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Allelochemical, Eudesmane-Type Sesquiterpenoids from Inula falconeri
School of Plant Biosciences, College of Agriculture and Life Sciences, Kyungpook National University, Daegu, Korea
Kohat University of Science & Technology, Kohat 26000, NWFP, Pakistan
Gene Research Center, University of Tsukuba, Ibaraki, Japan
Department of Environmental Conservation and Disaster Prevention, College of Environment, Keimyung University, Daegu, Korea
* Author to whom correspondence should be addressed.
Received: 15 December 2009; in revised form: 25 January 2010 / Accepted: 5 March 2010 / Published: 10 March 2010
Abstract: We have identified through bioassay guided isolation an allelochemical, eudesmane-type sesquiterpeniod, 3β-caffeoxyl-β1,8α-dihydroxyeudesm-4(15)-ene(1),from an endemic plant species growing in the Himalayas. In our search for the bioactive subfraction, the hexane one was highly significant, showing 100% inhibition of lettuce seed growth at 100 ppm while other subfractions (chloroform, ethyl acetate, butanol and water) exhibited inhibitory to stimulatory allelopathic effects. The bioactive hexane subfraction was subjected to chromatographic techniques, using lettuce seeds (Lactuca sativa) as indicator species to reveal the bioactive allelopathic fraction. This resulted in the isolation of compound 1, whose structure was elucidated through NMR techniques. The compound presented 92.34% inhibitory effect on the growth of lettuce at 500 ppm. Further field level experiments may help develop an environmentally friendly herbicide from this lead.
Keywords: Inula falconeri; eudesmane sesquiterpenes; allelopathic effect
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MDPI and ACS Style
Khan, A.L.; Hussain, J.; Hamayun, M.; Kang, S.-M.; Kim, H.-Y.; Watanabe, K.N.; Lee, I.-J. Allelochemical, Eudesmane-Type Sesquiterpenoids from Inula falconeri . Molecules 2010, 15, 1554-1561.
Khan AL, Hussain J, Hamayun M, Kang S-M, Kim H-Y, Watanabe KN, Lee I-J. Allelochemical, Eudesmane-Type Sesquiterpenoids from Inula falconeri . Molecules. 2010; 15(3):1554-1561.
Khan, Abdul Latif; Hussain, Javid; Hamayun, Muhammad; Kang, Sang-Mo; Kim, Hak-Youn; Watanabe, Kazuo N.; Lee, In-Jung. 2010. "Allelochemical, Eudesmane-Type Sesquiterpenoids from Inula falconeri ." Molecules 15, no. 3: 1554-1561.