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Molecules 2010, 15(5), 3634-3642; doi:10.3390/molecules15053634
Article

Synthesis and Effect on Human HepG2 Cells of 1,2-bis- (2-Methylallyl)disulfane

1,* , 1
,
1 and 2
1 College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, China 2 Research Institute for Molecular Pharmacology and Therapeutics, Central South University, Changsha, Hunan 410083, China
* Author to whom correspondence should be addressed.
Received: 16 April 2010 / Revised: 11 May 2010 / Accepted: 12 May 2010 / Published: 18 May 2010
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Abstract

1,2-bis(2-methylallyl)disulfane was synthesized from sodium sulfide and 3-chloro-2-methylpropylene. The structure of the target product was confirmed by GC-MS, 1H-NMR and elemental analysis. Cell viability assay, flow-cytometric analysis and protein expression results showed that 1,2-bis(2-methylallyl)disulfane could significantly inhibit the proliferation, and induce the apoptosis of human HepG2 cells.
Keywords: 1,2-bis(2-methylallyl)disulfane; identification; apoptosis 1,2-bis(2-methylallyl)disulfane; identification; apoptosis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Ji, C.; Ren, F.; Dai, J.; Xu, M. Synthesis and Effect on Human HepG2 Cells of 1,2-bis- (2-Methylallyl)disulfane. Molecules 2010, 15, 3634-3642.

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