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Molecules 2009, 14(10), 4065-4078; doi:10.3390/molecules14104065

Sulphated Zirconia as an Eco-Friendly Catalyst in Acylal Preparation under Solvent-Free Conditions, Acylal Deprotection Assisted by Microwaves, and the Synthesis of Anhydro-Dimers of o-Hydroxybenzaldehydes

1
Departamento de Ciencias Básicas, UAM-A, Av. San Pablo, No. 180. C.P. 02200, México, D.F., Mexico
2
Departamento de Química, UAM-I, San Rafael Atlixco, No. 186. C.P. 09340, México, D.F., Mexico
3
Department of Chemistry & Biochemistry, Laurentian University, Sudbury, ON P3E2C6, Canada
*
Author to whom correspondence should be addressed.
Received: 25 August 2009 / Revised: 21 September 2009 / Accepted: 27 September 2009 / Published: 12 October 2009
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Abstract

A solvent-free approach is described for the regioselective synthesis of acylals (1,1-diacetates) in shorter reaction times and higher yields, compared to conventional methodology using solvents. In the protection reaction of the o-hydroxybenzaldehyde the formation of acetyl compounds and anhydro-dimers was observed. The deprotection reaction involves microwave (MW) exposure of diluted reactants in the presence of solid sulphated zirconia (SZ) catalyst that can be easily recovered and reused. The sulphated zirconia was recycled several times without any loss of activity.
Keywords: sulphated zirconia; solvent-free; microwaves; regioselective; diacetates sulphated zirconia; solvent-free; microwaves; regioselective; diacetates
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Palacios-Grijalva, L.N.; Cruz-González, D.Y.; Lomas-Romero, L.; González-Zamora, E.; Ulibarri, G.; Negrón-Silva, G.E. Sulphated Zirconia as an Eco-Friendly Catalyst in Acylal Preparation under Solvent-Free Conditions, Acylal Deprotection Assisted by Microwaves, and the Synthesis of Anhydro-Dimers of o-Hydroxybenzaldehydes. Molecules 2009, 14, 4065-4078.

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