Next Article in Journal
Catalytic Asymmetric Nitro-Mannich Reactions with a Yb/K Heterobimetallic Catalyst
Previous Article in Journal
Prodrug Approach for Increasing Cellular Glutathione Levels
Article Menu

Article Versions

Export Article

Open AccessCommunication
Molecules 2010, 15(3), 1270-1279; doi:10.3390/molecules15031270

Selective Growth Inhibitory Effect of Biochanin A Against Intestinal Tract Colonizing Bacteria

1
Department of Crop Sciences and Agroforestry, Institute of Tropics and Subtropics, Czech University of Life Sciences Prague, Kamycka 129, Prague 6, 165 21, Czech Republic
2
Department of Microbiology, Nutrition and Dietetics, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Kamycka 129, Prague 6, 165 21, Czech Republic
*
Author to whom correspondence should be addressed.
Received: 13 January 2010 / Revised: 5 February 2010 / Accepted: 1 March 2010 / Published: 3 March 2010
Download PDF [181 KB, uploaded 18 June 2014]

Abstract

Both bifidobacteria and clostridia are part of the natural gut microflora and while clostridia may be responsible for severe intestinal infections, bifidobacteria are probiotic microorganisms belonging to the most important prospective bacteria in the bowel. The antimicrobial activity of biochanin A was tested in vitro against six Bifidobacterium spp., and eight Clostridium spp. using the broth microdilution method. Biochanin A showed an inhibition against all clostridia in the range of minimum inhibitory concentrations (MIC) from 64 μg/mL (for Cl. clostridioforme, strains DSM 933 and I3) to 1,024 μg/mL (for Cl. perfringens, DSM 11778). No bifidobacteria were suppressed at four-fold higher concentration (MICs > 4,096) than MIC of Cl. perfringens. These results indicate selective growth inhibition of biochanin A and its potential use in antimicrobial prevention and/or protection.
Keywords: phytoestrogen; isoflavonoid; bifidobacteria; clostridia; selective antimicrobial activity phytoestrogen; isoflavonoid; bifidobacteria; clostridia; selective antimicrobial activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Sklenickova, O.; Flesar, J.; Kokoska, L.; Vlkova, E.; Halamova, K.; Malik, J. Selective Growth Inhibitory Effect of Biochanin A Against Intestinal Tract Colonizing Bacteria. Molecules 2010, 15, 1270-1279.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top