Next Article in Journal
Laser Photolysis and Thermolysis of Organic Selenides and Tellurides for Chemical Gas-phase Deposition of Nanostructured Materials
Next Article in Special Issue
Molecular Docking Studies and Anti-enzymatic Activities of Thai Mango Seed Kernel Extract Against Snake Venoms
Previous Article in Journal
Structural Changes of Malt Proteins During Boiling
Previous Article in Special Issue
Anti-hemorrhagic Activity of Four Brazilian Vegetable Species Against Bothrops jararaca Venom
Article Menu

Export Article

Open AccessArticle
Molecules 2009, 14(3), 1098-1110; doi:10.3390/molecules14031098

Polyphenols with Antiulcerogenic Action from Aqueous Decoction of Mango Leaves (Mangifera indica L.)

1
-Pharmacos and Drugs Department, Pharmaceutical Sciences Faculty, São Paulo State University-UNESP, c.p.355, Zip Code: 14801-902, UNESP, Araraquara, SP, Brazil
2
Physiology Department, Biosciences Institute, São Paulo State University-UNESP, c.p. 510, Zip Code: 18618-000, Botucatu, SP, Brazil
3
Physiology and Biophysics Department, Biology Institute, Campinas State University-UNICAMP, c.p. 6109, Zip Code: 13083-970, Campinas, SP, Brazil
4
Organic Chemistry Department, Chemistry Institute, São Paulo State University-UNESP, c.p. 355, Zip Code: 14800-900, UNESP, Araraquara, SP, Brazil
*
Author to whom correspondence should be addressed.
Received: 1 January 2009 / Revised: 12 January 2009 / Accepted: 22 January 2009 / Published: 10 March 2009
(This article belongs to the Special Issue Phenolics and Polyphenolics)
View Full-Text   |   Download PDF [197 KB, uploaded 18 June 2014]   |  

Abstract

This study was designed to determine the gastroprotective effect of a Mangifera indica leaf decoction (AD), on different experimental models in rodents. The administration of AD up to a dose of 5 g/kg (p.o.) did not produce any signs or symptoms of toxicity in the treated animals, while significantly decreasing the severity of gastric damage induced by several gastroprotective models. Oral pre-treatment with AD (250, 500 or 1000 mg/kg) in mice and rats with gastric lesions induced by HCl/ethanol, absolute ethanol, non-steroidal anti-inflammatory drug (NSAID) or stress-induced gastric lesions resulted in a significant decrease of said lesions. Phytochemical analyses of AD composition demonstrated the presence of bioactive phenolic compounds that represent 57.3% of total phenolic content in this extract. Two main phenolic compounds were isolated, specifically mangiferin (C-glucopyranoside of 1,3,6,7-tetrahydroxyxanthone) and C-glucosyl-benzophenone (3-C-β-D-glucopyranosyl-4’,2,4,6-tetrahydroxybenzophenone). These findings indicate the potential gastroprotective properties of aqueous decoction from M. indica leaves. View Full-Text
Keywords: Mangifera indica; Antiulcer gastric; Mangiferin; Benzophenone; Phenolic compounds Mangifera indica; Antiulcer gastric; Mangiferin; Benzophenone; Phenolic compounds
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Severi, J.A.; Lima, Z.P.; Kushima, H.; Monteiro Souza Brito, A.R.; Campaner dos Santos, L.; Vilegas, W.; Hiruma-Lima, C.A. Polyphenols with Antiulcerogenic Action from Aqueous Decoction of Mango Leaves (Mangifera indica L.). Molecules 2009, 14, 1098-1110.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top