-cytometric analysis and protein expression results showed that 1,2-bis(2-methylallyl)disulfane could significantly inhibit the proliferation, and induce the apoptosis of human HepG2 cells.

Keywords: 1,2-bis(2-methylallyl)disulfane; identification; apoptosis

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MDPI and ACS Style

Ji, C.; Ren, F.; Dai, J.; Xu, M. Synthesis and Effect on Human HepG2 Cells of 1,2-bis- (2-Methylallyl)disulfane. Molecules 2010, 15, 3634-3642.

AMA Style

Ji C, Ren F, Dai J, Xu M. Synthesis and Effect on Human HepG2 Cells of 1,2-bis- (2-Methylallyl)disulfane. Molecules. 2010; 15(5):3634-3642.

Chicago/Turabian Style

Ji, Chunxiao; Ren, Fenglian; Dai, Jun; Xu, Ming. 2010. "Synthesis and Effect on Human HepG2 Cells of 1,2-bis- (2-Methylallyl)disulfane." Molecules 15, no. 5: 3634-3642.

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