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• He, R
• Ye, J
• Zhang, N
• Liu, D
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• He, R
• Ye, J
• Zhang, N
• Liu, D
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• He, R
• Ye, J
• Zhang, N
• Liu, D

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Molecules 2010, 15(4), 2114-2123; doi:10.3390/molecules15042114

Article

Synthesis and Biological Evaluation of New 5-Fluorouracil-Substituted Ampelopsin Derivatives

Wei-Ming Zhou^1,2, , Rong-Rong He^1, , Jian-Tao Ye¹ , Na Zhang¹  and De-Yu Liu^1,*

¹ School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China ² Guangdong Food and Drug Vocational College, Guangzhou 510520, China These authors contributed equally to this work.

* Author to whom correspondence should be addressed.

Received: 19 January 2010; in revised form: 15 March 2010 / Accepted: 22 March 2010 / Published: 24 March 2010

Download PDF Full-Text [299 KB, uploaded 24 March 2010 14:51 CET]

Abstract: This study reports two novel 5-fluorouracil-substituted ampelopsin derivatives. The structures of two new derivatives were characterized by elemental analysis, ¹H-NMR, ¹³C-NMR, IR and MS. Their anticancer activities in vitro against two cancer cell lines, K562 and K562/ADR, were investigated using the MTT assay, and the results showed that the two new compounds were more effective than reference drugs such as ampelopsin and verapamil.

Keywords: ampelopsin; 5-fluorouracil; anticancer activity

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