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Molecules 2009, 14(3), 1098-1110; doi:10.3390/molecules14031098

Polyphenols with Antiulcerogenic Action from Aqueous Decoction of Mango Leaves (Mangifera indica L.)

1 -Pharmacos and Drugs Department, Pharmaceutical Sciences Faculty, São Paulo State University-UNESP, c.p.355, Zip Code: 14801-902, UNESP, Araraquara, SP, Brazil 2 Physiology Department, Biosciences Institute, São Paulo State University-UNESP, c.p. 510, Zip Code: 18618-000, Botucatu, SP, Brazil 3 Physiology and Biophysics Department, Biology Institute, Campinas State University-UNICAMP, c.p. 6109, Zip Code: 13083-970, Campinas, SP, Brazil 4 Organic Chemistry Department, Chemistry Institute, São Paulo State University-UNESP, c.p. 355, Zip Code: 14800-900, UNESP, Araraquara, SP, Brazil
* Author to whom correspondence should be addressed.
Received: 1 January 2009 / Revised: 12 January 2009 / Accepted: 22 January 2009 / Published: 10 March 2009
(This article belongs to the Special Issue Phenolics and Polyphenolics)
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This study was designed to determine the gastroprotective effect of a Mangifera indica leaf decoction (AD), on different experimental models in rodents. The administration of AD up to a dose of 5 g/kg (p.o.) did not produce any signs or symptoms of toxicity in the treated animals, while significantly decreasing the severity of gastric damage induced by several gastroprotective models. Oral pre-treatment with AD (250, 500 or 1000 mg/kg) in mice and rats with gastric lesions induced by HCl/ethanol, absolute ethanol, non-steroidal anti-inflammatory drug (NSAID) or stress-induced gastric lesions resulted in a significant decrease of said lesions. Phytochemical analyses of AD composition demonstrated the presence of bioactive phenolic compounds that represent 57.3% of total phenolic content in this extract. Two main phenolic compounds were isolated, specifically mangiferin (C-glucopyranoside of 1,3,6,7-tetrahydroxyxanthone) and C-glucosyl-benzophenone (3-C-β-D-glucopyranosyl-4’,2,4,6-tetrahydroxybenzophenone). These findings indicate the potential gastroprotective properties of aqueous decoction from M. indica leaves.
Keywords: Mangifera indica; Antiulcer gastric; Mangiferin; Benzophenone; Phenolic compounds Mangifera indica; Antiulcer gastric; Mangiferin; Benzophenone; Phenolic compounds
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Severi, J.A.; Lima, Z.P.; Kushima, H.; Monteiro Souza Brito, A.R.; Campaner dos Santos, L.; Vilegas, W.; Hiruma-Lima, C.A. Polyphenols with Antiulcerogenic Action from Aqueous Decoction of Mango Leaves (Mangifera indica L.). Molecules 2009, 14, 1098-1110.

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