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Molecules 2010, 15(3), 1270-1279; doi:10.3390/molecules15031270
Communication

Selective Growth Inhibitory Effect of Biochanin A Against Intestinal Tract Colonizing Bacteria

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Received: 13 January 2010 / Revised: 5 February 2010 / Accepted: 1 March 2010 / Published: 3 March 2010
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Abstract

Both bifidobacteria and clostridia are part of the natural gut microflora and while clostridia may be responsible for severe intestinal infections, bifidobacteria are probiotic microorganisms belonging to the most important prospective bacteria in the bowel. The antimicrobial activity of biochanin A was tested in vitro against six Bifidobacterium spp., and eight Clostridium spp. using the broth microdilution method. Biochanin A showed an inhibition against all clostridia in the range of minimum inhibitory concentrations (MIC) from 64 μg/mL (for Cl. clostridioforme, strains DSM 933 and I3) to 1,024 μg/mL (for Cl. perfringens, DSM 11778). No bifidobacteria were suppressed at four-fold higher concentration (MICs > 4,096) than MIC of Cl. perfringens. These results indicate selective growth inhibition of biochanin A and its potential use in antimicrobial prevention and/or protection.
Keywords: phytoestrogen; isoflavonoid; bifidobacteria; clostridia; selective antimicrobial activity phytoestrogen; isoflavonoid; bifidobacteria; clostridia; selective antimicrobial activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Sklenickova, O.; Flesar, J.; Kokoska, L.; Vlkova, E.; Halamova, K.; Malik, J. Selective Growth Inhibitory Effect of Biochanin A Against Intestinal Tract Colonizing Bacteria. Molecules 2010, 15, 1270-1279.

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