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Molecules 2010, 15(5), 3079-3086; doi:10.3390/molecules15053079

A Facile One-pot Synthesis of 1-Arylpyrazolo[3,4-d]Pyrimidin- 4-ones

1
Oujiang College, Wenzhou Universtity, Wenzhou 325035, China
2
College of Chemistry and Materials Engineering, Wenzhou Universtity, Wenzhou 325035, China
*
Author to whom correspondence should be addressed.
Received: 19 March 2010 / Revised: 9 April 2010 / Accepted: 21 April 2010 / Published: 27 April 2010
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Abstract

One pot synthesis of 1-arylpyrazolo[3,4-d]pyrimidin-4-ones by the reaction of 5-amino-N-substituted-1H-pyrazole-4-carbonitrile with different lower aliphatic acids in the presence of POCl3has been developed. The structures of all the title compounds have been confirmed by IR, 1H-NMR, 13C-NMR, and elemental analyses. Moreover, the structures of one of these compounds, 2c, was confirmed by single-crystal X-ray diffraction.
Keywords: POCl3; one-pot; RCOOH; pyrazolo[3,4-d]pyrimidine POCl3; one-pot; RCOOH; pyrazolo[3,4-d]pyrimidine
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Zhang, X.; Lin, Q.; Zhong, P. A Facile One-pot Synthesis of 1-Arylpyrazolo[3,4-d]Pyrimidin- 4-ones. Molecules 2010, 15, 3079-3086.

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