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Molecules 2009, 14(3), 1145-1159; doi:10.3390/molecules14031145
Article

Ring-substituted 4-Hydroxy-1H-quinolin-2-ones: Preparation and Biological Activity

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Received: 4 February 2009; in revised form: 3 March 2009 / Accepted: 11 March 2009 / Published: 13 March 2009
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Abstract: In the study, a series of twelve ring-substituted 4-hydroxy-1H-quinolin-2-one derivatives were prepared. The procedures for synthesis of the compounds are presented. The compounds were analyzed using RP-HPLC to determine lipophilicity and tested for their photosynthesis-inhibiting activity using spinach (Spinacia oleracea L.) chloroplasts. All the synthesized compounds were also evaluated for antifungal activity using in vitro screening with eight fungal strains. For all the compounds, the relationships between the lipophilicity and the chemical structure of the studied compounds are discussed, as well as their structure-activity relationships (SAR).
Keywords: Quinolinone derivatives; Lipophilicity; OER inhibition; Spinach chloroplasts; In vitro antifungal activity; Structure-activity relationships Quinolinone derivatives; Lipophilicity; OER inhibition; Spinach chloroplasts; In vitro antifungal activity; Structure-activity relationships
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Jampilek, J.; Musiol, R.; Pesko, M.; Kralova, K.; Vejsova, M.; Carroll, J.; Coffey, A.; Finster, J.; Tabak, D.; Niedbala, H.; Kozik, V.; Polanski, J.; Csollei, J.; Dohnal, J. Ring-substituted 4-Hydroxy-1H-quinolin-2-ones: Preparation and Biological Activity. Molecules 2009, 14, 1145-1159.

AMA Style

Jampilek J, Musiol R, Pesko M, Kralova K, Vejsova M, Carroll J, Coffey A, Finster J, Tabak D, Niedbala H, Kozik V, Polanski J, Csollei J, Dohnal J. Ring-substituted 4-Hydroxy-1H-quinolin-2-ones: Preparation and Biological Activity. Molecules. 2009; 14(3):1145-1159.

Chicago/Turabian Style

Jampilek, Josef; Musiol, Robert; Pesko, Matus; Kralova, Katarina; Vejsova, Marcela; Carroll, James; Coffey, Aidan; Finster, Jacek; Tabak, Dominik; Niedbala, Halina; Kozik, Violetta; Polanski, Jaroslaw; Csollei, Jozef; Dohnal, Jiri. 2009. "Ring-substituted 4-Hydroxy-1H-quinolin-2-ones: Preparation and Biological Activity." Molecules 14, no. 3: 1145-1159.



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