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Total Synthesis and the Biological Activities of (±)-Norannuradhapurine
AbstractThe structure previously assigned to the phenolic noraporphine alkaloid, (-)-norannuradhapurine has been confirmed by a total synthesis of the racemic alkaloid in which the key step involved the formation of the C ring by a radical-initiated cyclization. although inactive against Staphylococcus aureus ATCC25932, Escherichia coli ATCC10536 and Candida albicans ATCC90028, (±)-norannuradhapurine inhibits the production of NO, PGE2, TNF-a, IL-1b and IL-6 and the expression of iNOS and COX-2 in RAW 264.7 macrophages stimulated with LPS in vitro.
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Nimgirawath, S.; Lorpitthaya, R.; Wanbanjob, A.; Taechowisan, T.; Shen, Y.-M. Total Synthesis and the Biological Activities of (±)-Norannuradhapurine. Molecules 2009, 14, 89-101.View more citation formats
Nimgirawath S, Lorpitthaya R, Wanbanjob A, Taechowisan T, Shen Y-M. Total Synthesis and the Biological Activities of (±)-Norannuradhapurine. Molecules. 2009; 14(1):89-101.Chicago/Turabian Style
Nimgirawath, Surachai; Lorpitthaya, Rujee; Wanbanjob, Asawin; Taechowisan, Thongchai; Shen, Yue-Mao. 2009. "Total Synthesis and the Biological Activities of (±)-Norannuradhapurine." Molecules 14, no. 1: 89-101.
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