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Polyphenols with Antiulcerogenic Action from Aqueous Decoction of Mango Leaves (Mangifera indica L.)
-Pharmacos and Drugs Department, Pharmaceutical Sciences Faculty, São Paulo State University-UNESP, c.p.355, Zip Code: 14801-902, UNESP, Araraquara, SP, Brazil
Physiology Department, Biosciences Institute, São Paulo State University-UNESP, c.p. 510, Zip Code: 18618-000, Botucatu, SP, Brazil
Physiology and Biophysics Department, Biology Institute, Campinas State University-UNICAMP, c.p. 6109, Zip Code: 13083-970, Campinas, SP, Brazil
Organic Chemistry Department, Chemistry Institute, São Paulo State University-UNESP, c.p. 355, Zip Code: 14800-900, UNESP, Araraquara, SP, Brazil
* Author to whom correspondence should be addressed.
Received: 1 January 2009; in revised form: 12 January 2009 / Accepted: 22 January 2009 / Published: 10 March 2009
Abstract: This study was designed to determine the gastroprotective effect of a Mangifera indica leaf decoction (AD), on different experimental models in rodents. The administration of AD up to a dose of 5 g/kg (p.o.) did not produce any signs or symptoms of toxicity in the treated animals, while significantly decreasing the severity of gastric damage induced by several gastroprotective models. Oral pre-treatment with AD (250, 500 or 1000 mg/kg) in mice and rats with gastric lesions induced by HCl/ethanol, absolute ethanol, non-steroidal anti-inflammatory drug (NSAID) or stress-induced gastric lesions resulted in a significant decrease of said lesions. Phytochemical analyses of AD composition demonstrated the presence of bioactive phenolic compounds that represent 57.3% of total phenolic content in this extract. Two main phenolic compounds were isolated, specifically mangiferin (C-glucopyranoside of 1,3,6,7-tetrahydroxyxanthone) and C-glucosyl-benzophenone (3-C-β-D-glucopyranosyl-4’,2,4,6-tetrahydroxybenzophenone). These findings indicate the potential gastroprotective properties of aqueous decoction from M. indica leaves.
Keywords: Mangifera indica; Antiulcer gastric; Mangiferin; Benzophenone; Phenolic compounds
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Severi, J.A.; Lima, Z.P.; Kushima, H.; Monteiro Souza Brito, A.R.; Campaner dos Santos, L.; Vilegas, W.; Hiruma-Lima, C.A. Polyphenols with Antiulcerogenic Action from Aqueous Decoction of Mango Leaves (Mangifera indica L.). Molecules 2009, 14, 1098-1110.
Severi JA, Lima ZP, Kushima H, Monteiro Souza Brito AR, Campaner dos Santos L, Vilegas W, Hiruma-Lima CA. Polyphenols with Antiulcerogenic Action from Aqueous Decoction of Mango Leaves (Mangifera indica L.). Molecules. 2009; 14(3):1098-1110.
Severi, Juliana Aparecida; Lima, Zeila Pinheiro; Kushima, Hélio; Monteiro Souza Brito, Alba Regina; Campaner dos Santos, Lourdes; Vilegas, Wagner; Hiruma-Lima, Clélia Akiko. 2009. "Polyphenols with Antiulcerogenic Action from Aqueous Decoction of Mango Leaves (Mangifera indica L.)." Molecules 14, no. 3: 1098-1110.