Next Article in Journal
The Inhibitory Action of Kohamaic Acid A Derivatives on Mammalian DNA Polymerase β
Next Article in Special Issue
Total Syntheses of Telisatin A, Telisatin B and Lettowianthine
Previous Article in Journal
Synthesis of 5-Substituted 3-Amino-1H-Pyrazole-4-Carbonitriles as Precursors for Microwave Assisted Regiospecific Syntheses of Pyrazolo[1,5-a]Pyrimidines
Previous Article in Special Issue
Total Synthesis and Antimicrobial Activity of (±)-Laurelliptinhexadecan-1-one and (±)-Laurelliptinoctadecan-1-one
Molecules 2009, 14(1), 89-101; doi:10.3390/molecules14010089
Article

Total Synthesis and the Biological Activities of (±)-Norannuradhapurine

1,* , 1
, 1
, 2
 and 3
Received: 2 December 2008; in revised form: 19 December 2008 / Accepted: 23 December 2008 / Published: 29 December 2008
(This article belongs to the Special Issue Aporphines and Oxoaporphines)
Download PDF [114 KB, uploaded 18 June 2014]
Abstract: The structure previously assigned to the phenolic noraporphine alkaloid, (-)-norannuradhapurine has been confirmed by a total synthesis of the racemic alkaloid in which the key step involved the formation of the C ring by a radical-initiated cyclization. although inactive against Staphylococcus aureus ATCC25932, Escherichia coli ATCC10536 and Candida albicans ATCC90028, (±)-norannuradhapurine inhibits the production of NO, PGE2, TNF-a, IL-1b and IL-6 and the expression of iNOS and COX-2 in RAW 264.7 macrophages stimulated with LPS in vitro.
Keywords: Alkaloid; Anti-inflammatory Activity; Aporphine; Isoquinoline; Synthesis; Radical Cyclization Alkaloid; Anti-inflammatory Activity; Aporphine; Isoquinoline; Synthesis; Radical Cyclization
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Nimgirawath, S.; Lorpitthaya, R.; Wanbanjob, A.; Taechowisan, T.; Shen, Y.-M. Total Synthesis and the Biological Activities of (±)-Norannuradhapurine. Molecules 2009, 14, 89-101.

AMA Style

Nimgirawath S, Lorpitthaya R, Wanbanjob A, Taechowisan T, Shen Y-M. Total Synthesis and the Biological Activities of (±)-Norannuradhapurine. Molecules. 2009; 14(1):89-101.

Chicago/Turabian Style

Nimgirawath, Surachai; Lorpitthaya, Rujee; Wanbanjob, Asawin; Taechowisan, Thongchai; Shen, Yue-Mao. 2009. "Total Synthesis and the Biological Activities of (±)-Norannuradhapurine." Molecules 14, no. 1: 89-101.


Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert