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• Özdemir, İ
• Temelli, N
• Günal, S
• Demir, S
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• Temelli, N
• Günal, S
• Demir, S
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• Temelli, N
• Günal, S
• Demir, S

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Molecules 2010, 15(4), 2203-2210; doi:10.3390/molecules15042203

Article

Gold(I) Complexes of N-Heterocyclic Carbene Ligands Containing Benzimidazole: Synthesis and Antimicrobial Activity

İlknur Özdemir ^1,* , Nazan Temelli ¹ , Selami Günal ²  and Serpil Demir ^1,*

¹ Department of Chemistry, Faculty of Science and Art, İnönü University, 44280 Malatya, Turkey ² Department of Microbiology, Faculty of Medicine, İnönü University, 44280 Malatya, Turkey

* Authors to whom correspondence should be addressed.

Received: 15 March 2010; in revised form: 23 March 2010 / Accepted: 26 March 2010 / Published: 29 March 2010

Download PDF Full-Text [352 KB, uploaded 29 March 2010 11:17 CEST]

Abstract: Gold(I) N-heterocyclic carbene (NHC) complexes were obtained in good yields from the corresponding silver complexes by treatment with [AuCl(PPh₃)] following the commonly used silver carbene transfer route. The silver complexes were synthesized from the benzimidazolium halide salts by the in situ reactions with Ag₂O in dichloromethane as a solvent at room temperature. All gold complexes have been characterized by ¹H-NMR, ¹³C-NMR and IR spectroscopy and elemental analysis. Au-NHC complexes were evaluated for their in vitro antimicrobial activity against a variety of Gram-positive and Gram-negative bacteria and fungal species.

Keywords: gold; N-heterocyclic carbene; metallopharmaceutical agent; antimicrobial; benzimidazol-2-ylidene

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