Molecules 2009, 14(3), 1098-1110; doi:10.3390/molecules14031098
Article

Polyphenols with Antiulcerogenic Action from Aqueous Decoction of Mango Leaves (Mangifera indica L.)

Received: 1 January 2009; in revised form: 12 January 2009 / Accepted: 22 January 2009 / Published: 10 March 2009
(This article belongs to the Special Issue Phenolics and Polyphenolics)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: This study was designed to determine the gastroprotective effect of a Mangifera indica leaf decoction (AD), on different experimental models in rodents. The administration of AD up to a dose of 5 g/kg (p.o.) did not produce any signs or symptoms of toxicity in the treated animals, while significantly decreasing the severity of gastric damage induced by several gastroprotective models. Oral pre-treatment with AD (250, 500 or 1000 mg/kg) in mice and rats with gastric lesions induced by HCl/ethanol, absolute ethanol, non-steroidal anti-inflammatory drug (NSAID) or stress-induced gastric lesions resulted in a significant decrease of said lesions. Phytochemical analyses of AD composition demonstrated the presence of bioactive phenolic compounds that represent 57.3% of total phenolic content in this extract. Two main phenolic compounds were isolated, specifically mangiferin (C-glucopyranoside of 1,3,6,7-tetrahydroxyxanthone) and C-glucosyl-benzophenone (3-C-β-D-glucopyranosyl-4’,2,4,6-tetrahydroxybenzophenone). These findings indicate the potential gastroprotective properties of aqueous decoction from M. indica leaves.
Keywords: Mangifera indica; Antiulcer gastric; Mangiferin; Benzophenone; Phenolic compounds
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MDPI and ACS Style

Severi, J.A.; Lima, Z.P.; Kushima, H.; Monteiro Souza Brito, A.R.; Campaner dos Santos, L.; Vilegas, W.; Hiruma-Lima, C.A. Polyphenols with Antiulcerogenic Action from Aqueous Decoction of Mango Leaves (Mangifera indica L.). Molecules 2009, 14, 1098-1110.

AMA Style

Severi JA, Lima ZP, Kushima H, Monteiro Souza Brito AR, Campaner dos Santos L, Vilegas W, Hiruma-Lima CA. Polyphenols with Antiulcerogenic Action from Aqueous Decoction of Mango Leaves (Mangifera indica L.). Molecules. 2009; 14(3):1098-1110.

Chicago/Turabian Style

Severi, Juliana Aparecida; Lima, Zeila Pinheiro; Kushima, Hélio; Monteiro Souza Brito, Alba Regina; Campaner dos Santos, Lourdes; Vilegas, Wagner; Hiruma-Lima, Clélia Akiko. 2009. "Polyphenols with Antiulcerogenic Action from Aqueous Decoction of Mango Leaves (Mangifera indica L.)." Molecules 14, no. 3: 1098-1110.

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