Cross-Cyclotrimerization with Two Nitriles as a Synthetic Pathway to Unsymmetrically 3,3’-Disubstituted bis(Tetrahydroisoquinolines)

doi:10.3390/molecules14082918

This article is

freely available
re-usable

Molecules 2009, 14(8), 2918-2926; doi:10.3390/molecules14082918

Article

Cross-Cyclotrimerization with Two Nitriles as a Synthetic Pathway to Unsymmetrically 3,3’-Disubstituted bis(Tetrahydroisoquinolines)

Aneta Kadlčíková¹ and Martin Kotora^1,2,*

¹ Department of Organic and Nuclear Chemistry, and Center for Structural and Synthetic Application of Transition Metal Complexes, Faculty of Science, Charles University in Prague, Hlavova 8, 128 43 Praha 2, Czech Republic ² Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nám. 2, 166 10 Praha 6, Czech Republic

* Author to whom correspondence should be addressed.

Received: 10 July 2009; in revised form: 31 July 2009 / Accepted: 3 August 2009 / Published: 10 August 2009

(This article belongs to the Special Issue Microwave Assisted Synthesis)

Download PDF Full-Text [233 KB, uploaded 10 August 2009 01:16 CEST]

Abstract: Microwave assisted CpCo(CO)₂ catalyzed cross-cyclotrimerizations of 1,7,9,15-hexadecatetrayne with two different nitriles to give unsymmetrically substituted bis(tetrahydroisoquinolines) was studied. The reaction proceeded with a range of alkyl and aryl nitriles with reasonable isolated yields.

Keywords: cyclotrimerization; cobalt; microwave heating; pyridines

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Kadlčíková, A.; Kotora, M. Cross-Cyclotrimerization with Two Nitriles as a Synthetic Pathway to Unsymmetrically 3,3’-Disubstituted bis(Tetrahydroisoquinolines). Molecules 2009, 14, 2918-2926.

AMA Style

Kadlčíková A, Kotora M. Cross-Cyclotrimerization with Two Nitriles as a Synthetic Pathway to Unsymmetrically 3,3’-Disubstituted bis(Tetrahydroisoquinolines). Molecules. 2009; 14(8):2918-2926.

Chicago/Turabian Style

Kadlčíková, Aneta; Kotora, Martin. 2009. "Cross-Cyclotrimerization with Two Nitriles as a Synthetic Pathway to Unsymmetrically 3,3’-Disubstituted bis(Tetrahydroisoquinolines)." Molecules 14, no. 8: 2918-2926.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert