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Molecules 2009, 14(10), 4051-4064; doi:10.3390/molecules14104051

Synthesis of Lipoamino Acids and Their Activity against Cerebral Ischemic Injury

, , , ,  and *
Institute of Pharmaceutical Research, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
* Author to whom correspondence should be addressed.
Received: 14 August 2009 / Revised: 22 September 2009 / Accepted: 29 September 2009 / Published: 12 October 2009
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A series of lipoamino acids were synthesized and their neuroprotective effect against brain ischemia induced by oxygen-glucose deprivation (OGD) on rat cerebral slices was evaluated. Among these compounds, N-stearoyl-L-tyrosine (4), N-stearoyl-L-serine (5) and N-stearoyl-L-threonine (6) exhibited good neuroprotective activity. We found that the neuroprotective activity of lipoamino acids depended on the acyl group, the presence of a free carboxylic function and a free hydroxyl group at the branched chain of the amino acids. The results also showed that 5 was the most active compound, protecting rat brain slices against OGD as well as hydrogen peroxide (H2O2) insult at the range of 1–10 M.
Keywords: lipoamino acids; neuroprotection; brain ischemia; oxygen-glucose deprivation lipoamino acids; neuroprotection; brain ischemia; oxygen-glucose deprivation
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Yao, L.-Y.; Lin, Q.; Niu, Y.-Y.; Deng, K.-M.; Zhang, J.-H.; Lu, Y. Synthesis of Lipoamino Acids and Their Activity against Cerebral Ischemic Injury. Molecules 2009, 14, 4051-4064.

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