Molecules 2010, 15(3), 1554-1561; doi:10.3390/molecules15031554

Allelochemical, Eudesmane-Type Sesquiterpenoids from Inula falconeri

1,2, 2, 1, 1, 4, 3 and 1,* email
Received: 15 December 2009; in revised form: 25 January 2010 / Accepted: 5 March 2010 / Published: 10 March 2010
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: We have identified through bioassay guided isolation an allelochemical, eudesmane-type sesquiterpeniod, 3β-caffeoxyl-β1,8α-dihydroxyeudesm-4(15)-ene(1),from an endemic plant species growing in the Himalayas. In our search for the bioactive subfraction, the hexane one was highly significant, showing 100% inhibition of lettuce seed growth at 100 ppm while other subfractions (chloroform, ethyl acetate, butanol and water) exhibited inhibitory to stimulatory allelopathic effects. The bioactive hexane subfraction was subjected to chromatographic techniques, using lettuce seeds (Lactuca sativa) as indicator species to reveal the bioactive allelopathic fraction. This resulted in the isolation of compound 1, whose structure was elucidated through NMR techniques. The compound presented 92.34% inhibitory effect on the growth of lettuce at 500 ppm. Further field level experiments may help develop an environmentally friendly herbicide from this lead.
Keywords: Inula falconeri; eudesmane sesquiterpenes; allelopathic effect
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MDPI and ACS Style

Khan, A.L.; Hussain, J.; Hamayun, M.; Kang, S.-M.; Kim, H.-Y.; Watanabe, K.N.; Lee, I.-J. Allelochemical, Eudesmane-Type Sesquiterpenoids from Inula falconeri . Molecules 2010, 15, 1554-1561.

AMA Style

Khan AL, Hussain J, Hamayun M, Kang S-M, Kim H-Y, Watanabe KN, Lee I-J. Allelochemical, Eudesmane-Type Sesquiterpenoids from Inula falconeri . Molecules. 2010; 15(3):1554-1561.

Chicago/Turabian Style

Khan, Abdul Latif; Hussain, Javid; Hamayun, Muhammad; Kang, Sang-Mo; Kim, Hak-Youn; Watanabe, Kazuo N.; Lee, In-Jung. 2010. "Allelochemical, Eudesmane-Type Sesquiterpenoids from Inula falconeri ." Molecules 15, no. 3: 1554-1561.

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