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Molecules 2009, 14(8), 2918-2926; doi:10.3390/molecules14082918

Cross-Cyclotrimerization with Two Nitriles as a Synthetic Pathway to Unsymmetrically 3,3’-Disubstituted bis(Tetrahydroisoquinolines)

Department of Organic and Nuclear Chemistry, and Center for Structural and Synthetic Application of Transition Metal Complexes, Faculty of Science, Charles University in Prague, Hlavova 8, 128 43 Praha 2, Czech Republic
Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nám. 2, 166 10 Praha 6, Czech Republic
Author to whom correspondence should be addressed.
Received: 10 July 2009 / Revised: 31 July 2009 / Accepted: 3 August 2009 / Published: 10 August 2009
(This article belongs to the Special Issue Microwave Assisted Synthesis)
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Microwave assisted CpCo(CO)2 catalyzed cross-cyclotrimerizations of 1,7,9,15-hexadecatetrayne with two different nitriles to give unsymmetrically substituted bis(tetrahydroisoquinolines) was studied. The reaction proceeded with a range of alkyl and aryl nitriles with reasonable isolated yields.
Keywords: cyclotrimerization; cobalt; microwave heating; pyridines cyclotrimerization; cobalt; microwave heating; pyridines

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Kadlčíková, A.; Kotora, M. Cross-Cyclotrimerization with Two Nitriles as a Synthetic Pathway to Unsymmetrically 3,3’-Disubstituted bis(Tetrahydroisoquinolines). Molecules 2009, 14, 2918-2926.

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