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Molecules 2010, 15(11), 8214-8228; doi:10.3390/molecules15118214
Article

Crucial Role of Selenium in the Virucidal Activity of Benzisoselenazol-3(2H)-ones and Related Diselenides

1,* , 1
, 2
 and 1
1 Faculty of Chemistry, Wroclaw University of Technology, Wybrzeze Wyspianskiego 27, 50-370 Wroclaw, Poland 2 Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, R. Weigla 12, 53-114 Wroclaw, Poland
* Author to whom correspondence should be addressed.
Received: 29 October 2010 / Revised: 5 November 2010 / Accepted: 9 November 2010 / Published: 12 November 2010
(This article belongs to the Special Issue Antivirals)
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Abstract

Various N-substituted benzisoselenazol-3(2H)-ones and their non-selenium-containing analogues have been synthesized and tested against selected viruses (HHV-1, EMCV and VSV) to determine the extent to which selenium plays a role in antiviral activity. The data presented here show that the presence of selenium is crucial for the antiviral properties of benzisoselenazol-3(2H)-ones since their isostructural analogues having different groups but lacking selenium either did not show any antiviral activity or their activity was substantially lower. The open-chain analogues of benzisoselenazol-3(2H)-ones—diselenides also exhibited high antiviral activity while selenides and disulfides were completely inactive towards model viruses.
Keywords: organoselenium compounds; organosulfur compounds; isoindolin-1-ones; ebselen; antiviral activity organoselenium compounds; organosulfur compounds; isoindolin-1-ones; ebselen; antiviral activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Pietka-Ottlik, M.; Potaczek, P.; Piasecki, E.; Mlochowski, J. Crucial Role of Selenium in the Virucidal Activity of Benzisoselenazol-3(2H)-ones and Related Diselenides. Molecules 2010, 15, 8214-8228.

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