Next Article in Journal
Prenylated Xanthones from the Bark of Garcinia xanthochymus and Their 1,1-Diphenyl-2-picrylhydrazyl (DPPH) Radical Scavenging Activities
Previous Article in Journal
The Pharmacological Effects of Morroniside and Loganin Isolated from Liuweidihuang Wan, on MC3T3-E1 Cells
Article Menu

Article Versions

Export Article

Open AccessArticle
Molecules 2010, 15(10), 7415-7422; doi:10.3390/molecules15107415

Evaluation on Anti-hepatitis Viral Activity of Vitis vinifer L

1
College of Public Health, Xinjiang Medical University, Urumqi, 830011, China
2
Xinjiang Key Laboratory for Research and Development of Uighur Medicine, Institute of Materia Medica of Xinjiang, Urumqi, 830002, China
3
Nantong Center for Disease Control and Prevention, Nantong, 226007, China
*
Author to whom correspondence should be addressed.
Received: 20 August 2010 / Revised: 15 October 2010 / Accepted: 19 October 2010 / Published: 22 October 2010
Download PDF [199 KB, uploaded 18 June 2014]

Abstract

Suosuo grape (Vitis vinifer L) is traditionally used as a therapeutic agent for measles and hepatitis by the ethnic Uighurs. This work aimed to investigate the anti-HBV effect of total triterpene (VTT), total flavonoids (VTF) and total polysaccharides (VTP) from Suosuo grape, and their synergistic effects were also tested. The viral antigens of cellular secretion, HBsAg and HBeAg, were determined by enzyme linked immunosorbent assay (ELISA).The quantity of HBV-DNA released in the supernatant was assayed by real-time PCR. It was found that it effectively suppressed the secretion of HBsAg and HBeAg from HepG2.2.15 cells in a dose-dependent manner, as well as the HBV DNA. The results of orthogonal design experiment showed that the combination of VTT 20 μg/mL, VTF 50 μg/mL and VTP 50 μg/mL had the best optimistic inhibitory effects on HBeAg secretion.
Keywords: Vitis vinifer L; anti-hepatitis viral activity; orthogonal design Vitis vinifer L; anti-hepatitis viral activity; orthogonal design
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Liu, T.; Zhao, J.; Li, H.; Ma, L. Evaluation on Anti-hepatitis Viral Activity of Vitis vinifer L. Molecules 2010, 15, 7415-7422.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top