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Identification of Major Phenolic Compounds from Nephelium lappaceum L. and Their Antioxidant Activities
Division of Biotechnology, Graduate School, Chiang Mai University, Chiang Mai, 50200, Thailand
Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai, 50200, Thailand
School of Chemistry, University of Southampton, Southampton, SO17 1BJ, UK
* Authors to whom correspondence should be addressed.
Received: 21 January 2010; in revised form: 5 March 2010 / Accepted: 8 March 2010 / Published: 9 March 2010
Abstract: Nephelium lappaceum is a tropical fruit whose peel possesses antioxidant properties. Experiments on the isolation and identification of the active constituents were conducted, and on their antioxidant activity using a lipid peroxidation inhibition assay. The methanolic extract of N. lappaceum peels exhibited strong antioxidant properties. Sephadex LH-20 chromatography was utilized in the isolation of each constituent and the antioxidant properties of each was studied. The isolated compounds were identified as ellagic acid (EA) (1), corilagin (2) and geraniin (3). These compounds accounted for 69.3% of methanolic extract, with geraniin (56.8%) as the major component, and exhibited much greater antioxidant activities than BHT in both lipid peroxidation (77-186 fold) and DPPH• (42-87 fold) assays. The results suggest that the isolated ellagitannins, as the principal components of rambutan peels, could be further utilized as both a medicine and in the food industry.
Keywords: Nephelium lappaceum; antioxidant; geraniin; corilagin; ellagic acid; phenolic compounds
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Thitilertdecha, N.; Teerawutgulrag, A.; Kilburn, J.D.; Rakariyatham, N. Identification of Major Phenolic Compounds from Nephelium lappaceum L. and Their Antioxidant Activities. Molecules 2010, 15, 1453-1465.
Thitilertdecha N, Teerawutgulrag A, Kilburn JD, Rakariyatham N. Identification of Major Phenolic Compounds from Nephelium lappaceum L. and Their Antioxidant Activities. Molecules. 2010; 15(3):1453-1465.
Thitilertdecha, Nont; Teerawutgulrag, Aphiwat; Kilburn, Jeremy D.; Rakariyatham, Nuansri. 2010. "Identification of Major Phenolic Compounds from Nephelium lappaceum L. and Their Antioxidant Activities." Molecules 15, no. 3: 1453-1465.