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An Efficient, Mild and Solvent-Free Synthesis of Benzene Ring Acylated Harmalines
H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
* Author to whom correspondence should be addressed.
Received: 19 October 2009; in revised form: 24 November 2009 / Accepted: 27 November 2009 / Published: 28 December 2009
Abstract: A facile synthesis of a series of benzene ring acylated analogues of harmaline has been achieved by Friedel-Crafts acylation under solvent-free conditions at room temperature using acyl halides/acid anhydrides and AlCl3. The reaction afforded 10- and 12-acyl analogues of harmaline in good yield, along with minor quantities of N-acyl-tryptamines and 8-acyl analogues of N-acyltryptamines.
Keywords: β-carboline; acylharmaline; Friedel-Crafts acylation; solvent-free reaction
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Begum, S.; Zubair, F.; Nawazish Ali, S.; Shaheen Siddiqui, B. An Efficient, Mild and Solvent-Free Synthesis of Benzene Ring Acylated Harmalines. Molecules 2010, 15, 68-82.
Begum S, Zubair F, Nawazish Ali S, Shaheen Siddiqui B. An Efficient, Mild and Solvent-Free Synthesis of Benzene Ring Acylated Harmalines. Molecules. 2010; 15(1):68-82.
Begum, Sabira; Zubair, Farhat; Nawazish Ali, Syed; Shaheen Siddiqui, Bina. 2010. "An Efficient, Mild and Solvent-Free Synthesis of Benzene Ring Acylated Harmalines." Molecules 15, no. 1: 68-82.