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Molecules 2009, 14(3), 917-924; doi:10.3390/molecules14030917
Article

Total Syntheses of Telisatin A, Telisatin B and Lettowianthine

*  and
Department of Chemistry, Faculty of Science, Silpakorn University; Nakorn Pathom 73000, Thailand
* Author to whom correspondence should be addressed.
Received: 2 February 2009 / Revised: 17 February 2009 / Accepted: 26 February 2009 / Published: 26 February 2009
(This article belongs to the Special Issue Aporphines and Oxoaporphines)
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Abstract

Treatment of 1-(2-bromoarylmethyl)-3,4-dihydroisoquinolines with oxalyl chloride and triethylamine gave 1-(2-bromophenyl)-5,6-dihydropyrrolo[2,1-a]isoquinoline-2,3-dione derivatives, for example, 1-(2-bromophenyl)-5,6-dihydro-8,9-dimethoxypyrrolo[2,1-a]isoquinoline-2,3-dione. Radical cyclisation of these derivatives with tributyltin hydride and 1,1-azobis(cyclohexanecarbonitrile) afforded telisatin A, telisatin B and lettowianthine.
Keywords: Alkaloid; Dioxoaporphine; Isoquinoline; Radical cyclisation; Synthesis Alkaloid; Dioxoaporphine; Isoquinoline; Radical cyclisation; Synthesis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Nimgirawath, S.; Udomputtimekakul, P. Total Syntheses of Telisatin A, Telisatin B and Lettowianthine. Molecules 2009, 14, 917-924.

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