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Molecules 2010, 15(5), 3079-3086; doi:10.3390/molecules15053079

A Facile One-pot Synthesis of 1-Arylpyrazolo[3,4-d]Pyrimidin- 4-ones

1 Oujiang College, Wenzhou Universtity, Wenzhou 325035, China 2 College of Chemistry and Materials Engineering, Wenzhou Universtity, Wenzhou 325035, China
* Author to whom correspondence should be addressed.
Received: 19 March 2010 / Revised: 9 April 2010 / Accepted: 21 April 2010 / Published: 27 April 2010
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One pot synthesis of 1-arylpyrazolo[3,4-d]pyrimidin-4-ones by the reaction of 5-amino-N-substituted-1H-pyrazole-4-carbonitrile with different lower aliphatic acids in the presence of POCl3has been developed. The structures of all the title compounds have been confirmed by IR, 1H-NMR, 13C-NMR, and elemental analyses. Moreover, the structures of one of these compounds, 2c, was confirmed by single-crystal X-ray diffraction.
Keywords: POCl3; one-pot; RCOOH; pyrazolo[3,4-d]pyrimidine POCl3; one-pot; RCOOH; pyrazolo[3,4-d]pyrimidine
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zhang, X.; Lin, Q.; Zhong, P. A Facile One-pot Synthesis of 1-Arylpyrazolo[3,4-d]Pyrimidin- 4-ones. Molecules 2010, 15, 3079-3086.

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