Molecules 2010, 15(3), 1280-1290; doi:10.3390/molecules15031280
Article

Catalytic Asymmetric Nitro-Mannich Reactions with a Yb/K Heterobimetallic Catalyst

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
* Authors to whom correspondence should be addressed.
Received: 1 February 2010; in revised form: 10 February 2010 / Accepted: 2 March 2010 / Published: 4 March 2010
(This article belongs to the Special Issue Bifunctional Catalysis)
PDF Full-text Download PDF Full-Text [158 KB, uploaded 4 March 2010 08:33 CET]
Abstract: A catalytic asymmetric nitro-Mannich (aza-Henry) reaction with rare earth metal/alkali metal heterobimetallic catalysts is described. A Yb/K heterobimetallic catalyst assembled by an amide-based ligand promoted the asymmetric nitro-Mannich reaction to afford enantioenriched anti-b-nitroamines in up to 86% ee. Facile reduction of the nitro functionality allowed for efficient access to optically active 1,2-diamines.
Keywords: nitro-Mannich; ytterbium; heterobimetallic; asymmetric catalysis; amide-based ligand

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Nitabaru, T.; Kumagai, N.; Shibasaki, M. Catalytic Asymmetric Nitro-Mannich Reactions with a Yb/K Heterobimetallic Catalyst. Molecules 2010, 15, 1280-1290.

AMA Style

Nitabaru T, Kumagai N, Shibasaki M. Catalytic Asymmetric Nitro-Mannich Reactions with a Yb/K Heterobimetallic Catalyst. Molecules. 2010; 15(3):1280-1290.

Chicago/Turabian Style

Nitabaru, Tatsuya; Kumagai, Naoya; Shibasaki, Masakatsu. 2010. "Catalytic Asymmetric Nitro-Mannich Reactions with a Yb/K Heterobimetallic Catalyst." Molecules 15, no. 3: 1280-1290.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert