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Molecules 2010, 15(11), 7815-7824; doi:10.3390/molecules15117815
Article

New Anti-Inflammatory and Anti-Proliferative Constituents from Fermented Red Mold Rice Monascus purpureus NTU 568

1,2, 1,2, 2, 1,2, 2,3,*  and 1,*
Received: 14 October 2010; in revised form: 29 October 2010 / Accepted: 1 November 2010 / Published: 3 November 2010
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Abstract: Six azaphilonoid derivatives, including two new blue fluorescent monapurfluores A (1) and B (2), two known pyridine-containing molecules, monascopyridines C (3) and D (4), and two known monasfluores A (5) and B (6), were isolated and characterized from red mold rice fermented by Monascus purpureus NTU 568. Structural elucidation of new isolates was based on nuclear magnetic resonance (1H- NMR, 13C-NMR, COSY, HMQC, and HMBC) and other spectroscopic analyses. Bioactivity evaluation indicated that 1-6 possessed anti-inflammatory activities with dose-dependent relationships for lipopolysaccharide (LPS)-induced nitric oxide production. Furthermore, 1-4 also showed moderate antiproliferative effects against human laryngeal carcinoma (HEp-2) (IC50 = 14.81~20.06 μg/mL) and human colon adenocarcinoma (WiDr) (IC50 = 12.89~21.14 μg/mL).
Keywords: red mold rice (RMR); Monascus purpureus NTU 568; azaphilonoid derivatives; anti-inflammatory; anti-proliferativered mold rice (RMR); Monascus purpureus NTU 568; azaphilonoid derivatives; anti-inflammatory; anti-proliferative red mold rice (RMR); Monascus purpureus NTU 568; azaphilonoid derivatives; anti-inflammatory; anti-proliferativered mold rice (RMR); Monascus purpureus NTU 568; azaphilonoid derivatives; anti-inflammatory; anti-proliferative
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Hsu, Y.-W.; Hsu, L.-C.; Chang, C.-L.; Liang, Y.-H.; Kuo, Y.-H.; Pan, T.-M. New Anti-Inflammatory and Anti-Proliferative Constituents from Fermented Red Mold Rice Monascus purpureus NTU 568. Molecules 2010, 15, 7815-7824.

AMA Style

Hsu Y-W, Hsu L-C, Chang C-L, Liang Y-H, Kuo Y-H, Pan T-M. New Anti-Inflammatory and Anti-Proliferative Constituents from Fermented Red Mold Rice Monascus purpureus NTU 568. Molecules. 2010; 15(11):7815-7824.

Chicago/Turabian Style

Hsu, Ya-Wen; Hsu, Li-Chuan; Chang, Chao-Lin; Liang, Yu-Han; Kuo, Yao-Haur; Pan, Tzu-Ming. 2010. "New Anti-Inflammatory and Anti-Proliferative Constituents from Fermented Red Mold Rice Monascus purpureus NTU 568." Molecules 15, no. 11: 7815-7824.


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