Next Article in Journal
Synthesis of N-(Methoxycarbonylthienylmethyl)thioureas and Evaluation of Their Interaction with Inducible and Neuronal Nitric Oxide Synthase
Next Article in Special Issue
Click Reactions and Boronic Acids: Applications, Issues, and Potential Solutions
Previous Article in Journal
A Facile One-pot Synthesis of 1-Arylpyrazolo[3,4-d]Pyrimidin- 4-ones
Previous Article in Special Issue
Cationic Heteroleptic Cyclometalated IridiumIII Complexes Containing Phenyl-Triazole and Triazole-Pyridine Clicked Ligands
Molecules 2010, 15(5), 3087-3120; doi:10.3390/molecules15053087
Article

Automated Synthesis of a 96 Product-Sized Library of Triazole Derivatives Using a Solid Phase Supported Copper Catalyst

1,2
,
1, 1, 1, 1, 1, 1, 1, 2
 and
1,*
1 Laboratoire de Pharmacologie Chimique et Génétique (UMR 8151 CNRS, U 1022 INSERM, IFR 2769), Ecole Nationale Supérieure de Chimie de Paris – Chimie ParisTech; 11, rue Pierre et Marie Curie, 75005 Paris, France 2 Laboratoire de Synthèse Organique et Application, Faculté des Sciences de Bizerte, Université du 7 Novembre à Carthage, 7021 Jarzouna, Bizerte, Tunisia
* Author to whom correspondence should be addressed.
Received: 29 March 2010 / Revised: 20 April 2010 / Accepted: 26 April 2010 / Published: 28 April 2010
(This article belongs to the Special Issue Click Chemistry)
Download PDF [596 KB, uploaded 18 June 2014]

Abstract

This article deal with the parallel synthesis of a 96 product-sized library using a polymer-based copper catalyst that we developed which can be easily separated from the products by simple filtration. This gave us the opportunity to use this catalyst in an automated chemical synthesis station (Chemspeed ASW-2000). Studies and results about the preparation of the catalyst, its use in different solvent systems, its recycling capabilities and its scope and limitations in the synthesis of this library will be addressed. The synthesis of the triazole library and the very good results obtained will finally be discussed.
Keywords: click chemistry; Huisgen cycloaddition; copper (I) catalysis; triazoles; supported catalyst; parallel synthesis click chemistry; Huisgen cycloaddition; copper (I) catalysis; triazoles; supported catalyst; parallel synthesis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Jlalia, I.; Beauvineau, C.; Beauvière, S.; Önen, E.; Aufort, M.; Beauvineau, A.; Khaba, E.; Herscovici, J.; Meganem, F.; Girard, C. Automated Synthesis of a 96 Product-Sized Library of Triazole Derivatives Using a Solid Phase Supported Copper Catalyst. Molecules 2010, 15, 3087-3120.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert