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Molecules 2010, 15(12), 9418-9426; doi:10.3390/molecules15129418
Article

Facile and Convenient Synthesis of New Thieno[2,3-b]-Thiophene Derivatives

1,* , 2,†
 and
1
Received: 12 October 2010 / Revised: 15 December 2010 / Accepted: 16 December 2010 / Published: 20 December 2010
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Abstract

A facile and convenient synthesis of bis(2-(1H-benzo[d]imidazol-2(3H)-ylidene)-3-oxopropanenitrile), bis((3-amino-5-(methylthio)-1H-pyrazol-4-yl)methanone) and bis(2-thioxo-1,2-dihydropyrimidine-5-carbonitrile) derivatives incorporating a thieno- [2,3-b]thiophene moiety via versatile, readily accessible diethyl 3,4-dimethylthieno-[2,3-b]thiophene-2,5-dicarboxylate (1) is described.
Keywords: thieno[2,3-b]thiophene; bis-heterocycles; nucleophilic addition; 2-bromo-1-phenylethanone thieno[2,3-b]thiophene; bis-heterocycles; nucleophilic addition; 2-bromo-1-phenylethanone
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Mabkhot, Y.N.; Abd Elshafy Kheder, N.; Al-Majid, A.M. Facile and Convenient Synthesis of New Thieno[2,3-b]-Thiophene Derivatives. Molecules 2010, 15, 9418-9426.

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