Next Article in Journal
Elucidating Drug-Enzyme Interactions and Their Structural Basis for Improving the Affinity and Potency of Isoniazid and Its Derivatives Based on Computer Modeling Approaches
Previous Article in Journal
A General and Simple Diastereoselective Reduction by L-Selectride: Efficient Synthesis of Protected (4S,5S)-Dihydroxy Amides
Molecules 2010, 15(4), 2782-2790; doi:10.3390/molecules15042782

p-Aminoacetophenonic Acids Produced by a Mangrove Endophyte Streptomyces sp. (strain HK10552)

1,3,* , 2,* , 4
1 State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China 2 School of Pharmaceutical Sciences, Shangxi Medical University, Shanxi 030001, China 3 Shanghai Center for Systems Biomedicine, Shanghai Jiaotong University, Shanghai 200240, China 4 Leibniz Institute for Natural Products Research and Infection Biology, Hans-Knöll Institute, Beutenbergstr.11a, D-07745 Jena, Germany
* Authors to whom correspondence should be addressed.
Received: 18 March 2010 / Revised: 31 March 2010 / Accepted: 6 April 2010 / Published: 16 April 2010
Download PDF [234 KB, uploaded 18 June 2014]


Four new p-aminoacetophenonic acids, named (2E)-11-(4′-aminophenyl)-5,9-dihydroxy-4,6,8-trimethyl-11-oxo-undec-2-enoic acid (1), 9-(4′-aminophenyl)-3,7-dihydroxy-2,4,6-trimethyl-9-oxo-nonoic acid(2), (2E)-11-(4′-aminophenyl)-5,9-O-cyclo-4,6,8-trimethyl-11-oxo-undec-2-enoic acid (3) and 9-(4′-aminophenyl)-3,7-O-cyclo-2,4,6-trimethyl-9-oxo-nonoic acid(4), were isolated from an endophyte Streptomyces sp. (strain HK10552) of the mangrove plant Aegiceras corniculatum. The structures of 14 were elucidated by using spectroscopic analyses. The relative stereoconfigurations of compounds 3 and 4 were determined by NOESY experiments. In the bioassay test, 14 showed no cytotoxicity against the Hela cell lines. Compound 4 also showed no inhibitory bioactivity on HCV protease and SecA ATPase and wasn’t active against VSVG/HIV-luc pseudotyping virus.
Keywords: p-aminoacetophenonic acids; endophyte; mangrove plant; Aegiceras corniculatum p-aminoacetophenonic acids; endophyte; mangrove plant; Aegiceras corniculatum
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Wang, F.; Xu, M.; Li, Q.; Sattler, I.; Lin, W. p-Aminoacetophenonic Acids Produced by a Mangrove Endophyte Streptomyces sp. (strain HK10552). Molecules 2010, 15, 2782-2790.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert