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Novel Indole-Based Analogs of Melatonin: Synthesis and in Vitro Antioxidant Activity Studies
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, 06100 Tandogan, Ankara, Turkey
Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Ege University, 35100 Bornova, Izmir, Turkey
* Author to whom correspondence should be addressed.
Received: 19 January 2010; in revised form: 15 March 2010 / Accepted: 23 March 2010 / Published: 29 March 2010
Abstract: The aim of this study was to synthesize and examine possible in vitro antioxidant effects of indole-based melatonin analogue compounds. As a part of our ongoing study nineteen indole hydrazide/hydrazone derivatives were synthesized, characterized and their in vitro antioxidant activity was investigated by three different assays: by evaluating their reducing effect against oxidation of a redox sensitive fluorescent probe, by examining their protective effect against H2O2-induced membrane lipid peroxidation and by determining their inhibitory effect on AAPH–induced hemolysis of human erythrocytes. The results indicated significant strong antioxidant activity for most of the compounds, when compared to melatonin.
Keywords: indole; hydrazone; hydrazide; melatonin; synthesis; antioxidant activity
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Shirinzadeh, H.; Eren, B.; Gurer-Orhan, H.; Suzen, S.; Özden, S. Novel Indole-Based Analogs of Melatonin: Synthesis and in Vitro Antioxidant Activity Studies. Molecules 2010, 15, 2187-2202.
Shirinzadeh H, Eren B, Gurer-Orhan H, Suzen S, Özden S. Novel Indole-Based Analogs of Melatonin: Synthesis and in Vitro Antioxidant Activity Studies. Molecules. 2010; 15(4):2187-2202.
Shirinzadeh, Hanif; Eren, Burcu; Gurer-Orhan, Hande; Suzen, Sibel; Özden, Seçkin. 2010. "Novel Indole-Based Analogs of Melatonin: Synthesis and in Vitro Antioxidant Activity Studies." Molecules 15, no. 4: 2187-2202.