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Molecules 2010, 15(1), 68-82; doi:10.3390/molecules15010068
Article

An Efficient, Mild and Solvent-Free Synthesis of Benzene Ring Acylated Harmalines

* ,
,
 and
H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
* Author to whom correspondence should be addressed.
Received: 19 October 2009 / Revised: 24 November 2009 / Accepted: 27 November 2009 / Published: 28 December 2009
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Abstract

A facile synthesis of a series of benzene ring acylated analogues of harmaline has been achieved by Friedel-Crafts acylation under solvent-free conditions at room temperature using acyl halides/acid anhydrides and AlCl3. The reaction afforded 10- and 12-acyl analogues of harmaline in good yield, along with minor quantities of N-acyl-tryptamines and 8-acyl analogues of N-acyltryptamines.
Keywords: β-carboline; acylharmaline; Friedel-Crafts acylation; solvent-free reaction β-carboline; acylharmaline; Friedel-Crafts acylation; solvent-free reaction
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Begum, S.; Zubair, F.; Nawazish Ali, S.; Shaheen Siddiqui, B. An Efficient, Mild and Solvent-Free Synthesis of Benzene Ring Acylated Harmalines. Molecules 2010, 15, 68-82.

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