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Automated Synthesis of a 96 Product-Sized Library of Triazole Derivatives Using a Solid Phase Supported Copper Catalyst
Laboratoire de Pharmacologie Chimique et Génétique (UMR 8151 CNRS, U 1022 INSERM, IFR 2769), Ecole Nationale Supérieure de Chimie de Paris – Chimie ParisTech; 11, rue Pierre et Marie Curie, 75005 Paris, France
Laboratoire de Synthèse Organique et Application, Faculté des Sciences de Bizerte, Université du 7 Novembre à Carthage, 7021 Jarzouna, Bizerte, Tunisia
* Author to whom correspondence should be addressed.
Received: 29 March 2010; in revised form: 20 April 2010 / Accepted: 26 April 2010 / Published: 28 April 2010
Abstract: This article deal with the parallel synthesis of a 96 product-sized library using a polymer-based copper catalyst that we developed which can be easily separated from the products by simple filtration. This gave us the opportunity to use this catalyst in an automated chemical synthesis station (Chemspeed ASW-2000). Studies and results about the preparation of the catalyst, its use in different solvent systems, its recycling capabilities and its scope and limitations in the synthesis of this library will be addressed. The synthesis of the triazole library and the very good results obtained will finally be discussed.
Keywords: click chemistry; Huisgen cycloaddition; copper (I) catalysis; triazoles; supported catalyst; parallel synthesis
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MDPI and ACS Style
Jlalia, I.; Beauvineau, C.; Beauvière, S.; Önen, E.; Aufort, M.; Beauvineau, A.; Khaba, E.; Herscovici, J.; Meganem, F.; Girard, C. Automated Synthesis of a 96 Product-Sized Library of Triazole Derivatives Using a Solid Phase Supported Copper Catalyst. Molecules 2010, 15, 3087-3120.
Jlalia I, Beauvineau C, Beauvière S, Önen E, Aufort M, Beauvineau A, Khaba E, Herscovici J, Meganem F, Girard C. Automated Synthesis of a 96 Product-Sized Library of Triazole Derivatives Using a Solid Phase Supported Copper Catalyst. Molecules. 2010; 15(5):3087-3120.
Jlalia, Ibtissem; Beauvineau, Claire; Beauvière, Sophie; Önen, Esra; Aufort, Marie; Beauvineau, Aymeric; Khaba, Eihab; Herscovici, Jean; Meganem, Faouzi; Girard, Christian. 2010. "Automated Synthesis of a 96 Product-Sized Library of Triazole Derivatives Using a Solid Phase Supported Copper Catalyst." Molecules 15, no. 5: 3087-3120.