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Molecules 2010, 15(11), 8214-8228; doi:10.3390/molecules15118214

Crucial Role of Selenium in the Virucidal Activity of Benzisoselenazol-3(2H)-ones and Related Diselenides

1
Faculty of Chemistry, Wroclaw University of Technology, Wybrzeze Wyspianskiego 27, 50-370 Wroclaw, Poland
2
Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, R. Weigla 12, 53-114 Wroclaw, Poland
*
Author to whom correspondence should be addressed.
Received: 29 October 2010 / Revised: 5 November 2010 / Accepted: 9 November 2010 / Published: 12 November 2010
(This article belongs to the Special Issue Antivirals)
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Abstract

Various N-substituted benzisoselenazol-3(2H)-ones and their non-selenium-containing analogues have been synthesized and tested against selected viruses (HHV-1, EMCV and VSV) to determine the extent to which selenium plays a role in antiviral activity. The data presented here show that the presence of selenium is crucial for the antiviral properties of benzisoselenazol-3(2H)-ones since their isostructural analogues having different groups but lacking selenium either did not show any antiviral activity or their activity was substantially lower. The open-chain analogues of benzisoselenazol-3(2H)-ones—diselenides also exhibited high antiviral activity while selenides and disulfides were completely inactive towards model viruses.
Keywords: organoselenium compounds; organosulfur compounds; isoindolin-1-ones; ebselen; antiviral activity organoselenium compounds; organosulfur compounds; isoindolin-1-ones; ebselen; antiviral activity
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Pietka-Ottlik, M.; Potaczek, P.; Piasecki, E.; Mlochowski, J. Crucial Role of Selenium in the Virucidal Activity of Benzisoselenazol-3(2H)-ones and Related Diselenides. Molecules 2010, 15, 8214-8228.

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