Next Article in Journal
Enantioselectivity Induced by Oxazaborolidine Supported on Mesoporous Silica or by Its Analog in Homogeneous Phase
Previous Article in Journal
Synthesis and Spectrosopic Identification of Hybrid 3-(Triethoxysilyl)propylamine Phosphine Ruthenium(II) Complexes
Article Menu

Article Versions

Export Article

Open AccessArticle
Molecules 2010, 15(5), 3634-3642; https://doi.org/10.3390/molecules15053634

Synthesis and Effect on Human HepG2 Cells of 1,2-bis- (2-Methylallyl)disulfane

1
College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, China
2
Research Institute for Molecular Pharmacology and Therapeutics, Central South University, Changsha, Hunan 410083, China
*
Author to whom correspondence should be addressed.
Received: 16 April 2010 / Revised: 11 May 2010 / Accepted: 12 May 2010 / Published: 18 May 2010
Download PDF [326 KB, uploaded 18 June 2014]

Abstract

1,2-bis(2-methylallyl)disulfane was synthesized from sodium sulfide and 3-chloro-2-methylpropylene. The structure of the target product was confirmed by GC-MS, 1H-NMR and elemental analysis. Cell viability assay, flow-cytometric analysis and protein expression results showed that 1,2-bis(2-methylallyl)disulfane could significantly inhibit the proliferation, and induce the apoptosis of human HepG2 cells.
Keywords: 1,2-bis(2-methylallyl)disulfane; identification; apoptosis 1,2-bis(2-methylallyl)disulfane; identification; apoptosis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Ji, C.; Ren, F.; Dai, J.; Xu, M. Synthesis and Effect on Human HepG2 Cells of 1,2-bis- (2-Methylallyl)disulfane. Molecules 2010, 15, 3634-3642.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top