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Molecules 2010, 15(1), 68-82; doi:10.3390/molecules15010068

An Efficient, Mild and Solvent-Free Synthesis of Benzene Ring Acylated Harmalines

H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
Author to whom correspondence should be addressed.
Received: 19 October 2009 / Revised: 24 November 2009 / Accepted: 27 November 2009 / Published: 28 December 2009
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A facile synthesis of a series of benzene ring acylated analogues of harmaline has been achieved by Friedel-Crafts acylation under solvent-free conditions at room temperature using acyl halides/acid anhydrides and AlCl3. The reaction afforded 10- and 12-acyl analogues of harmaline in good yield, along with minor quantities of N-acyl-tryptamines and 8-acyl analogues of N-acyltryptamines.
Keywords: β-carboline; acylharmaline; Friedel-Crafts acylation; solvent-free reaction β-carboline; acylharmaline; Friedel-Crafts acylation; solvent-free reaction

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Begum, S.; Zubair, F.; Nawazish Ali, S.; Shaheen Siddiqui, B. An Efficient, Mild and Solvent-Free Synthesis of Benzene Ring Acylated Harmalines. Molecules 2010, 15, 68-82.

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