Next Article in Journal
Previous Article in Journal
Molecules 2010, 15(12), 9403-9417; doi:10.3390/molecules15129403
Article

Synthesis of 2-(4,6-Dimethoxy-1,3,5-triazin-2-yloxyimino) Derivatives: Application in Solution Peptide Synthesis

1,* , 2, 2,3 and 4,5,6
Received: 29 November 2010; in revised form: 14 December 2010 / Accepted: 15 December 2010 / Published: 20 December 2010
Download PDF [158 KB, uploaded 18 June 2014]
Abstract: A new class of 1,3,5-triazinyloxyimino derivatives were prepared, characterized and tested for reactivity in solution peptide synthesis. The new triazinyloxyimino derivatives failed to activate the carboxyl group during formation of peptide bonds, but gave the corresponding N-triazinyl amino acid derivatives as a major product. The oxyma (ethyl 2-cyano-2-(hydroxyimino)acetate) uronium salt was superior to other uronium salts in terms of racemization, while 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT, 9) gave the best results.
Keywords: coupling reagents; triazinyloximino derivatives; solution phase peptide synthesis; uronium salt; racemization coupling reagents; triazinyloximino derivatives; solution phase peptide synthesis; uronium salt; racemization
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Al-Warhi, T.I.; AL-Hazimi, H.M.; El-Faham, A.; Albericio, F. Synthesis of 2-(4,6-Dimethoxy-1,3,5-triazin-2-yloxyimino) Derivatives: Application in Solution Peptide Synthesis. Molecules 2010, 15, 9403-9417.

AMA Style

Al-Warhi TI, AL-Hazimi HM, El-Faham A, Albericio F. Synthesis of 2-(4,6-Dimethoxy-1,3,5-triazin-2-yloxyimino) Derivatives: Application in Solution Peptide Synthesis. Molecules. 2010; 15(12):9403-9417.

Chicago/Turabian Style

Al-Warhi, Tarfah I.; AL-Hazimi, Hassan M.A.; El-Faham, Ayman; Albericio, Fernando. 2010. "Synthesis of 2-(4,6-Dimethoxy-1,3,5-triazin-2-yloxyimino) Derivatives: Application in Solution Peptide Synthesis." Molecules 15, no. 12: 9403-9417.



Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert