Synthesis and Biological Evaluation of New 5-Fluorouracil-Substituted Ampelopsin Derivatives

doi:10.3390/molecules15042114

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Molecules 2010, 15(4), 2114-2123; doi:10.3390/molecules15042114

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Synthesis and Biological Evaluation of New 5-Fluorouracil-Substituted Ampelopsin Derivatives

Wei-Ming Zhou^1,2,, Rong-Rong He^1,, Jian-Tao Ye¹, Na Zhang¹ and De-Yu Liu^1,*

¹ School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China ² Guangdong Food and Drug Vocational College, Guangzhou 510520, China These authors contributed equally to this work.

* Author to whom correspondence should be addressed.

Received: 19 January 2010; in revised form: 15 March 2010 / Accepted: 22 March 2010 / Published: 24 March 2010

Download PDF Full-Text [299 KB, uploaded 24 March 2010 14:51 CET]

Abstract: This study reports two novel 5-fluorouracil-substituted ampelopsin derivatives. The structures of two new derivatives were characterized by elemental analysis, ¹H-NMR, ¹³C-NMR, IR and MS. Their anticancer activities in vitro against two cancer cell lines, K562 and K562/ADR, were investigated using the MTT assay, and the results showed that the two new compounds were more effective than reference drugs such as ampelopsin and verapamil.

Keywords: ampelopsin; 5-fluorouracil; anticancer activity

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MDPI and ACS Style

Zhou, W.-M.; He, R.-R.; Ye, J.-T.; Zhang, N.; Liu, D.-Y. Synthesis and Biological Evaluation of New 5-Fluorouracil-Substituted Ampelopsin Derivatives. Molecules 2010, 15, 2114-2123.

AMA Style

Zhou W-M, He R-R, Ye J-T, Zhang N, Liu D-Y. Synthesis and Biological Evaluation of New 5-Fluorouracil-Substituted Ampelopsin Derivatives. Molecules. 2010; 15(4):2114-2123.

Chicago/Turabian Style

Zhou, Wei-Ming; He, Rong-Rong; Ye, Jian-Tao; Zhang, Na; Liu, De-Yu. 2010. "Synthesis and Biological Evaluation of New 5-Fluorouracil-Substituted Ampelopsin Derivatives." Molecules 15, no. 4: 2114-2123.

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