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Molecules 2010, 15(4), 2203-2210; doi:10.3390/molecules15042203
Article

Gold(I) Complexes of N-Heterocyclic Carbene Ligands Containing Benzimidazole: Synthesis and Antimicrobial Activity

1,* , 1
,
2
 and
1,*
1 Department of Chemistry, Faculty of Science and Art, İnönü University, 44280 Malatya, Turkey 2 Department of Microbiology, Faculty of Medicine, İnönü University, 44280 Malatya, Turkey
* Authors to whom correspondence should be addressed.
Received: 15 March 2010 / Revised: 23 March 2010 / Accepted: 26 March 2010 / Published: 29 March 2010
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Abstract

Gold(I) N-heterocyclic carbene (NHC) complexes were obtained in good yields from the corresponding silver complexes by treatment with [AuCl(PPh3)] following the commonly used silver carbene transfer route. The silver complexes were synthesized from the benzimidazolium halide salts by the in situ reactions with Ag2O in dichloromethane as a solvent at room temperature. All gold complexes have been characterized by 1H-NMR, 13C-NMR and IR spectroscopy and elemental analysis. Au-NHC complexes were evaluated for their in vitro antimicrobial activity against a variety of Gram-positive and Gram-negative bacteria and fungal species.
Keywords: gold; N-heterocyclic carbene; metallopharmaceutical agent; antimicrobial; benzimidazol-2-ylidene gold; N-heterocyclic carbene; metallopharmaceutical agent; antimicrobial; benzimidazol-2-ylidene
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Özdemir, İ.; Temelli, N.; Günal, S.; Demir, S. Gold(I) Complexes of N-Heterocyclic Carbene Ligands Containing Benzimidazole: Synthesis and Antimicrobial Activity. Molecules 2010, 15, 2203-2210.

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