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Molecules 2009, 14(10), 4051-4064; doi:10.3390/molecules14104051
Article

Synthesis of Lipoamino Acids and Their Activity against Cerebral Ischemic Injury

, , , ,  and *
Institute of Pharmaceutical Research, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
* Author to whom correspondence should be addressed.
Received: 14 August 2009 / Revised: 22 September 2009 / Accepted: 29 September 2009 / Published: 12 October 2009
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Abstract

A series of lipoamino acids were synthesized and their neuroprotective effect against brain ischemia induced by oxygen-glucose deprivation (OGD) on rat cerebral slices was evaluated. Among these compounds, N-stearoyl-L-tyrosine (4), N-stearoyl-L-serine (5) and N-stearoyl-L-threonine (6) exhibited good neuroprotective activity. We found that the neuroprotective activity of lipoamino acids depended on the acyl group, the presence of a free carboxylic function and a free hydroxyl group at the branched chain of the amino acids. The results also showed that 5 was the most active compound, protecting rat brain slices against OGD as well as hydrogen peroxide (H2O2) insult at the range of 1–10 M.
Keywords: lipoamino acids; neuroprotection; brain ischemia; oxygen-glucose deprivation lipoamino acids; neuroprotection; brain ischemia; oxygen-glucose deprivation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Yao, L.-Y.; Lin, Q.; Niu, Y.-Y.; Deng, K.-M.; Zhang, J.-H.; Lu, Y. Synthesis of Lipoamino Acids and Their Activity against Cerebral Ischemic Injury. Molecules 2009, 14, 4051-4064.

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