Abstract: Six azaphilonoid derivatives, including two new blue fluorescent monapurfluores A (1) and B (2), two known pyridine-containing molecules, monascopyridines C (3) and D (4), and two known monasfluores A (5) and B (6), were isolated and characterized from red mold rice fermented by Monascus purpureus NTU 568. Structural elucidation of new isolates was based on nuclear magnetic resonance (1H- NMR, 13C-NMR, COSY, HMQC, and HMBC) and other spectroscopic analyses. Bioactivity evaluation indicated that 1-6 possessed anti-inflammatory activities with dose-dependent relationships for lipopolysaccharide (LPS)-induced nitric oxide production. Furthermore, 1-4 also showed moderate antiproliferative effects against human laryngeal carcinoma (HEp-2) (IC50 = 14.81~20.06 μg/mL) and human colon adenocarcinoma (WiDr) (IC50 = 12.89~21.14 μg/mL).
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Hsu, Y.-W.; Hsu, L.-C.; Chang, C.-L.; Liang, Y.-H.; Kuo, Y.-H.; Pan, T.-M. New Anti-Inflammatory and Anti-Proliferative Constituents from Fermented Red Mold Rice Monascus purpureus NTU 568. Molecules 2010, 15, 7815-7824.
Hsu Y-W, Hsu L-C, Chang C-L, Liang Y-H, Kuo Y-H, Pan T-M. New Anti-Inflammatory and Anti-Proliferative Constituents from Fermented Red Mold Rice Monascus purpureus NTU 568. Molecules. 2010; 15(11):7815-7824.
Hsu, Ya-Wen; Hsu, Li-Chuan; Chang, Chao-Lin; Liang, Yu-Han; Kuo, Yao-Haur; Pan, Tzu-Ming. 2010. "New Anti-Inflammatory and Anti-Proliferative Constituents from Fermented Red Mold Rice Monascus purpureus NTU 568." Molecules 15, no. 11: 7815-7824.