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p-Aminoacetophenonic Acids Produced by a Mangrove Endophyte Streptomyces sp. (strain HK10552)
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China
School of Pharmaceutical Sciences, Shangxi Medical University, Shanxi 030001, China
Shanghai Center for Systems Biomedicine, Shanghai Jiaotong University, Shanghai 200240, China
Leibniz Institute for Natural Products Research and Infection Biology, Hans-Knöll Institute, Beutenbergstr.11a, D-07745 Jena, Germany
* Authors to whom correspondence should be addressed.
Received: 18 March 2010; in revised form: 31 March 2010 / Accepted: 6 April 2010 / Published: 16 April 2010
Abstract: Four new p-aminoacetophenonic acids, named (2E)-11-(4′-aminophenyl)-5,9-dihydroxy-4,6,8-trimethyl-11-oxo-undec-2-enoic acid (1), 9-(4′-aminophenyl)-3,7-dihydroxy-2,4,6-trimethyl-9-oxo-nonoic acid(2), (2E)-11-(4′-aminophenyl)-5,9-O-cyclo-4,6,8-trimethyl-11-oxo-undec-2-enoic acid (3) and 9-(4′-aminophenyl)-3,7-O-cyclo-2,4,6-trimethyl-9-oxo-nonoic acid(4), were isolated from an endophyte Streptomyces sp. (strain HK10552) of the mangrove plant Aegiceras corniculatum. The structures of 1–4 were elucidated by using spectroscopic analyses. The relative stereoconfigurations of compounds 3 and 4 were determined by NOESY experiments. In the bioassay test, 1–4 showed no cytotoxicity against the Hela cell lines. Compound 4 also showed no inhibitory bioactivity on HCV protease and SecA ATPase and wasn’t active against VSVG/HIV-luc pseudotyping virus.
Keywords: p-aminoacetophenonic acids; endophyte; mangrove plant; Aegiceras corniculatum
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Wang, F.; Xu, M.; Li, Q.; Sattler, I.; Lin, W. p-Aminoacetophenonic Acids Produced by a Mangrove Endophyte Streptomyces sp. (strain HK10552). Molecules 2010, 15, 2782-2790.
Wang F, Xu M, Li Q, Sattler I, Lin W. p-Aminoacetophenonic Acids Produced by a Mangrove Endophyte Streptomyces sp. (strain HK10552). Molecules. 2010; 15(4):2782-2790.
Wang, Fangfang; Xu, Minjuan; Li, Qingshan; Sattler, Isable; Lin, Wenhan. 2010. "p-Aminoacetophenonic Acids Produced by a Mangrove Endophyte Streptomyces sp. (strain HK10552)." Molecules 15, no. 4: 2782-2790.