Molecules 2010, 15(4), 2782-2790; doi:10.3390/molecules15042782
Article

p-Aminoacetophenonic Acids Produced by a Mangrove Endophyte Streptomyces sp. (strain HK10552)

1,2email, 1,3,* email, 2,* email, 4email and 1,2email
Received: 18 March 2010; in revised form: 31 March 2010 / Accepted: 6 April 2010 / Published: 16 April 2010
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Four new p-aminoacetophenonic acids, named (2E)-11-(4′-aminophenyl)-5,9-dihydroxy-4,6,8-trimethyl-11-oxo-undec-2-enoic acid (1), 9-(4′-aminophenyl)-3,7-dihydroxy-2,4,6-trimethyl-9-oxo-nonoic acid(2), (2E)-11-(4′-aminophenyl)-5,9-O-cyclo-4,6,8-trimethyl-11-oxo-undec-2-enoic acid (3) and 9-(4′-aminophenyl)-3,7-O-cyclo-2,4,6-trimethyl-9-oxo-nonoic acid(4), were isolated from an endophyte Streptomyces sp. (strain HK10552) of the mangrove plant Aegiceras corniculatum. The structures of 14 were elucidated by using spectroscopic analyses. The relative stereoconfigurations of compounds 3 and 4 were determined by NOESY experiments. In the bioassay test, 14 showed no cytotoxicity against the Hela cell lines. Compound 4 also showed no inhibitory bioactivity on HCV protease and SecA ATPase and wasn’t active against VSVG/HIV-luc pseudotyping virus.
Keywords: p-aminoacetophenonic acids; endophyte; mangrove plant; Aegiceras corniculatum
PDF Full-text Download PDF Full-Text [234 KB, uploaded 18 June 2014 19:32 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Wang, F.; Xu, M.; Li, Q.; Sattler, I.; Lin, W. p-Aminoacetophenonic Acids Produced by a Mangrove Endophyte Streptomyces sp. (strain HK10552). Molecules 2010, 15, 2782-2790.

AMA Style

Wang F, Xu M, Li Q, Sattler I, Lin W. p-Aminoacetophenonic Acids Produced by a Mangrove Endophyte Streptomyces sp. (strain HK10552). Molecules. 2010; 15(4):2782-2790.

Chicago/Turabian Style

Wang, Fangfang; Xu, Minjuan; Li, Qingshan; Sattler, Isable; Lin, Wenhan. 2010. "p-Aminoacetophenonic Acids Produced by a Mangrove Endophyte Streptomyces sp. (strain HK10552)." Molecules 15, no. 4: 2782-2790.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert