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Molecules 2010, 15(4), 2114-2123; doi:10.3390/molecules15042114

Synthesis and Biological Evaluation of New 5-Fluorouracil-Substituted Ampelopsin Derivatives

1 School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China 2 Guangdong Food and Drug Vocational College, Guangzhou 510520, China These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 19 January 2010 / Revised: 15 March 2010 / Accepted: 22 March 2010 / Published: 24 March 2010
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This study reports two novel 5-fluorouracil-substituted ampelopsin derivatives. The structures of two new derivatives were characterized by elemental analysis, 1H-NMR, 13C-NMR, IR and MS. Their anticancer activities in vitro against two cancer cell lines, K562 and K562/ADR, were investigated using the MTT assay, and the results showed that the two new compounds were more effective than reference drugs such as ampelopsin and verapamil.
Keywords: ampelopsin; 5-fluorouracil; anticancer activity ampelopsin; 5-fluorouracil; anticancer activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Zhou, W.-M.; He, R.-R.; Ye, J.-T.; Zhang, N.; Liu, D.-Y. Synthesis and Biological Evaluation of New 5-Fluorouracil-Substituted Ampelopsin Derivatives. Molecules 2010, 15, 2114-2123.

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