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Molecules 2010, 15(4), 2114-2123; doi:10.3390/molecules15042114

Synthesis and Biological Evaluation of New 5-Fluorouracil-Substituted Ampelopsin Derivatives

1 School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China 2 Guangdong Food and Drug Vocational College, Guangzhou 510520, China These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 19 January 2010 / Revised: 15 March 2010 / Accepted: 22 March 2010 / Published: 24 March 2010
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This study reports two novel 5-fluorouracil-substituted ampelopsin derivatives. The structures of two new derivatives were characterized by elemental analysis, 1H-NMR, 13C-NMR, IR and MS. Their anticancer activities in vitro against two cancer cell lines, K562 and K562/ADR, were investigated using the MTT assay, and the results showed that the two new compounds were more effective than reference drugs such as ampelopsin and verapamil.
Keywords: ampelopsin; 5-fluorouracil; anticancer activity ampelopsin; 5-fluorouracil; anticancer activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zhou, W.-M.; He, R.-R.; Ye, J.-T.; Zhang, N.; Liu, D.-Y. Synthesis and Biological Evaluation of New 5-Fluorouracil-Substituted Ampelopsin Derivatives. Molecules 2010, 15, 2114-2123.

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