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Molecules 2010, 15(1), 68-82; doi:10.3390/molecules15010068
Article

An Efficient, Mild and Solvent-Free Synthesis of Benzene Ring Acylated Harmalines

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Received: 19 October 2009; in revised form: 24 November 2009 / Accepted: 27 November 2009 / Published: 28 December 2009
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Abstract: A facile synthesis of a series of benzene ring acylated analogues of harmaline has been achieved by Friedel-Crafts acylation under solvent-free conditions at room temperature using acyl halides/acid anhydrides and AlCl3. The reaction afforded 10- and 12-acyl analogues of harmaline in good yield, along with minor quantities of N-acyl-tryptamines and 8-acyl analogues of N-acyltryptamines.
Keywords: β-carboline; acylharmaline; Friedel-Crafts acylation; solvent-free reaction β-carboline; acylharmaline; Friedel-Crafts acylation; solvent-free reaction
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Begum, S.; Zubair, F.; Nawazish Ali, S.; Shaheen Siddiqui, B. An Efficient, Mild and Solvent-Free Synthesis of Benzene Ring Acylated Harmalines. Molecules 2010, 15, 68-82.

AMA Style

Begum S, Zubair F, Nawazish Ali S, Shaheen Siddiqui B. An Efficient, Mild and Solvent-Free Synthesis of Benzene Ring Acylated Harmalines. Molecules. 2010; 15(1):68-82.

Chicago/Turabian Style

Begum, Sabira; Zubair, Farhat; Nawazish Ali, Syed; Shaheen Siddiqui, Bina. 2010. "An Efficient, Mild and Solvent-Free Synthesis of Benzene Ring Acylated Harmalines." Molecules 15, no. 1: 68-82.


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