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Inhibitory Effects of Morinda officinalis Extract on Bone Loss in Ovariectomized Rats
Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
Academy of Integrative Medicine, Fujian College of Traditional Chinese Medicine, Fujian 350108, China
* Authors to whom correspondence should be addressed.
Received: 29 April 2009; in revised form: 2 June 2009 / Accepted: 5 June 2009 / Published: 8 June 2009
Abstract: The present study was undertaken to investigate the protective effects of ethanol extract from the root of Morinda Officinalis (RMO) on ovariectomy-induced bone loss. Administration of RMO extract increased trabecular bone mineral content and bone mineral density of tibia, improved the levels of phosphorus (P), calcium (Ca) and OPG, decreased the levels of DPD/Cr, TRAP, ACTH and corticosterone, but did not reverse the levels of ALP, TNF-α and IL-6 in serum of ovariectomized rats. These findings demonstrated that RMO extract reduced bone loss in ovariectomized rats, probably via the inhibition of bone resorption, but was not involved with bone formation. Anthraquinones and polysaccharides from Morinda officinals could be responsible for their antiosteoporotic activity, and the action mechanism of these constituents needs to be further studied. Therefore, RMO has the potential to develop a clinically useful antiosteoporotic agent.
Keywords: Morinda officinalis; ovariectomy; osteoporosis; serum biochemistry; bone mineral density
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MDPI and ACS Style
Li, N.; Qin, L.-P.; Han, T.; Wu, Y.-B.; Zhang, Q.-Y.; Zhang, H. Inhibitory Effects of Morinda officinalis Extract on Bone Loss in Ovariectomized Rats. Molecules 2009, 14, 2049-2061.
Li N, Qin L-P, Han T, Wu Y-B, Zhang Q-Y, Zhang H. Inhibitory Effects of Morinda officinalis Extract on Bone Loss in Ovariectomized Rats. Molecules. 2009; 14(6):2049-2061.
Li, Nan; Qin, Lu-Ping; Han, Ting; Wu, Yan-Bin; Zhang, Qiao-Yan; Zhang, Hong. 2009. "Inhibitory Effects of Morinda officinalis Extract on Bone Loss in Ovariectomized Rats." Molecules 14, no. 6: 2049-2061.