Molecules 2010, 15(5), 3087-3120; doi:10.3390/molecules15053087
Article

Automated Synthesis of a 96 Product-Sized Library of Triazole Derivatives Using a Solid Phase Supported Copper Catalyst

1,2email, 1, 1, 1, 1, 1, 1, 1, 2email and 1,* email
Received: 29 March 2010; in revised form: 20 April 2010 / Accepted: 26 April 2010 / Published: 28 April 2010
(This article belongs to the Special Issue Click Chemistry)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: This article deal with the parallel synthesis of a 96 product-sized library using a polymer-based copper catalyst that we developed which can be easily separated from the products by simple filtration. This gave us the opportunity to use this catalyst in an automated chemical synthesis station (Chemspeed ASW-2000). Studies and results about the preparation of the catalyst, its use in different solvent systems, its recycling capabilities and its scope and limitations in the synthesis of this library will be addressed. The synthesis of the triazole library and the very good results obtained will finally be discussed.
Keywords: click chemistry; Huisgen cycloaddition; copper (I) catalysis; triazoles; supported catalyst; parallel synthesis
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MDPI and ACS Style

Jlalia, I.; Beauvineau, C.; Beauvière, S.; Önen, E.; Aufort, M.; Beauvineau, A.; Khaba, E.; Herscovici, J.; Meganem, F.; Girard, C. Automated Synthesis of a 96 Product-Sized Library of Triazole Derivatives Using a Solid Phase Supported Copper Catalyst. Molecules 2010, 15, 3087-3120.

AMA Style

Jlalia I, Beauvineau C, Beauvière S, Önen E, Aufort M, Beauvineau A, Khaba E, Herscovici J, Meganem F, Girard C. Automated Synthesis of a 96 Product-Sized Library of Triazole Derivatives Using a Solid Phase Supported Copper Catalyst. Molecules. 2010; 15(5):3087-3120.

Chicago/Turabian Style

Jlalia, Ibtissem; Beauvineau, Claire; Beauvière, Sophie; Önen, Esra; Aufort, Marie; Beauvineau, Aymeric; Khaba, Eihab; Herscovici, Jean; Meganem, Faouzi; Girard, Christian. 2010. "Automated Synthesis of a 96 Product-Sized Library of Triazole Derivatives Using a Solid Phase Supported Copper Catalyst." Molecules 15, no. 5: 3087-3120.

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