Next Article in Journal
Composition and Antimicrobial Activities of Lippia multiflora Moldenke, Mentha x piperita L. and Ocimum basilicum L. Essential Oils and Their Major Monoterpene Alcohols Alone and in Combination
Previous Article in Journal
Nutraceutical Antioxidants as Novel Neuroprotective Agents
Molecules 2010, 15(11), 7815-7824; doi:10.3390/molecules15117815
Article

New Anti-Inflammatory and Anti-Proliferative Constituents from Fermented Red Mold Rice Monascus purpureus NTU 568

1,2, 1,2, 2, 1,2, 2,3,*  and 1,*
1 Department of Biochemical Science and Technology, National Taiwan University, Taipei, Taiwan 10617, Taiwan 2 Division of Herbal Drugs and Natural Products, National Research Institute of Chinese Medicine, Taipei, Taiwan 11221, Taiwan 3 Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan 40402, Taiwan
* Authors to whom correspondence should be addressed.
Received: 14 October 2010 / Revised: 29 October 2010 / Accepted: 1 November 2010 / Published: 3 November 2010
Download PDF [277 KB, uploaded 18 June 2014]

Abstract

Six azaphilonoid derivatives, including two new blue fluorescent monapurfluores A (1) and B (2), two known pyridine-containing molecules, monascopyridines C (3) and D (4), and two known monasfluores A (5) and B (6), were isolated and characterized from red mold rice fermented by Monascus purpureus NTU 568. Structural elucidation of new isolates was based on nuclear magnetic resonance (1H- NMR, 13C-NMR, COSY, HMQC, and HMBC) and other spectroscopic analyses. Bioactivity evaluation indicated that 1-6 possessed anti-inflammatory activities with dose-dependent relationships for lipopolysaccharide (LPS)-induced nitric oxide production. Furthermore, 1-4 also showed moderate antiproliferative effects against human laryngeal carcinoma (HEp-2) (IC50 = 14.81~20.06 μg/mL) and human colon adenocarcinoma (WiDr) (IC50 = 12.89~21.14 μg/mL).
Keywords: red mold rice (RMR); Monascus purpureus NTU 568; azaphilonoid derivatives; anti-inflammatory; anti-proliferativered mold rice (RMR); Monascus purpureus NTU 568; azaphilonoid derivatives; anti-inflammatory; anti-proliferative red mold rice (RMR); Monascus purpureus NTU 568; azaphilonoid derivatives; anti-inflammatory; anti-proliferativered mold rice (RMR); Monascus purpureus NTU 568; azaphilonoid derivatives; anti-inflammatory; anti-proliferative
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Export to BibTeX |
EndNote


MDPI and ACS Style

Hsu, Y.-W.; Hsu, L.-C.; Chang, C.-L.; Liang, Y.-H.; Kuo, Y.-H.; Pan, T.-M. New Anti-Inflammatory and Anti-Proliferative Constituents from Fermented Red Mold Rice Monascus purpureus NTU 568. Molecules 2010, 15, 7815-7824.

View more citation formats

Related Articles

Article Metrics

Comments

Citing Articles

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert