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Molecules 2010, 15(3), 1280-1290; doi:10.3390/molecules15031280
Article

Catalytic Asymmetric Nitro-Mannich Reactions with a Yb/K Heterobimetallic Catalyst

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Received: 1 February 2010; in revised form: 10 February 2010 / Accepted: 2 March 2010 / Published: 4 March 2010
(This article belongs to the Special Issue Bifunctional Catalysis)
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Abstract: A catalytic asymmetric nitro-Mannich (aza-Henry) reaction with rare earth metal/alkali metal heterobimetallic catalysts is described. A Yb/K heterobimetallic catalyst assembled by an amide-based ligand promoted the asymmetric nitro-Mannich reaction to afford enantioenriched anti-b-nitroamines in up to 86% ee. Facile reduction of the nitro functionality allowed for efficient access to optically active 1,2-diamines.
Keywords: nitro-Mannich; ytterbium; heterobimetallic; asymmetric catalysis; amide-based ligand nitro-Mannich; ytterbium; heterobimetallic; asymmetric catalysis; amide-based ligand
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Nitabaru, T.; Kumagai, N.; Shibasaki, M. Catalytic Asymmetric Nitro-Mannich Reactions with a Yb/K Heterobimetallic Catalyst. Molecules 2010, 15, 1280-1290.

AMA Style

Nitabaru T, Kumagai N, Shibasaki M. Catalytic Asymmetric Nitro-Mannich Reactions with a Yb/K Heterobimetallic Catalyst. Molecules. 2010; 15(3):1280-1290.

Chicago/Turabian Style

Nitabaru, Tatsuya; Kumagai, Naoya; Shibasaki, Masakatsu. 2010. "Catalytic Asymmetric Nitro-Mannich Reactions with a Yb/K Heterobimetallic Catalyst." Molecules 15, no. 3: 1280-1290.


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