Molecules 2010, 15(11), 7815-7824; doi:10.3390/molecules15117815
Article

New Anti-Inflammatory and Anti-Proliferative Constituents from Fermented Red Mold Rice Monascus purpureus NTU 568

1 Department of Biochemical Science and Technology, National Taiwan University, Taipei, Taiwan 10617, Taiwan 2 Division of Herbal Drugs and Natural Products, National Research Institute of Chinese Medicine, Taipei, Taiwan 11221, Taiwan 3 Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan 40402, Taiwan
* Authors to whom correspondence should be addressed.
Received: 14 October 2010; in revised form: 29 October 2010 / Accepted: 1 November 2010 / Published: 3 November 2010
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Abstract: Six azaphilonoid derivatives, including two new blue fluorescent monapurfluores A (1) and B (2), two known pyridine-containing molecules, monascopyridines C (3) and D (4), and two known monasfluores A (5) and B (6), were isolated and characterized from red mold rice fermented by Monascus purpureus NTU 568. Structural elucidation of new isolates was based on nuclear magnetic resonance (1H- NMR, 13C-NMR, COSY, HMQC, and HMBC) and other spectroscopic analyses. Bioactivity evaluation indicated that 1-6 possessed anti-inflammatory activities with dose-dependent relationships for lipopolysaccharide (LPS)-induced nitric oxide production. Furthermore, 1-4 also showed moderate antiproliferative effects against human laryngeal carcinoma (HEp-2) (IC50 = 14.81~20.06 μg/mL) and human colon adenocarcinoma (WiDr) (IC50 = 12.89~21.14 μg/mL).
Keywords: red mold rice (RMR); Monascus purpureus NTU 568; azaphilonoid derivatives; anti-inflammatory; anti-proliferativered mold rice (RMR); Monascus purpureus NTU 568; azaphilonoid derivatives; anti-inflammatory; anti-proliferative

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MDPI and ACS Style

Hsu, Y.-W.; Hsu, L.-C.; Chang, C.-L.; Liang, Y.-H.; Kuo, Y.-H.; Pan, T.-M. New Anti-Inflammatory and Anti-Proliferative Constituents from Fermented Red Mold Rice Monascus purpureus NTU 568. Molecules 2010, 15, 7815-7824.

AMA Style

Hsu Y-W, Hsu L-C, Chang C-L, Liang Y-H, Kuo Y-H, Pan T-M. New Anti-Inflammatory and Anti-Proliferative Constituents from Fermented Red Mold Rice Monascus purpureus NTU 568. Molecules. 2010; 15(11):7815-7824.

Chicago/Turabian Style

Hsu, Ya-Wen; Hsu, Li-Chuan; Chang, Chao-Lin; Liang, Yu-Han; Kuo, Yao-Haur; Pan, Tzu-Ming. 2010. "New Anti-Inflammatory and Anti-Proliferative Constituents from Fermented Red Mold Rice Monascus purpureus NTU 568." Molecules 15, no. 11: 7815-7824.

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