Synthesis and in Vitro Cytotoxic Activity of Compounds with Pro-Apoptotic Potential

doi:10.3390/molecules15010012

This article is

freely available
re-usable

Molecules 2010, 15(1), 12-26; doi:10.3390/molecules15010012

Article

Synthesis and in Vitro Cytotoxic Activity of Compounds with Pro-Apoptotic Potential

Gisell Apicela Soares¹, Renata Barbosa de Oliveira^1,2, Saulo Fernandes de Andrade², Ricardo José Alves², Carlos Leomar Zani¹ and Elaine Maria De Souza-Fagundes^1,3,*

¹ Laboratório de Química de Produtos Naturais, Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz (FIOCRUZ), Av. Augusto de Lima 1715, Belo Horizonte, MG, 30190-002, Brazil ² Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais (UFMG), Avenida Antônio Carlos 6627, Belo Horizonte, MG, 31.270-901, Brazil ³ Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Avenida Antônio Carlos 6627, Belo Horizonte, MG, 31.270-901, Brazil

* Author to whom correspondence should be addressed.

Received: 24 November 2009; in revised form: 12 December 2009 / Accepted: 18 December 2009 / Published: 24 December 2009

Download PDF Full-Text [389 KB, uploaded 24 December 2009 10:20 CET]

Abstract: In our search for new anticancer therapies, some compounds synthesized in our lab were selected and their potential cytotoxic activity was evaluated in vitro against two cancer cells lines including a solid tumor (UACC-62, melanoma) and a human lymphoma (JURKAT). Compounds showing cytotoxic activity were subjected to an apoptosis assay. Two compounds showed promising results.

Keywords: carbohydrates; furan derivatives; cytotoxic activity; anti-tumor; apoptosis

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Apicela Soares, G.; Barbosa de Oliveira, R.; Fernandes de Andrade, S.; Alves, R.J.; Leomar Zani, C.; De Souza-Fagundes, E.M. Synthesis and in Vitro Cytotoxic Activity of Compounds with Pro-Apoptotic Potential. Molecules 2010, 15, 12-26.

AMA Style

Apicela Soares G, Barbosa de Oliveira R, Fernandes de Andrade S, Alves RJ, Leomar Zani C, De Souza-Fagundes EM. Synthesis and in Vitro Cytotoxic Activity of Compounds with Pro-Apoptotic Potential. Molecules. 2010; 15(1):12-26.

Chicago/Turabian Style

Apicela Soares, Gisell; Barbosa de Oliveira, Renata; Fernandes de Andrade, Saulo; Alves, Ricardo José; Leomar Zani, Carlos; De Souza-Fagundes, Elaine Maria. 2010. "Synthesis and in Vitro Cytotoxic Activity of Compounds with Pro-Apoptotic Potential." Molecules 15, no. 1: 12-26.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert