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Molecules 2010, 15(10), 7438-7449; doi:10.3390/molecules15107438

Prenylated Xanthones from the Bark of Garcinia xanthochymus and Their 1,1-Diphenyl-2-picrylhydrazyl (DPPH) Radical Scavenging Activities

1
Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, Central China Normal University, Wuhan 430079, China
2
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
3
College of Chemistry and Material Sciences, South Central University for Nationalities, Wuhan 430074, China
4
Laboratory for Natural Product Chemistry, College of Pharmacy, South Central University for Nationalities, Wuhan 430074, China
*
Authors to whom correspondence should be addressed.
Received: 25 September 2010 / Revised: 7 October 2010 / Accepted: 11 October 2010 / Published: 22 October 2010
(This article belongs to the Section Natural Products)
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Abstract

Garcinia xanthochymus has been widely used in traditional Chinese medicine for expelling worms and removing food toxins. Bioassay-guided fractionation of an EtOAc-soluble extract of G. xanthochymus stem bark led to the isolation of six new xanthones. Their structures were elucidated by spectroscopic methods, especially 2D-NMR techniques. Free-radical-scavenging activities of the isolated compounds were elucidated through DPPH method. Most of the isolated compounds showed considerable free radical scavenging activity on DPPH assay. Compound 1 exhibited effective antioxidant scavenging activity against DPPH radical with an IC50 value of 19.64 μM, and compound 6 showed the lowest activity among all the tested molecules, with an IC50 value of 66.88 μM. These findings support the notion that the plant genus Garcinia is a good source of bioactive compounds.
Keywords: Xanthones; Garcinia xanthochymus; DPPH radical scavenging activity Xanthones; Garcinia xanthochymus; DPPH radical scavenging activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Chen, Y.; Fan, H.; Yang, G.-Z.; Jiang, Y.; Zhong, F.-F.; He, H.-W. Prenylated Xanthones from the Bark of Garcinia xanthochymus and Their 1,1-Diphenyl-2-picrylhydrazyl (DPPH) Radical Scavenging Activities. Molecules 2010, 15, 7438-7449.

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