Open AccessThis article is
- freely available
Chemical Constituents of the Bark of Dipteryx alata Vogel, an Active Species against Bothrops jararacussu Venom
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Campus "Miguel de Unamuno", Salamanca University, E-37007 Salamanca, Spain
Sorocaba University, UNISO, Rodovia Raposo Tavares km 92.5, 18023-000, Sorocaba, SP, Brazil
Methodist University of Piracicaba, Rodovia do Açúcar km 156, 13400-911, Piracicaba, SP, Brazil
Federal University of Tocantins, Av. NS 15 ALC NO 14, 109 Norte, 77001-090, Porto Nacional, TO, Brazil
* Author to whom correspondence should be addressed.
Received: 25 September 2010; in revised form: 4 November 2010 / Accepted: 10 November 2010 / Published: 12 November 2010
Abstract: The effect of four sub-extracts prepared from the lyophilized hydroalcoholic bark of Dipteryx alata (Leguminosae-Papilionoideae) dissolved in a methanol-water (80:20) mixture through a liquid-liquid partition procedure has been investigated against the neuromuscular blockade of the venom of the snake Bothrops jararacussu. The active CH2Cl2 sub-extract has been extensively analyzed for its chemical constituents, resulting in the isolation of four lupane-type triterpenoids: lupeol (1), lupenone (2), 28-hydroxylup-20(29)-en-3-one (3), betulin (4), nine isoflavonoids: 8-O-methylretusin (5), 7-hydroxy-5,6,4’-trimethoxyisoflavone (6), afrormosin (8), 7-hydroxy-8,3’,4’-trimethoxyisoflavone (9), 7,3’-dihydroxy-8,4’-dimethoxyisoflavone (10), odoratin (11), 7,8,3’-trihydroxy-4’-methoxyisoflavone (13), 7,8,3’-trihydroxy-6,4’-dimethoxyisoflavone (15), dipteryxin (17), one chalcone: isoliquiritigenin (7), one aurone: sulfuretin (14) and three phenolic compounds: vanillic acid (12), vanillin (16), and protocatechuic acid (18). Their chemical structures were elucidated on the basis of spectroscopic analysis, including HRMS, 1D- and 2D-NMR techniques.
Keywords: Dipteryx alata; Leguminosae-Papilionoideae; isoflavone; Bothrops jararacussu; snake venom; neutralization
Article StatisticsClick here to load and display the download statistics.
Notes: Multiple requests from the same IP address are counted as one view.
Cite This Article
MDPI and ACS Style
Puebla, P.; Oshima-Franco, Y.; Franco, L.M.; Santos, M.G.D.; Silva, R.V.; Rubem-Mauro, L.; Feliciano, A.S. Chemical Constituents of the Bark of Dipteryx alata Vogel, an Active Species against Bothrops jararacussu Venom. Molecules 2010, 15, 8193-8204.
Puebla P, Oshima-Franco Y, Franco LM, Santos MGD, Silva RV, Rubem-Mauro L, Feliciano AS. Chemical Constituents of the Bark of Dipteryx alata Vogel, an Active Species against Bothrops jararacussu Venom. Molecules. 2010; 15(11):8193-8204.
Puebla, Pilar; Oshima-Franco, Yoko; Franco, Luiz M.; Santos, Marcio G. Dos; Silva, Renata V. da; Rubem-Mauro, Leandro; Feliciano, Arturo San. 2010. "Chemical Constituents of the Bark of Dipteryx alata Vogel, an Active Species against Bothrops jararacussu Venom." Molecules 15, no. 11: 8193-8204.