Molecules 2009, 14(10), 4065-4078; doi:10.3390/molecules14104065
Article

Sulphated Zirconia as an Eco-Friendly Catalyst in Acylal Preparation under Solvent-Free Conditions, Acylal Deprotection Assisted by Microwaves, and the Synthesis of Anhydro-Dimers of o-Hydroxybenzaldehydes

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Received: 25 August 2009; in revised form: 21 September 2009 / Accepted: 27 September 2009 / Published: 12 October 2009
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: A solvent-free approach is described for the regioselective synthesis of acylals (1,1-diacetates) in shorter reaction times and higher yields, compared to conventional methodology using solvents. In the protection reaction of the o-hydroxybenzaldehyde the formation of acetyl compounds and anhydro-dimers was observed. The deprotection reaction involves microwave (MW) exposure of diluted reactants in the presence of solid sulphated zirconia (SZ) catalyst that can be easily recovered and reused. The sulphated zirconia was recycled several times without any loss of activity.
Keywords: sulphated zirconia; solvent-free; microwaves; regioselective; diacetates
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MDPI and ACS Style

Palacios-Grijalva, L.N.; Cruz-González, D.Y.; Lomas-Romero, L.; González-Zamora, E.; Ulibarri, G.; Negrón-Silva, G.E. Sulphated Zirconia as an Eco-Friendly Catalyst in Acylal Preparation under Solvent-Free Conditions, Acylal Deprotection Assisted by Microwaves, and the Synthesis of Anhydro-Dimers of o-Hydroxybenzaldehydes. Molecules 2009, 14, 4065-4078.

AMA Style

Palacios-Grijalva LN, Cruz-González DY, Lomas-Romero L, González-Zamora E, Ulibarri G, Negrón-Silva GE. Sulphated Zirconia as an Eco-Friendly Catalyst in Acylal Preparation under Solvent-Free Conditions, Acylal Deprotection Assisted by Microwaves, and the Synthesis of Anhydro-Dimers of o-Hydroxybenzaldehydes. Molecules. 2009; 14(10):4065-4078.

Chicago/Turabian Style

Palacios-Grijalva, Laura N.; Cruz-González, Deysi Y.; Lomas-Romero, Leticia; González-Zamora, Eduardo; Ulibarri, Gerardo; Negrón-Silva, Guillermo E. 2009. "Sulphated Zirconia as an Eco-Friendly Catalyst in Acylal Preparation under Solvent-Free Conditions, Acylal Deprotection Assisted by Microwaves, and the Synthesis of Anhydro-Dimers of o-Hydroxybenzaldehydes." Molecules 14, no. 10: 4065-4078.

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