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Molecules 2010, 15(10), 7438-7449; doi:10.3390/molecules15107438
Article

Prenylated Xanthones from the Bark of Garcinia xanthochymus and Their 1,1-Diphenyl-2-picrylhydrazyl (DPPH) Radical Scavenging Activities

1,2,3, 4, 1,2,4,* , 4, 4 and 1,2,*
Received: 25 September 2010; in revised form: 7 October 2010 / Accepted: 11 October 2010 / Published: 22 October 2010
(This article belongs to the Section Metabolites)
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Abstract: Garcinia xanthochymus has been widely used in traditional Chinese medicine for expelling worms and removing food toxins. Bioassay-guided fractionation of an EtOAc-soluble extract of G. xanthochymus stem bark led to the isolation of six new xanthones. Their structures were elucidated by spectroscopic methods, especially 2D-NMR techniques. Free-radical-scavenging activities of the isolated compounds were elucidated through DPPH method. Most of the isolated compounds showed considerable free radical scavenging activity on DPPH assay. Compound 1 exhibited effective antioxidant scavenging activity against DPPH radical with an IC50 value of 19.64 μM, and compound 6 showed the lowest activity among all the tested molecules, with an IC50 value of 66.88 μM. These findings support the notion that the plant genus Garcinia is a good source of bioactive compounds.
Keywords: Xanthones; Garcinia xanthochymus; DPPH radical scavenging activity Xanthones; Garcinia xanthochymus; DPPH radical scavenging activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Chen, Y.; Fan, H.; Yang, G.-Z.; Jiang, Y.; Zhong, F.-F.; He, H.-W. Prenylated Xanthones from the Bark of Garcinia xanthochymus and Their 1,1-Diphenyl-2-picrylhydrazyl (DPPH) Radical Scavenging Activities. Molecules 2010, 15, 7438-7449.

AMA Style

Chen Y, Fan H, Yang G-Z, Jiang Y, Zhong F-F, He H-W. Prenylated Xanthones from the Bark of Garcinia xanthochymus and Their 1,1-Diphenyl-2-picrylhydrazyl (DPPH) Radical Scavenging Activities. Molecules. 2010; 15(10):7438-7449.

Chicago/Turabian Style

Chen, Yu; Fan, Hua; Yang, Guang-zhong; Jiang, Yan; Zhong, Fang-fang; He, Hong-wu. 2010. "Prenylated Xanthones from the Bark of Garcinia xanthochymus and Their 1,1-Diphenyl-2-picrylhydrazyl (DPPH) Radical Scavenging Activities." Molecules 15, no. 10: 7438-7449.



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