Molecules 2010, 15(1), 83-92; doi:10.3390/molecules15010083
Article

Transition-Metal-Free Highly Efficient Aerobic Oxidation of Sulfides to Sulfoxides under Mild Conditions

1 State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, No.158-139, Zhongshan Road, Dalian 116012, China 2 School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
* Author to whom correspondence should be addressed.
Received: 30 November 2009; in revised form: 17 December 2009 / Accepted: 23 December 2009 / Published: 28 December 2009
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Abstract: A highly efficient transition-metal-free catalytic system Br2/NaNO2/H2O has been developed for a robust and economic acid-free aerobic oxidation of sulfides. It is noteworthy that the sulfide function reacts under mild conditions without over-oxidation to sulfone. The role of NaNO2as an efficient NO equivalent for the activation of molecular oxygen was identified. Under the optimal conditions, a broad range of sulfide substrates were converted into their corresponding sulfoxides in high yields by molecular oxygen. The present catalytic system utilizes cheap and readily available agents as the catalysts, exhibits high selectivity for sulfoxide products and releases only innocuous water as the by-products.
Keywords: aerobic oxidation; sulfids; Br2; NaNO2; molecular oxygen

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MDPI and ACS Style

Zhang, H.; Chen, C.; Liu, R.; Xu, Q.; Zhao, W. Transition-Metal-Free Highly Efficient Aerobic Oxidation of Sulfides to Sulfoxides under Mild Conditions. Molecules 2010, 15, 83-92.

AMA Style

Zhang H, Chen C, Liu R, Xu Q, Zhao W. Transition-Metal-Free Highly Efficient Aerobic Oxidation of Sulfides to Sulfoxides under Mild Conditions. Molecules. 2010; 15(1):83-92.

Chicago/Turabian Style

Zhang, Hua; Chen, Chunyu; Liu, Renhua; Xu, Qiang; Zhao, Weiqie. 2010. "Transition-Metal-Free Highly Efficient Aerobic Oxidation of Sulfides to Sulfoxides under Mild Conditions." Molecules 15, no. 1: 83-92.

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